Results 31 to 40 of about 3,518 (193)

The Elastin Receptor Complex: An Emerging Therapeutic Target Against Age-Related Vascular Diseases

Frontiers in Endocrinology, 2022
The incidence of cardiovascular diseases is increasing worldwide with the growing aging of the population. Biological aging has major influence on the vascular tree and is associated with critical changes in the morphology and function of the arterial ...
Dignê Tembely, Aubéri Henry, Laetitia Vanalderwiert, Kevin Toussaint, Amar Bennasroune, Sébastien Blaise, Hervé Sartelet, Stéphane Jaisson, Céline Galés, Laurent Martiny, Laurent Duca, Béatrice Romier-Crouzet, Pascal Maurice   +12 more
doaj   +1 more source

Do platelets prematurely age in canine immune thrombocytopenia (ITP)? Development of a novel flow cytometric assay to assess the role of platelet desialylation in ITP pathogenesis [PDF]

, 2023
Immune thrombocytopenia (ITP) is an aggressive hemostatic disorder of dogs with significant morbidity and mortality. In this autoimmune disease, anti-platelet antibodies promote platelet destruction.
Barchilon, Michael
core   +1 more source

Thirty-Five-Year History of Desialylated Lipoproteins Discovered by Vladimir Tertov

Biomedicines, 2022
Atherosclerosis is one of the leading causes of death in developed and developing countries. The atherogenicity phenomenon cannot be separated from the role of modified low-density lipoproteins (LDL) in atherosclerosis development.
Victor Glanz, Evgeny E. Bezsonov, Vladislav Soldatov, Alexander N. Orekhov   +3 more
doaj   +1 more source

Influence of desialylation of caseinomacropeptide on the denaturation and aggregation of whey proteins [PDF]

Journal of Dairy Science, 2020
The effect of the addition of caseinomacropeptide (CMP) or desialylated CMP on the heat-induced denaturation and aggregation of whey proteins was investigated in the pH range 3 to 7 after heating at 80°C for 30 min. The rate and temperature of denaturation, the extent of aggregation, and the changes in secondary structure of the whey proteins heated in
Gaspard, Sophie J., Sunds, Anne V., Larsen, Lotte B.; id_orcid 0000-0001-9674-0107, Poulsen, Nina A.; id_orcid 0000-0001-9983-9663, O'Mahony, James A., Kelly, Alan L., Brodkorb, André   +6 more
openaire   +3 more sources

Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration

Frontiers in Cellular Neuroscience, 2020
Microglia are brain macrophages that mediate neuroinflammation and contribute to and protect against neurodegeneration. The terminal sugar residue of all glycoproteins and glycolipids on the surface of mammalian cells is normally sialic acid, and ...
Mar Puigdellívol, David H. Allendorf, Guy C. Brown   +2 more
doaj   +1 more source

Effect of desialylation on the biological properties of human plasminogen [PDF]

Biochemical Journal, 1992
There are two major isoenzymes of plasminogen (Pg) in human plasma, designated Pg1 and Pg2. Both Pg forms have an identical primary structure, but differ in their extent of glycosylation. Removal of the oligosaccharide chains alters the normal physiological function of the zymogen and decreases the circulation time of both Pg glycoforms. Recent studies
M S, Stack, S V, Pizzo, M, Gonzalez-Gronow   +2 more
openaire   +2 more sources

Neu1 Is Released From Activated Microglia, Stimulating Microglial Phagocytosis and Sensitizing Neurons to Glutamate

Frontiers in Cellular Neuroscience, 2022
Neuraminidase 1 (Neu1) hydrolyses terminal sialic acid residues from glycoproteins and glycolipids, and is normally located in lysosomes, but can be released onto the surface of activated myeloid cells and microglia.
David H. Allendorf, Guy C. Brown
doaj   +1 more source

Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site. [PDF]

Eur J Immunol
This study shows that loss of sialylation in CT26 cells reduces peritoneal tumor burden, correlating with a lower peritoneal cancer index score. These tumors exhibited increased immune infiltration with prominent alterations in the myeloid compartment and immune cell correlations unique to desialylated tumors, indicating profound reshaping of antitumor
van der Haar Àvila I, Lenos K, Lorrain V, Nardini E, Rodríguez E, García-Vallejo JJ, van Kooyk Y, Grootjans J, van Vliet SJ.   +8 more
europepmc   +2 more sources

Catabolism of Desialylated Ceruloplasmin in the Liver

Journal of Biological Chemistry, 1970
Abstract When desialylated ceruloplasmin (ASCPN), labeled with 64Cu and with 3H in its galactose residues, is injected intravenously into a rat, more than half of the radioactivity can be recovered within minutes in ASCPN precipitated immunochemically from liver homogenates.
G, Gregoriadis, A G, Morell, I, Sternlieb, I H, Scheinberg   +3 more
openaire   +2 more sources

Circulating desialylated low density lipoprotein [PDF]

Cor et Vasa, 2017
Hromaděni lipidů představuje hlavni faktor v rozvoji aterosklerotických změn. Je znamo, že castice lipoproteinů o nizke hustotě (low-density lipoprotein, LDL) jsou hlavnim zdrojem cholesterolu a dalsich lipidů uložených v aterosklerotickem platu. Aterogenni vlastnosti vsak nemaji vsechny LDL castice. Hromaděni lipidů v buňkach tepen vyžaduje modifikaci
Alexander N. Orekhov, Ekaterina A. Ivanova, Alexandra A. Melnichenko, Igor A. Sobenin   +3 more
openaire   +1 more source