Results 41 to 50 of about 3,518 (193)
Platelet desialylation and TFH cells–the novel pathway of immune thrombocytopenia
Experimental Hematology & Oncology, 2021 Immune thrombocytopenia (ITP) is an autoimmune disease characterized by immune-mediated destruction of one’s own platelets. The progression of thrombocytopenia involves an imbalance of platelet production and clearance. B cells can induce autoantibodies,
Yuwen Chen, Jianda Hu, Yingyu Chen
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Haematologica, 2019 Patients with type 2B von Willebrand disease (vWD) (caused by gain-of-function mutations in the gene coding for von Willebrand factor) display bleeding to a variable extent and, in some cases, thrombocytopenia.
Annabelle Dupont +22 more
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Sialidase Activity in Human Blood Serum Has a Distinct Seasonal Pattern: A Pilot Study
Biology, 2020 Desialylation—loss of terminal sialic acid residues from glycoconjugates catalyzed by sialidases—is involved in many human diseases and is considered a key molecular event of atherosclerosis onset.
Victor Y. Glanz +5 more
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Effects of genetic variants and sialylation on in vitro digestibility of purified κ-casein
Journal of Dairy Science, 2022 : Milk with different κ-casein (CN) phenotypes has previously been found to influence its gastric digestion rate. Therefore, the aim of the present study is to disentangle contributions of genetic variation and its related sialylation on the in vitro ...
Bulei Sheng +5 more
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The role of neuraminidase 1 and 2 in glycoprotein Ibα-mediated integrin αIIbβ3 activation
Haematologica, 2020 Upon vascular injury, platelets adhere to von Willebrand Factor (VWF) via glycoprotein Ibα (GPIbα). GPIbα contains many glycans, capped by sialic acid. Sialic acid cleavage (desialylation) triggers clearance of platelets.
Dianne E. van der Wal +3 more
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Cells, 2022 Hepatocellular carcinoma (HCC) is one of the dominating causes of cancer-related death throughout the world. Treatment options for patients with HCC vary, however, the lack of effective targeted drugs is the major reason for death in advanced HCC ...
Chunyan Yang +6 more
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Molecules, 2022 Venom-induced thrombocytopenia (VIT) is one of the most important hemotoxic effects of a snakebite, which is often associated with venom-induced consumptive coagulopathy (VICC).
Cheng Zhang +8 more
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Optimization of enzymatic desialylation of human serum transferrin [PDF]
Macedonian Pharmaceutical Bulletin, 2022 Optimization of desialylation process of human serum transferrin was performed for 2 different commercially available sialidase enzymes. To confirm the extent of desialylation, the collected protein samples were analyzed by fast protein liquid chromatography. Increasing the protein mass per single cycle together with a drastic increase in reaction time
Friganović, Tomislav +2 more
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, 2022 Thrombocytopenia is a multifactorial condition that frequently involves concomitant defects in platelet production and clearance. The physiopathology of low platelet count in thrombocytopenia remains unclear. Sialylation on platelet membrane glycoprotein
Qiaoyun Zheng (12332060) +11 more
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NEU1 is more abundant in uveitic retina with concomitant desialylation of retinal cells.
, 2021 Desialylation of cell surface glycoproteins carried out by sialidases affects various immunological processes. However, the role of neuraminidase 1 (NEU1), one of four mammalian sialidases, in inflammation and autoimmune disease is not completely ...
Amann, B. +5 more
core +1 more source