Results 31 to 40 of about 26,062 (215)
Angewandte Chemie, EarlyView.We report plate‐based coupled assays to rapidly and quantitatively determine the activity and selectivity of mucin‐active carbohydrate sulfatases. This fluorogenic assay further enables inhibitor identification and allows determination of (sub‐)cellular location. ABSTRACT Sulfated glycans play a central role in human health and influence cell signaling,
Charles W. E. Tomlinson +5 more
wiley +2 more sources
BMC Research Notes, 2011 Background Sialidase is a well-known virulence factor of other respiratory pathogens, but was only recently documented to occur in some species of Mycoplasma.
Brown Daniel R, May Meghan
doaj +1 more source
Vaccination targeting a surface sialidase of P. acnes: implication for new treatment of acne vulgaris. [PDF]
PLoS ONE, 2008 Acne vulgaris afflicts more than fifty million people in the United State and the severity of this disorder is associated with the immune response to Propionibacterium acnes (P. acnes). Systemic therapies for acne target P.
Teruaki Nakatsuji +5 more
doaj +1 more source
Journal of Lipid Research, 2012 Lipoprotein metabolism is an important contributing factor in the development and progression of atherosclerosis. Plasma lipoproteins and their receptors are heavily glycosylated and sialylated, and levels of sialic acids modulate their biological ...
Abraham Yang +5 more
doaj +1 more source
Glycohistochemical study of the toadfish Halobatrachus didactylus (Scheider, 1801) stomach
Scientia Marina, 2009 Toadfish Halobatrachus didactylus gastric mucosa was studied using conventional and lectin histochemistry. Conventional histochemistry revealed neutral glycoconjugates predominating over acidic ones in the apical zone of both surface epithelial cells and
Salvatore Desantis +6 more
doaj +1 more source
Transmembrane Peptides as a New Strategy to Inhibit Neuraminidase-1 Activation
Frontiers in Cell and Developmental Biology, 2020 Sialidases, or neuraminidases, are involved in several human disorders such as neurodegenerative, infectious and cardiovascular diseases, and cancers.
Camille Albrecht +38 more
doaj +1 more source
Sialidases affect the host cell adherence and epsilon toxin-induced cytotoxicity of Clostridium perfringens type D strain CN3718. [PDF]
PLoS Pathogens, 2011 Clostridium perfringens type B or D isolates, which cause enterotoxemias or enteritis in livestock, produce epsilon toxin (ETX). ETX is exceptionally potent, earning it a listing as a CDC class B select toxin. Most C.
Jihong Li +4 more
doaj +1 more source
Synthesis of N-Glycolylneuraminic Acid (Neu5Gc) and Its Glycosides. [PDF]
, 2019 Sialic acids constitute a family of negatively charged structurally diverse monosaccharides that are commonly presented on the termini of glycans in higher animals and some microorganisms.
Chen, Xi +2 more
core +2 more sources
Unraveling the Differences of the Hydrolytic Activity of Trypanosoma cruzi trans-Sialidase and Trypanosoma rangeli Sialidase: A Quantum Mechanics–Molecular Mechanics Modeling Study [PDF]
, 2014 Chagas’ disease, also known as American trypanosomiasis, is a lethal, chronic disease that currently affects more than 10 million people in Central and South America. The trans-sialidase from Trypanosoma cruzi (T. cruzi, TcTS) is a crucial enzyme for the
Bueren Calabuig, Juan A. +2 more
core +1 more source
SIALIDASE ACTIVITY IN MYCOPLASMA SYNOVIAE [PDF]
Avian Diseases Digest, 2007 Eleven strains of the avian pathogen Mycoplasma synoviae were evaluated for the presence of sialidase activity with the use of the fluorogenic substrate 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid and the sialidase inhibitor 2-deoxy-2,3- didehydro-N-acetylneuraminic acid.
Meghan, May +2 more
openaire +2 more sources