Abundance of intrinsically unstructured proteins in P. falciparum and other apicomplexan parasite proteomes [PDF]
Preliminary sequence analysis of Plasmodium falciparum has shown that the proteome of this organism is enriched in intrinsically unstructured proteins (IUPs), which are either completely disordered or contain large disordered regions.
Anders, R +5 more
core +1 more source
A Quinol Oxidase, Encoded by \u3cem\u3ecyoABCD\u3c/em\u3e, Is Utilized to Adapt to Lower O\u3csub\u3e2\u3c/sub\u3e Concentrations in \u3cem\u3eRhizobium etli\u3c/em\u3e CFN42 [PDF]
Bacteria have branched aerobic respiratory chains that terminate at different terminal oxidases. These terminal oxidases have varying properties such as their affinity for oxygen, transcriptional regulation and proton pumping ability.
Lunak, Zachary Ryan, Noel, K. Dale
core +1 more source
Insights into Vibrio cholerae Intestinal Colonization from Monitoring Fluorescently Labeled Bacteria [PDF]
Vibrio cholerae, the agent of cholera, is a motile non-invasive pathogen that colonizes the small intestine (SI). Most of our knowledge of the processes required for V.
Alvarez, David +5 more
core +3 more sources
Hyaluronan and chondroitin sulfate in chicken–vegetable bone broth delay osteoporosis progression
Abstract Bone broth has recently gained worldwide recognition as a superfood that supplements several nutrients lacking in modern human diets; however, little is known of its efficacy on osteoporosis. Therefore, we aimed to identify the components of chicken–vegetable bone broth (CVBB) that are associated with osteoporosis prevention and verified the ...
Yuka Seki +5 more
wiley +1 more source
A simple methodology to assess endolysosomal protease activity involved in antigen processing in human primary cells [PDF]
Background: Endolysosomes play a key role in maintaining the homeostasis of the cell. They are made of a complex set of proteins that degrade lipids, proteins and sugars. Studies involving endolysosome contribution to cellular functions such as MHC class
Boucau, Julie +7 more
core +1 more source
Sialidases are gradually entering various areas of human practice—in medicine and pharmacy, as antiviral, antitumor, diagnostic, and vaccine preparations; for the chemoenzymatic synthesis of regioselective sialoglycoconjugates; and for the structural ...
Yana Gocheva +4 more
doaj +1 more source
Escherichia coli K88 Interaction with IgA Oligosaccharides [PDF]
Diarrhea from enterotoxigenic Escherichia coli (E. coli) expressing the K88 fimbrial adhesin causes high morbidity and mortality among newborn and weaned piglets.
Acedo-Felix, Evelia +3 more
core
Th-MYCN Mice with Caspase-8 Deficiency Develop Advanced Neuroblastoma with Bone Marrow Metastasis [PDF]
Neuroblastoma, the most common extracranial pediatric solid tumor, is responsible for 15% of all childhood cancer deaths. Patients frequently present at diagnosis with metastatic disease, particularly to the bone marrow (BM).
Calabrese, Christopher +13 more
core +2 more sources
Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside molecules [PDF]
Recombinant human cytosolic sialidase (HsNEU2), expressed in Escherichia coli, was purified to homogeneity, and its substrate specificity was studied. HsNEU2 hydrolyzed 4-methylumbelliferyl alpha-NeuAc, alpha 2-->3 sialyllactose, glycoproteins (fetuin ...
BORSANI G +9 more
core
5. Vaccine development: basic considerations. Asexual blood stage vaccines: from merozoites to peptides [PDF]
Asexual blood stage proliferation is responsible for the morbidity and mortality associated with malaria infection in man. These developmental stages are therefore obvious targets for the development of malaria vaccines.
Fasani-Ghersa, P. +2 more
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