Results 101 to 110 of about 116,138 (312)

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, EarlyView.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Atomic Resolution Structure of the Oncolytic Parvovirus LuIII by Electron Microscopy and 3D Image Reconstruction. [PDF]

, 2017
LuIII, a protoparvovirus pathogenic to rodents, replicates in human mitotic cells, making it applicable for use to kill cancer cells. This virus group includes H-1 parvovirus (H-1PV) and minute virus of mice (MVM).
Agbandje-McKenna, Mavis, Baker, Timothy S, Chipman, Paul, Cotmore, Susan, D'Abramo, Anthony, Geilen, Lorena, Halder, Sujata, Janssen, Mandy, Kurian, Justin, Mckenna, Robert, Misseldine, Adam, Pittman, Nikéa, Smith, J Kennon, Tattersall, Peter   +13 more
core   +3 more sources

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, EarlyView.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source

Membrane glycomics reveal heterogeneity and quantitative distribution of cell surface sialylation. [PDF]

, 2018
Given that unnatural sugar expression is metabolically achieved, the kinetics and disposition of incorporation can lend insight into the temporal and localization preferences of sialylation across the cell surface.
Haigh, Nathan E, Lebrilla, Carlito B, Liu, Mingqi, Maverakis, Emanual, Park, Diane Dayoung, Phoomak, Chatchai, Wong, Maurice, Wongkham, Sopit, Xu, Gege, Yang, Pengyuan   +9 more
core  

Clinical Applica­tion of Sialic Acid I. On Serum Sialic Acid Contents in Patients [PDF]

, 1957
1) The contents of sialic acid in patients of various diseases sera were determined and increases of it were noticed in several diseases. 2) Sialic acid contents ranged between 50 and 100 mg./dl. in the normal serum.
Mori, Akitane, Onoda, Osamu, Suga, Masaaki, Yui, Yutaka   +3 more
core   +1 more source

Machine Learning‐Enhanced Analysis of Exosomal Surface Sialic Acid Using Surface‐Enhanced Raman Spectroscopy for Ovarian Cancer Diagnosis and Therapeutic Monitoring

Advanced Science, EarlyView.
Machine learning‐assisted surface‐enhanced Raman spectroscopy analysis of exosomal sialic acid for ovarian cancer diagnosis, as well as independent monitoring of exosomal sialic acid expression levels across different treatment periods, reveals a potential correlation with treatment response.
Lili Cong, Jiaqi Wang, Sijun Huang, Xiaxia Man, Yi Guo, Shuping Xu, Songling Zhang   +6 more
wiley   +1 more source

Substrate-bound outward-open structure of a Na+-coupled sialic acid symporter reveals a new Na+ site

Nature Communications, 2018
Sialic acid transporters (SiaT) are required for sialic acid uptake in a number of human pathogens and are of interest as targets for antimicrobial drug development. Here the authors present the substrate bound SiaT structure from the uropathogen Proteus
Weixiao Y. Wahlgren, Elin Dunevall, Rachel A. North, Aviv Paz, Mariafrancesca Scalise, Paola Bisignano, Johan Bengtsson-Palme, Parveen Goyal, Elin Claesson, Rhawnie Caing-Carlsson, Rebecka Andersson, Konstantinos Beis, Ulf J. Nilsson, Anne Farewell, Lorena Pochini, Cesare Indiveri, Michael Grabe, Renwick C. J. Dobson, Jeff Abramson, S. Ramaswamy, Rosmarie Friemann   +20 more
doaj   +1 more source

Sialic acids and the metabolism of low density lipoprotein.

Journal of Lipid Research, 1996
Sialic acid-poor low density lipoprotein (LDL) is suggested to be atherogenic because it causes in vitro accumulation of cholesterol into epithelial cells and macrophages. We studied whether the whole-body catabolism of LDL varies according to its sialic
N Melajärvi, H Gylling, T A Miettinen
doaj   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Biomimetic Membrane Interface Technologies for Detection and Isolation of CTCs and EVs: Advances and Opportunities in Liquid Biopsy

Advanced Science, EarlyView.
Biomimetic membrane interface engineering constructs functionalized detection platforms by integrating natural cell membranes, synthetic lipids, or hybrid membranes. This strategy effectively reduces background interference and enables efficient target capture and analysis, showing broad applications in circulating tumor cell separation, extracellular ...
Duo Liu, Jie Yu, Jingxue Li, Yixue Chen, Mengle Peng, Yifan Xu, Yongjun Wu, Lihua Ding, Sitian He   +8 more
wiley   +1 more source