Results 61 to 70 of about 2,700 (196)

Antitumor Activities by a Humanized Cancer‐Specific Anti‐Podoplanin Monoclonal Antibody humPMab‐117 Against Human Tumors

Cancer Science, Volume 116, Issue 8, Page 2232-2242, August 2025.
A humanized cancer‐specific anti‐podoplanin monoclonal antibody humPMab‐117 exerts antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against human tumor cells. In the xenograft tumor models, humPMab‐117 demonstrated strong antitumor efficacy.
Tomohiro Tanaka, Hiroyuki Suzuki, Tomokazu Ohishi, Manabu Kawada, Mika K. Kaneko, Yukinari Kato   +5 more
wiley   +1 more source

Comparative Analysis of HMC3 and C20 Microglial Cell Lines Reveals Differential Myeloid Characteristics and Responses to Immune Stimuli

Immunology, Volume 175, Issue 1, Page 84-102, May 2025.
This study highlights comparative proteomic and morphological analyses of HMC3 and C20 microglial cell lines under baseline and inflammatory stimuli (LPS and IFN‐γ). Despite a 76.6% similarity in proteins, unstimulated HMC3 showed a transcriptional cell protein profile, whereas unstimulated C20 had a cell protein profile associated with the immune ...
Bavani Gunasegaran, Shivani Krishnamurthy, Sharron S. Chow, Millijoy D. Villanueva, Anna Guller, Seong Beom Ahn, Benjamin Heng   +6 more
wiley   +1 more source

Structural analysis of glycoprotein sialylation-part II: LC-MS based detection [PDF]

, 2013
Structural characterisation of sialylated glycoproteins in time and space is a requirement for further understanding of their involvement in biology.
Palmisano, Giuseppe, Giuseppe Palmisano, Packer, Nocolle H., Martin R. Larsen, Larsen, Martin R., Packer, Nicolle H., Morten Thaysen-Andersen, Thaysen-Andersen, Morten, Nicolle H. Packer, Larsen, Martin Røssel   +9 more
core   +1 more source

E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

Molecular Oncology, Volume 19, Issue 3, Page 635-658, March 2025.
Screening colorectal tumors for glycoproteins linked to disease progression has revealed several potential therapeutic targets. The secretin receptor (SCTR), identified as a marker of poor prognosis and metastasis in colorectal cancer, has been shown to be a key carrier of N‐glycans with sialylated Lewis antigens. These cancer‐specific glycoproteoforms
Sofia Cotton, Dylan Ferreira, Marta Relvas‐Santos, Andreia Brandão, Luís Pedro Afonso, Andreia Miranda, Eduardo Ferreira, Beatriz Santos, Martina Gonçalves, Paula Lopes, Lúcio Lara Santos, André M. N. Silva, José Alexandre Ferreira   +12 more
wiley   +1 more source

Erythrocyte glycophorins as receptors for Plasmodium merozoites

Parasites & Vectors, 2019
Glycophorins are heavily glycosylated sialoglycoproteins of human and animal erythrocytes. In humans, there are four glycophorins: A, B, C and D. Glycophorins play an important role in the invasion of red blood cells (RBCs) by malaria parasites, which ...
Ewa Jaskiewicz, Marlena Jodłowska, Radosław Kaczmarek, Agata Zerka   +3 more
doaj   +1 more source

Know Your ABCs: Discovery, Differentiation, and Targeting of T‐Bet+ B Cells

Immunological Reviews, Volume 330, Issue 1, March 2025.
ABSTRACT Since their first description in 2008, T‐bet+ B cells have emerged as a clinically important B cell subset. Now commonly known as ABCs (Age‐associated B Cells), they are uniquely characterized by their expression of the transcription factor T‐bet. Indeed, this singular factor defines this B cell subset.
Gary M. Winslow, Russell Levack
wiley   +1 more source

The Role of Sialic Acid-Binding Receptors (Siglecs) in the Immunomodulatory Effects of Trypanosoma cruzi Sialoglycoproteins on the Protective Immunity of the Host

Scientifica, 2013
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and is an important endemic infection in Latin America. Lately, it has also become a health concern in the United States and Europe.
Alexandre Morrot
doaj   +1 more source

Unveiling VCAM‐1’s Multifaceted Role in Secondary Diabetic Complications

Journal of Food Quality, Volume 2025, Issue 1, 2025.
Diabetes mellitus is a chronic metabolic disorder characterized by sustained hyperglycemia, tightly interlinked with a range of severe secondary complications. Diabetic retinopathy, nephropathy, and cardiomyopathy substantially contribute to the overall morbidity and mortality associated with diabetes.
Prabhnain Kaur, Ritu, Kalicharan Sharma, Ramesh K. Goyal, Parakh Basist, Rahmuddin Khan, Abdulsalam Alhalmi, Mohamed Addi   +7 more
wiley   +1 more source

Purification and characterization of 9-O-acetylated sialoglycoproteins from leukemic cells and their potential as immunological tool for monitoring childhood acute lymphoblastic leukemia [PDF]

, 2004
Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Exploiting the selective affinity of Achatinin-H toward N-acetyl-9-Oacetylneuraminic acid-a2-6-GalNAc, we have demonstrated the ...
Kohla, Guido, Isecke, Rainer, Merling, Anette, Schwartz-Albiez, Reinhard, Ghosh, Shyamasree, Bhattacharya, Dilip K, Bhattacharya, Dilip K., Mandal, Chhabinath, Schauer, Roland, Pal, Santanu, Brossmer, Reinhard, Mandal, Chitra   +11 more
core   +1 more source

Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation

Cell Reports
Summary: Neuraminidase 1 (NEU1) cleaves terminal sialic acids from sialoglycoproteins in endolysosomes and at the plasma membrane. As such, NEU1 regulates immune cells, primarily those of the monocytic lineage.
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d’Azzo   +5 more
doaj   +1 more source