Desialylation and Apoptosis in Immune Thrombocytopenia: Implications for Pathogenesis and Treatment [PDF]
Current Issues in Molecular BiologyImmune thrombocytopenia (ITP) is an autoimmune disease in which platelet autoantibodies play a significant role in its pathogenesis. Regulatory T cell dysfunction and T cell-mediated cytotoxicity also contribute to thrombocytopenia. Current therapies are
Shiying Zheng
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Platelet desialylation, apoptosis, and T-lymphocyte-mediated immune dysregulation: unveiling the pathways of platelet clearance in platelet transfusion refractoriness [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Platelet transfusion refractoriness (PTR) is a clinical challenge that can be classified into nonimmunologic and immunologic types, the latter resulting from both platelet alloimmunization and autoimmunity.
Yan Zhou +8 more
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The role of platelet desialylation as a biomarker in primary immune thrombocytopenia: mechanisms and therapeutic perspectives [PDF]
Frontiers in ImmunologyPrimary immune thrombocytopenia (ITP) is an acquired autoimmune disorder characterized by the destruction of platelets. Although it was long believed that the critical role of autoantibodies in platelet destruction, primarily through the Fc-dependent ...
Jiesi Luo, Jianming Wu
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Desialylation and sialidase secretion from monocytes and macrophages upon LPS activation [PDF]
Frontiers in ImmunologyIntroductionThe cell surface expresses a dense layer of glycans often terminated with sialic acids (Sias), known as sialylation, which represents different cellular statuses.
Yu Zhao +3 more
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Biochemistry and Biophysics Reports, 2021 Background: Sialic acids are widely distributed in nature and have biological relevance owing to their varied structural and functional roles. Immobilized neuraminidase can selectively remove terminal N-acetyl neuraminic acid from glycoproteins without ...
Maria Florencia Festari +2 more
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Frontiers in Immunology, 2022 Thrombocytopenia is a multifactorial condition that frequently involves concomitant defects in platelet production and clearance. The physiopathology of low platelet count in thrombocytopenia remains unclear. Sialylation on platelet membrane glycoprotein
Jianda Hu, Yingyu Chen, Qizhen Shi
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Decoding sialidase: physiological roles, pathological pathways, and clinical opportunities [PDF]
Frontiers in Cellular and Infection MicrobiologyThis review critically examines pathological dysregulation of sialidase across genetic syndromes, infectious pathogens, inflammatory/autoimmune disorders, malignant transformations, and neurodegenerative cascades, revealing molecular mechanisms that ...
Rushi Li +3 more
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Cells, 2020 Cancer stem cells (CSCs) are crucial regulators of tumor recurrence/progression. The maintenance of CSCs is dependent on aberrant activation of various pathways, including Hedgehog. Prevalent sialylations contribute to aggressiveness in CSCs.
Chitra Mandal +2 more
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Modulating the sialic acid content of endothelial cells affects their adhesion and barrier permeability [PDF]
Scientific ReportsThe crossing of the endothelial cell layer and the glycocalyx that shields it can be considered the final barrier for substances trying to pass from the blood into the surrounding tissue.
Paula M. Müller +4 more
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Platelet aging and desialylation increase apoptotic priming and BCL-XL dependence [PDF]
Cell Death and DiseasePlatelets are short-lived anucleate cells essential for primary hemostasis and recognized for their functions in thrombosis, immunity, antimicrobial defense, neurodegeneration, as well as cancer growth and metastasis.
Renata Grozovsky +4 more
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