Results 121 to 130 of about 70,942 (317)

Combinatorial Design of a Sialic Acid-Imprinted Binding Site [PDF]

open access: gold, 2021
Liliia Mavliutova   +3 more
openalex   +1 more source

Differences in IgG Sialylation Distinguish Asymptomatic From Symptomatic Antinuclear Antibody–Positive Individuals

open access: yesArthritis &Rheumatology, EarlyView.
Objective The transition from asymptomatic antinuclear antibody (ANA) positivity to systemic autoimmune rheumatic disease (SARD) is associated with increased production of proinflammatory factors such as tumor necrosis factor α (TNFα). Here we investigate whether the relative absence of inflammation in asymptomatic ANA+ individuals (ANA+NS) results ...
Carolina Muñoz‐Grajales   +8 more
wiley   +1 more source

Cloning of hemagglutinin (HA) protein of influenza A virus - Potential for sialic acid linkage discrimination [PDF]

open access: yes, 2007
The initial step in infection of a cell by influenza A virus is the attachment of a virus particle to the target cell. This is accomplished by interaction of a glycoprotein, hemagglutinin (HA), found on the surface of the viral lipid membrane with cell ...
O'Connor, Brendan, Szczepaniak, Jakub
core  

Absolute bioavailability and intravenous pharmacokinetics of N‐acetyl‐D‐mannosamine in humans

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims N‐acetyl‐D‐mannosamine monohydrate (ManNAc) is a naturally occurring monosaccharide that has attracted considerable attention for its potential in treating GNE myopathy, a rare autosomal recessive muscle disorder. Despite its promise as an oral treatment, the absolute bioavailability of oral ManNAc has not been determined and there has been no ...
Tahlia R. Meola   +6 more
wiley   +1 more source

Dynamic pH profiles drive higher cell‐specific and volumetric productivity

open access: yesBiotechnology Progress, EarlyView.
Implementation of dyamic pH profiles for increased CHO cell culture productivity. Abstract Mammalian cell cultures in bioreactors rely heavily on critical process parameter control to ensure optimal growth, productivity, and reproducibility to produce recombinant therapeutic proteins. Culture pH has been shown to be a critical parameter that influences
Stephanie R. Klaubert   +6 more
wiley   +1 more source

Expanding the Toolbox for Inducible Protein Expression With Automation‐enabled Generation of Glycomimetics

open access: yesChemistry – A European Journal, EarlyView.
Inducible protein expression is a cornerstone of many aspects of industrial and molecular biotechnological processes. 2′‐fucosyl isopropyl‐β‐D‐thiogalactopyranose (2′F‐IPTG) and 2′‐fucosyl isobutyl‐C‐galactoside (2′F‐IBCG) mimics were explored for protein expression studies.
Ashley E. DeYong   +6 more
wiley   +1 more source

A novel family of bacterial sialic acid binding adhesins? [PDF]

open access: yes, 2020
of Distinction at Nationwide Children's Annual Research RetreatThird place in Biomedical Sciences at the Denman Undergraduate Research ForumPlatelet binding is a critical step in the development of Infective Endocarditis (IE), an infection of the ...
Patel, Surina
core  

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