Results 61 to 70 of about 26,062 (215)

Trans‐sialidase and Sialidase Activities Discriminate between Morphologically Indistinguishable Trypanosomatids [PDF]

European Journal of Biochemistry, 1994
The expression of trans‐sialidase and sialidase activities in the kinetoplastid protozoa was explored as a potential marker to discriminate between the morphologically indistinguishable flagellates isolated from human, insects and vertebrate reservoir hosts. By virtue of the differences observed in the ratios of these enzyme activities, a collection of
Medina-acosta, E., Pereira, Antonia Maria Ramos Franco, Jansen-franken, Ana Maria, Sampol, M., Neves, N., Carvalho, L. Pontes, Grimaldi, G., Nussenzweig, V.   +7 more
openaire   +2 more sources

Cryo‐EM structure of GH43 β‐Xylosidase from Enterobacter cloacae provides insights into substrate specificity and the role of an auxiliary domain in enzymatic activity

The FEBS Journal, EarlyView.
Xylan, the second most abundant plant cell wall polysaccharide, is degraded by β‐xylanases and β‐xylosidases. Here, we present the 2.65 Å cryo‐EM structure of Enterobacter cloacae β‐xylosidase (EcXyl43, GH43) and the 2.4 Å X‐ray structure of its inactive F507A mutant.
Lorenzo Briganti, Andre Schutzer Godoy, Caio Cesar Mello Capetti, Rafaela Sachetto Fernandes, Vanessa O. A. Pellegrini, Ornella M. Ontañon, Eleonora Campos, Rodrigo V. Portugal, Igor Polikarpov   +8 more
wiley   +1 more source

Inhibitors of Human Neuraminidase Enzymes Block Transmigration in vitro

Frontiers in Molecular Biosciences, 2022
Cell migration to a site of inflammation is an important step of the immune response. This process is coordinated by cytokines, receptors, and the signal processing machinery of the cell.
Md. Amran Howlader, Tianlin Guo, Christopher W. Cairo   +2 more
doaj   +1 more source

A posttranslational proteomic survey of a single anatomically preserved human 20‐week postconception brain

Journal of Anatomy, EarlyView.
A well‐preserved 20 post‐conception week human brain was obtained and finely dissected into 18 anatomically distinct regions, including the pia mater. Each region underwent in‐depth proteomic analysis, encompassing both total protein content and post‐translational modifications.
S. Bandiera, H. Bogetofte, P. Jensen, R. Hussain, S. A. Nischal, L. Rihova, G. J. Clowry, M. R. Larsen, Z. Molnár, B. C. Carlyle   +9 more
wiley   +1 more source

Vaginal hydrolytic enzymes, immunoglobulin A against Gardnerella vaginalis toxin, and risk of early preterm birth among women in preterm labor with bacterial vaginosis or intermediate flora [PDF]

, 2002
Objective: The purpose of this study was to determine whether the microbial hydrolytic enzymes, sialidase and prolidase, and immunoglobulin A against the Gardnerella vaginalis cytolysin (anti-Gvh IgA) increase the risk for early preterm birth ( 6434 ...
Agnew, K, Cauci, S, Eschenbach, DA., Hillier, SL, Hitti, J, Noonan, C, Quadrifoglio, F   +6 more
core   +1 more source

Sialidase in rabbit blood [PDF]

European Journal of Biochemistry, 1994
Sialidase activities of rabbit blood cells and serum were measured. The leucocyte particulate fraction showed the highest specific activity of sialidase towards mixed gangliosides and sialyllactose, and the cytosolic fraction showed for fetuin. Predominant sialidase activity in the blood was detected in erythrocyte particulate fraction when mixed ...
X G, Chen, T, Nagai, H, Yamada
openaire   +2 more sources

Sialidase Inhibitors with Different Mechanisms

Journal of Medicinal Chemistry, 2022
Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus often involved in biological pathways.
Joseph M. Keil, Garrett R. Rafn, Isaac M. Turan, Majdi A. Aljohani, Reza Sahebjam-Atabaki, Xue-Long Sun   +5 more
openaire   +2 more sources

One‐Step Glycoengineering of NK Cells With High‐Affinity Siglec Ligands for Cancer Immunotherapy

Advanced Science, Volume 13, Issue 26, 8 May 2026.
This study develops an engineered NmCSS enzyme with improved activity for bulky group modified sialic acids, enabling efficient synthesis of structurally diverse sialoside analogs in a single step. Glycan microarray screening identified Siglec high‐affinity ligands, which were incorporated onto natural killer (NK) cells via a one‐pot enzymatic system ...
Shuai Hu, Ben Huang, Lingyan Wang, Qiang Guo, Cuiping Jiang, Ruicheng Qi, Shuyao Wang, Lin‐Tai Da, Wenjie Peng   +8 more
wiley   +1 more source

Siglec-E promotes β2-integrin-dependent NADPH oxidase activation to suppress neutrophil recruitment to the lung [PDF]

, 2014
Siglec-E is a sialic acid-binding Ig-like lectin expressed on murine myeloid cells. It has recently been shown to function as a negative regulator of β2-integrin-dependent neutrophil recruitment to the lung following exposure to lipopolysaccharide (LPS).
Anderson, Boyle, Boyle, Chen, Chen, Doerschuk, Fisher, Franke, Gao, Grommes, Hoyal, Kielland, Kulkarni, Liu, Matthay, McMillan, Mócsai, Pollock, Segal, Segal, Segal, Zhang, Zhang, Zhang   +23 more
core   +3 more sources

Glucose Catabolite Repression Participates in the Regulation of Sialidase Biosynthesis by Antarctic Strain Penicillium griseofulvum P29

Journal of Fungi
Sialidases (neuraminidases) catalyze the removal of terminal sialic acid residues from glycoproteins. Novel enzymes from non-clinical isolates are of increasing interest regarding their application in the food and pharmaceutical industry.
Radoslav Abrashev, Ekaterina Krumova, Penka Petrova, Rumyana Eneva, Vladislava Dishliyska, Yana Gocheva, Stefan Engibarov, Jeny Miteva-Staleva, Boryana Spasova, Vera Kolyovska, Maria Angelova   +10 more
doaj   +1 more source