Results 41 to 50 of about 20,212 (212)

Sialidases affect the host cell adherence and epsilon toxin-induced cytotoxicity of Clostridium perfringens type D strain CN3718. [PDF]

PLoS Pathogens, 2011
Clostridium perfringens type B or D isolates, which cause enterotoxemias or enteritis in livestock, produce epsilon toxin (ETX). ETX is exceptionally potent, earning it a listing as a CDC class B select toxin. Most C.
Jihong Li, Sameera Sayeed, Susan Robertson, Jianming Chen, Bruce A McClane   +4 more
doaj   +1 more source

Phloroglucinol as a Potential Candidate against Trypanosoma congolense Infection: Insights from In Vivo, In Vitro, Molecular Docking and Molecular Dynamic Simulation Analyses

Molecules, 2022
Sub-Saharan Africa is profoundly challenged with African Animal Trypanosomiasis and the available trypanocides are faced with drawbacks, necessitating the search for novel agents. Herein, the chemotherapeutic potential of phloroglucinol on T.
Nasirudeen Idowu Abdulrashid, Suleiman Aminu, Rahma Muhammad Adamu, Nasir Tajuddeen, Murtala Bindawa Isah, Isa Danladi Jatau, Abubakar Babando Aliyu, Mthokozisi Blessing Cedric Simelane, Elewechi Onyike, Mohammed Auwal Ibrahim   +9 more
doaj   +1 more source

Protein O-Glycosylation Shapes Lymphatic Endothelia and Lymph Node Macrophage Populations. [PDF]

FASEB J
To study the functional roles of O‐glycans on lymphatic endothelia, we deleted Cosmc, the chaperone required for core‐1 O‐glycan synthesis. Loss of core‐1 O‐glycans entailed major changes in glycoprotein composition of lymphatic endothelial cells (LEC), including reduced podoplanin (Pdpn), CD44, and Lyve‐1, and increased ICAM‐1; reduced CD44 was caused
Frey J, Ratter A, Brigger F, Cielen L, Kunz P, Tulin E, Mikos K, Dieterich L, D'Addio M, Halin C, Cummings RD, Otto VI.   +11 more
europepmc   +2 more sources

SIALIDASE ACTIVITY IN MYCOPLASMA SYNOVIAE [PDF]

Avian Diseases Digest, 2007
Eleven strains of the avian pathogen Mycoplasma synoviae were evaluated for the presence of sialidase activity with the use of the fluorogenic substrate 2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid and the sialidase inhibitor 2-deoxy-2,3- didehydro-N-acetylneuraminic acid.
Meghan, May, Stanley H, Kleven, Daniel R, Brown   +2 more
openaire   +2 more sources

Regulation of sialidase production in Clostridium perfringens by the orphan sensor histidine kinase ReeS. [PDF]

PLoS ONE, 2013
Clostridium perfringens is ubiquitous in nature and is often found as a commensal of the human and animal gastrointestinal tract. It is the primary etiological agent of clostridial myonecrosis, or gas gangrene, a serious infection that results in ...
Thomas J Hiscox, Paul F Harrison, Anjana Chakravorty, Jocelyn M Choo, Kaori Ohtani, Tohru Shimizu, Jackie K Cheung, Julian I Rood   +7 more
doaj   +1 more source

Relevance of the diversity among members of the Trypanosoma cruzi trans-sialidase family analyzed with camelids single-domain antibodies. [PDF]

PLoS ONE, 2008
The sialic acid present in the protective surface mucin coat of Trypanosoma cruzi is added by a membrane anchored trans-sialidase (TcTS), a modified sialidase that is expressed from a large gene family.
Laura Ratier, Mariela Urrutia, Gastón Paris, Laura Zarebski, Alberto C Frasch, Fernando A Goldbaum   +5 more
doaj   +1 more source

Novel Virulence Role of Pneumococcal NanA in Host Inflammation and Cell Death Through the Activation of Inflammasome and the Caspase Pathway

Frontiers in Cellular and Infection Microbiology, 2021
Streptococcus pneumoniae is one of most deadly Gram-positive bacterium that causes significant mortality and morbidity worldwide. Intense inflammation and cytotoxicity is a hallmark of invasive pneumococcal disease.
Yu-Wen Tseng, Chun-Chi Chang, Yung-Chi Chang   +2 more
doaj   +1 more source

Multivalent sialic acid binding proteins as novel therapeutics for influenza and parainfluenza infection [PDF]

, 2014
In nature, proteins with weak binding affinity often use a multivalency approach to enhance protein affinity via an avidity effect. Interested in this multivalency approach, we have isolated a carbohydrate binding module (CBM) that recognises sialic ...
Alias, Nadiawati
core   +2 more sources

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Gut microbiota dysbiosis‐mediated gut NLRP3 inflammasome activation exacerbates corticospinal tract injury after intracerebral hemorrhage

Interdisciplinary Medicine, EarlyView.
Schematic depicting a gut‐brain pathway that exacerbates CST injury after ICH. Gut Microbiota Dysbiosis‐Mediated Gut NLRP3 Inflammasome Activation Exacerbates Corticospinal Tract Injury After Intracerebral Hemorrhage. Abstract Intracerebral hemorrhage (ICH) causes severe neurological deficits largely attributable to corticospinal tract (CST) injury ...
Meiqin Zeng, Meichang Peng, Chen He, Yanmeng Zhao, Zizhang Cheng, Mengchen Yu, Hao Tian, Lu Zhang, Wen Yuan, Qing Zeng, Jiandong Huang, Haitao Sun   +11 more
wiley   +1 more source