Results 171 to 180 of about 863,961 (270)

Protein O‐Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations

The FASEB Journal, Volume 40, Issue 18, 30 September 2026.
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Jasmin Frey, Annkathrin Ratter, Finn Brigger, Louie Cielen, Pascal Kunz, Ea Tulin, Kinga Mikos, Lothar Dieterich, Marco D'Addio, Cornelia Halin, Richard D. Cummings, Vivianne I. Otto   +11 more
wiley   +1 more source

Sialic acids modulate immune responses in cancer: Therapeutic opportunities. [PDF]

J Biol Chem
Bashian EE, Paulson JC, Wu P.
europepmc   +1 more source

Sialic Acids on Tumor Cells Modulate IgA Therapy by Neutrophils via Inhibitory Receptors Siglec-7 and Siglec-9. [PDF]

Cancers (Basel), 2023
Chan C, Lustig M, Jansen JHM, Garcia Villagrasa L, Raymakers L, Daamen LA, Valerius T, van Tetering G, Leusen JHW.   +8 more
europepmc   +1 more source

Cataloging natural sialic acids and other nonulosonic acids (NulOs), and their representation using the Symbol Nomenclature for Glycans. [PDF]

Glycobiology, 2023
Lewis AL, Toukach P, Bolton E, Chen X, Frank M, Lütteke T, Knirel Y, Schoenhofen I, Varki A, Vinogradov E, Woods RJ, Zachara N, Zhang J, Kamerling JP, Neelamegham S, SNFG Discussion Group.   +15 more
europepmc   +1 more source

Sialic acids in cancer biology and immunity-recent advancements. [PDF]

J Biol Chem
van Vliet SJ, van Kooyk Y.
europepmc   +1 more source

Sialic acids Neu5Ac and KDN in adipose tissue samples from individuals following habitual vegetarian or non-vegetarian dietary patterns. [PDF]

Sci Rep, 2023
Guerrero-Flores GN, Pacheco FJ, Boskovic DS, Pacheco SOS, Zhang G, Fraser GE, Miles FL.   +6 more
europepmc   +1 more source

Using Synthetic Glycans to Investigate Anti‐Glycan Antibodies and Explore Their Medical Potential

Angewandte Chemie International Edition, Volume 65, Issue 39, 21 September 2026.
Anti‐glycan antibodies are essential in health and disease. Access to novel glycan structures paves the way for progress in antibody profiling for biomarker discovery, antibody development, and vaccine design. We summarize the strategies to synthesize and utilize synthetic glycans for the development and application of anti‐glycan antibodies in basic ...
Fabienne Weber, Aina Valenti, Jiří Ledvinka, Oren Moscovitz, Peter H. Seeberger   +4 more
wiley   +1 more source

Cellular homeostasis of N-acetylneuraminic acid and non-canonical sialic acids is mediated by human N-acetylneuraminate lyase. [PDF]

Glycobiology
Huang S, Harmsen I, Rahm M, Kentache T, van Karnebeek CDM, Da Silva A, Pshezhetsky AV, Van Schaftingen E, Garanto A, Lefeber DJ.   +9 more
europepmc   +1 more source

SARS-CoV-2 Spike N-Terminal Domain Engages 9-O-Acetylated α2-8-Linked Sialic Acids. [PDF]

ACS Chem Biol, 2023
Tomris I, Unione L, Nguyen L, Zaree P, Bouwman KM, Liu L, Li Z, Fok JA, Ríos Carrasco M, van der Woude R, Kimpel ALM, Linthorst MW, Kilavuzoglu SE, Verpalen ECJM, Caniels TG, Sanders RW, Heesters BA, Pieters RJ, Jiménez-Barbero J, Klassen JS, Boons GJ, de Vries RP.   +21 more
europepmc   +1 more source

Determination of Sialic Acids by Acidic Ninhydrin Reaction

A new acidic ninhydrin method for determining free sialic acids is described. The method is based on the reaction of sialic acids with Gaitonde's acid ninhydrin reagent 2 which yields a stable color with an absorption maximum at 470 nm.
Yao, Kenzabroh, Ubuka, Toshihiko
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