Results 101 to 110 of about 113,461 (351)
Arthritis &Rheumatology, Accepted Article.Objective The transition from asymptomatic anti‐nuclear antibody (ANA) positivity to systemic autoimmune rheumatic disease (SARD) is associated with increased production of pro‐inflamamtory factors such as TNF‐α. Here we investigate whether the relative absence of inflammation in asymptomatic ANA+ individuals (ANA+NS) results from a lack of circulating
Carolina Muñoz‐Grajales +8 more
wiley +1 more source
Sialic acids and the metabolism of low density lipoprotein.
Journal of Lipid Research, 1996 Sialic acid-poor low density lipoprotein (LDL) is suggested to be atherogenic because it causes in vitro accumulation of cholesterol into epithelial cells and macrophages. We studied whether the whole-body catabolism of LDL varies according to its sialic
N Melajärvi, H Gylling, T A Miettinen
doaj +1 more source
Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. [PDF]
, 2018 Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface.
Haigh, Nathan E +9 more
core
Prediction of specific virus outbreaks made from the increased concentration of a new class of virus genomic peptides, replikins. [PDF]
, 2011 Advance warning of pathogen outbreaks has not been possible heretofore. A new class of genomic peptides associated with rapid replication was discovered and named replikins. Software was designed to analyze replikins quantitatively.
Elenore S. Bogoch, Samuel Bogoch
core +2 more sources
Absolute bioavailability and intravenous pharmacokinetics of N‐acetyl‐D‐mannosamine in humans
British Journal of Clinical Pharmacology, EarlyView.Aims N‐acetyl‐D‐mannosamine monohydrate (ManNAc) is a naturally occurring monosaccharide that has attracted considerable attention for its potential in treating GNE myopathy, a rare autosomal recessive muscle disorder. Despite its promise as an oral treatment, the absolute bioavailability of oral ManNAc has not been determined and there has been no ...
Tahlia R. Meola +6 more
wiley +1 more source
Glycan analysis of the chicken synaptic plasma membrane glycoproteins - a major synaptic N-glycan carries the LewisX determinant [PDF]
, 2005 The majority of plasma membrane components are glycosylated. It is now widely accepted that this post-translational modification is crucial during the establishment, maintenance and function of the nervous system.
Koles, Kate +3 more
core +4 more sources
Exploration of the Sialic Acid World
, 2018 Sialic acids are cytoprotectors, mainly localized on the surface of cell membranes with multiple and outstanding cell biological functions. The history of their structural analysis, occurrence, and functions is fascinating and described in this review.
Roland Schauer, Johannis P. Kamerling
openaire +2 more sources
Dynamic pH profiles drive higher cell‐specific and volumetric productivity
Biotechnology Progress, EarlyView.Implementation of dyamic pH profiles for increased CHO cell culture productivity. Abstract Mammalian cell cultures in bioreactors rely heavily on critical process parameter control to ensure optimal growth, productivity, and reproducibility to produce recombinant therapeutic proteins. Culture pH has been shown to be a critical parameter that influences
Stephanie R. Klaubert +6 more
wiley +1 more source
An overview about erythrocyte membrane [PDF]
, 2010 © 2010 – IOS Press and the authors. All rights reservedIn the sixties and seventies, erythrocytes or red blood cells (RBCs) were extensively studied. Much has been learnt particularly concerning their metabolism and gas transporter function. In the past
Oliveira, Sofia de, Saldanha, Carlota
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Harnessing chimeric antigen receptor macrophages against solid tumors
Cancer Communications, EarlyView.Abstract Macrophages are prevalent in multiple tumors and exhibit diverse and potent functional activities. Therapeutic reprogramming of macrophage phenotypes represents a promising strategy for cancer immunotherapy. Engineering chimeric antigen receptors (CARs) to endow macrophages with anti‐tumor capacities demonstrated encouraging efficacy ...
Mengru Wang +3 more
wiley +1 more source