Results 1 to 10 of about 20,212 (212)

Long-term sialidase-specific immune responses after natural infection with cholera: Findings from a longitudinal cohort study in Bangladesh

Frontiers in Immunology, 2022
BackgroundImmune responses that target sialidase occur following natural cholera and have been associated with protection against cholera. Sialidase is a neuraminidase that facilitates the binding of cholera toxin (CT) to intestinal epithelial cells ...
Fahima Chowdhury, Fahima Chowdhury, Afroza Akter, Taufiqur Rahman Bhuiyan, Rajib Biswas, Rajib Biswas, Md. Golam Firoj, Imam Tauheed, Jason B. Harris, Jason B. Harris, Regina C. Larocque, Regina C. Larocque, Allen G. Ross, Nigel A. J. McMillan, Richelle C. Charles, Richelle C. Charles, Richelle C. Charles, Edward T. Ryan, Edward T. Ryan, Edward T. Ryan, Stephen B. Calderwood, Stephen B. Calderwood, Stephen B. Calderwood, Firdausi Qadri   +23 more
doaj   +2 more sources

Visualization of sialidase activity in Mammalian tissues and cancer detection with a novel fluorescent sialidase substrate. [PDF]

PLoS ONE, 2014
Sialidase removes sialic acid from sialoglycoconjugates and plays crucial roles in many physiological and pathological processes. Various human cancers express an abnormally high level of the plasma membrane-associated sialidase isoform.Visualization of ...
Akira Minami, Tadamune Otsubo, Daisuke Ieno, Kiyoshi Ikeda, Hiroaki Kanazawa, Kosuke Shimizu, Ko Ohata, Tsunehiro Yokochi, Yuuki Horii, Hokuto Fukumoto, Risa Taguchi, Tadanobu Takahashi, Naoto Oku, Takashi Suzuki   +13 more
doaj   +2 more sources

Desialylation and sialidase secretion from monocytes and macrophages upon LPS activation [PDF]

Frontiers in Immunology
IntroductionThe cell surface expresses a dense layer of glycans often terminated with sialic acids (Sias), known as sialylation, which represents different cellular statuses.
Yu Zhao, Majdi Aljohani, Morgan Pychowycz, Xue-Long Sun   +3 more
doaj   +2 more sources

Development of mumps virus-specific sialidase imaging probes through chemical modifications of sialic acid [PDF]

Scientific Reports
Some viruses, such as mumps virus (MuV), possess sialidases that cleave terminal sialic acids, primarily N-acetylneuraminic acid (Neu5Ac), from glycans.
Yutaka Narimichi, Tadanobu Takahashi, Yuuki Kurebayashi, Tadamune Otsubo, Kiyoshi Ikeda, Yu Saito, Akira Minami, Hideyuki Takeuchi   +7 more
doaj   +2 more sources

Potency of bacterial sialidase Clostridium perfringens as antiviral of Newcastle disease infections using embryonated chicken egg in ovo model [PDF]

Veterinary World, 2022
Background and Aim: Clostridium toxins are widely used as medicinal agents. Many active metabolic enzymes, including sialidase (neuraminidase), hyaluronidase, and collagenase, contribute to the mechanism of action of these toxins.
Ryan Septa Kurnia, Simson Tarigan, Christian Marco Hadi Nugroho, Otto Sahat Martua Silaen, Lily Natalia, Fera Ibrahim, Pratiwi Pudjilestari Sudarmono   +6 more
doaj   +1 more source

Rational design of a new Trypanosoma rangeli trans-sialidase for efficient sialylation of glycans. [PDF]

PLoS ONE, 2014
This paper reports rational engineering of Trypanosoma rangeli sialidase to develop an effective enzyme for a potentially important type of reactivity: production of sialylated prebiotic glycans. The Trypanosoma cruzi trans-sialidase and the homologous T.
Carsten Jers, Malwina Michalak, Dorte M Larsen, Kasper P Kepp, Haiying Li, Yao Guo, Finn Kirpekar, Anne S Meyer, Jørn D Mikkelsen   +8 more
doaj   +1 more source

Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2

Scientific Reports, 2021
Reduction of elastin in the skin causes various skin diseases as well as wrinkles and sagging with aging. Sialidase is a hydrolase that cleaves a sialic acid residue from sialoglycoconjugate.
Akira Minami, Yuka Fujita, Jun Goto, Ayano Iuchi, Kosei Fujita, Yasuyo Mikami, Mako Shiratori, Ami Ishii, Samir Mitragotri, Yasunori Iwao, Hiroaki Kanazawa, Yuuki Kurebayashi, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki   +15 more
doaj   +1 more source

Clostridium perfringens sialidase interaction with Neu5Ac α-Gal sialic acid receptors by in-silico observation and its impact on monolayers cellular behavior structure

Journal of Advanced Veterinary and Animal Research, 2023
Objective: This study aims to evaluate the effect of Clostridium perfringens sialidase treatment on monolayer cell behavior using computational screening and an in vitro approach to demonstrate interaction between enzyme-based drugs and ligands in host ...
Ryan Septa Kurnia, Amin Soebandrio, Vivi Hardianty Harun, Christian Marco Hadi Nugroho, Desak Gede Budi Krisnamurti, Okti Nadia Poetri, Agustin Indrawati, Simson Tarigan, Ketut Karuni Nyanakumari Natih, Fera Ibrahim, Pratiwi Pudjilestari Sudarmono8, Otto Sahat Martua Silaen   +11 more
doaj   +1 more source

Screening and purification of NanB sialidase from Pasteurella multocida with activity in hydrolyzing sialic acid Neu5Acα(2–6)Gal and Neu5Acα(2–3)Gal

Scientific Reports, 2022
Study on sialidases as antiviral agents has been widely performed, but many types of sialidase have not been tested for their antiviral activity. Pasteurella multocida NanB sialidase is one such sialidase that has never been isolated for further research.
Christian Marco Hadi Nugroho, Ryan Septa Kurnia, Simson Tarigan, Otto Sahat Martua Silaen, Silvia Triwidyaningtyas, I. Wayan Teguh Wibawan, Lily Natalia, Andi Khomeini Takdir, Amin Soebandrio   +8 more
doaj   +1 more source

Role of Sialidase in Long-Term Potentiation at Mossy Fiber-CA3 Synapses and Hippocampus-Dependent Spatial Memory. [PDF]

PLoS ONE, 2016
Sialic acid bound to glycans in glycolipids and glycoproteins is essential for synaptic plasticity and memory. Sialidase (EC 3.2.1.18), which has 4 isozymes including Neu1, Neu2, Neu3 and Neu4, regulates the sialylation level of glycans by removing ...
Akira Minami, Masakazu Saito, Shou Mamada, Daisuke Ieno, Tomoya Hikita, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki   +8 more
doaj   +1 more source