Results 71 to 80 of about 19,716 (237)

The genetics of cardiovascular disease [PDF]

, 2008
Recent advances in genotyping technology and insights into disease mechanisms have increased interest in the genetics of cardiovascular disease. Several candidate genes involved in cardiovascular diseases were identified from studies using animal models,
Abu-Amero, Aitman, Anna F. Dominiczak, Benhamou, Bhatnagar, Bowcock, Caulfield, Chen, Christian Delles, Clark, Conrad, Cowley, Cupples, Delles, Delles, Delles, Dominiczak, Dominiczak, Dutil, Edwards, Emilsson, Garrett, Good, Graham, Grunfeld, Gunderson, Guzik, Hamilton, Hamilton, Harrap, Hunt, Iwai, Jakubowska, Jeffs, Jeffs, Ji, Kathiresan, Kerr, Klein, Latronico, Levy, Martin W. McBride, Matarín, Matarín, Matsuzaki, McBride, McBride, McCarthy, Monti, Moreno, Mueller, Newhouse, Oniki, Padmanabhan, Padmanabhan, Petretto, Pollex, Rapp, Roodi, Samani, Sandhu, Sandosh Padmanabhan, Sayed-Tabatabaei, Sharma, Staessen, Teo, Tobin, Tobin, Turner, Wallace, Wilson, Zalba, Zimmerli   +72 more
core   +1 more source

Loss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1.

PLoS ONE, 2015
The central molecular event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrPC), which is a sialoglycoprotein, into the disease-associated, transmissible form denoted PrPSc.
Elizaveta Katorcha, Nina Klimova, Natallia Makarava, Regina Savtchenko, Xuefang Pan, Ida Annunziata, Kohta Takahashi, Taeko Miyagi, Alexey V Pshezhetsky, Alessandra d'Azzo, Ilia V Baskakov   +10 more
doaj   +1 more source

Dramatic expansion of the black widow toxin arsenal uncovered by multi-tissue transcriptomics and venom proteomics. [PDF]

, 2014
BackgroundAnimal venoms attract enormous interest given their potential for pharmacological discovery and understanding the evolution of natural chemistries.
Ayoub, Nadia A, Clarke, Thomas H, Garb, Jessica E, Haney, Robert A, Hayashi, Cheryl Y   +4 more
core   +2 more sources

Siglec‐7 and Siglec‐9 expression in primary triple negative and oestrogen receptor positive breast cancer and in vitro signalling

Clinical &Translational Immunology, Volume 13, Issue 9, September 2024.
In this study, we found high Siglec‐7 and Siglec‐9 (ligand) expression in triple negative breast cancer, and to a lower extent in oestrogen receptor positive breast cancer. Moreover, signalling experiments demonstrated that Siglec‐7 signalling is induced by triple negative breast cancer cell lines.
Eline JH van Houtum, Anne HC Valk, Daniel Granado, Jasper Lok, Lune van den Bogaard, Naomi Remkes, Jesper van Eck van der Sluijs, Paul N Span, Lenneke AM Cornelissen, Gosse J Adema   +9 more
wiley   +1 more source

CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics, ionic microenvironments, ion fluxes, neuronal activation, and network neurotransductive capacity

Journal of Neuroscience Research, Volume 102, Issue 7, July 2024.
Proteoglycans are important multifunctional components of the central and peripheral nervous systems and represent a diverse group of specialized proteins that stabilize and functionalize these tissues. Abstract Central and peripheral nervous system (CNS/PNS) proteoglycans (PGs) have diverse functional roles, this study examined how these control ...
James Melrose
wiley   +1 more source

CD133 and CD24 expression in renal tissue of patients affected by autosomal dominant polcystic kidney disease [PDF]

, 2013
Background: Autosomal dominant polycystic kidney disease is a condition mainly character- ized by the progressive development and enlar- gement of cysts in each kidney.
CAPPELLI, Gianni, CAVAZZINI, FABRIZIO, LIGABUE, Giulia, LODI, DANIELE, LUPO, Valentina, MAGISTRONI, Riccardo   +5 more
core   +1 more source

OMIP‐102: 50‐color phenotyping of the human immune system with in‐depth assessment of T cells and dendritic cells

Cytometry Part A, Volume 105, Issue 6, Page 430-436, June 2024.
Abstract We report the development of an optimized 50‐color spectral flow cytometry panel designed for the in‐depth analysis of the immune system in human blood and tissues, with the goal of maximizing the amount of information that can be collected using currently available flow cytometry platforms.
Andrew J. Konecny, Peter L. Mage, Aaron J. Tyznik, Martin Prlic, Florian Mair   +4 more
wiley   +1 more source

Synthesis of sialoglycopolypeptide for potentially blocking influenza virus infection using a rat α2,6-sialyltransferase expressed in BmNPV bacmid-injected silkworm larvae

BMC Biotechnology, 2009
Background Sialic acid is a deoxy uronic acid with a skeleton of nine carbons which is mostly found on cell surface in animals. This sialic acid on cell surface performs various biological functions by acting as a receptor for microorganisms, viruses ...
Ogata Makoto, Nakajima Makoto, Kato Tatsuya, Obara Takakiyo, Yagi Hirokazu, Kato Koichi, Usui Taichi, Park Enoch Y   +7 more
doaj   +1 more source

Lymphangiogenesis: from the pig embryos to cancer [PDF]

, 2008
The discovery and the comprehension of lymphatic vessels suffered several historical delays and setbacks. The inherent anatomical problems slowed down the precise identification of the lymphatic system during the development of medical science.
Duarte, Maria, Longatto Filho, Adhemar, Schmitt, Fernando C.   +2 more
core   +3 more sources

Sialylation of prion protein controls the rate of prion amplification, the cross-species barrier, the ratio of PrPSc glycoform and prion infectivity.

PLoS Pathogens, 2014
The central event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrP(C)) into the disease-associated, transmissible form (PrP(Sc)).
Elizaveta Katorcha, Natallia Makarava, Regina Savtchenko, Alessandra D'Azzo, Ilia V Baskakov   +4 more
doaj   +1 more source