Results 21 to 30 of about 3,518 (193)

Investigating the role of low-level ST6Gal-Ⅰ-mediated CD36 desialylation in ITP based on the MEG-01 cell model

Zhongguo shuxue zazhi
[Objective] To investigate the correlation among α2, 6-sialyltransferase (ST6Gal-Ⅰ), CD36 desialylation, and caveolin-1 (Cav-1) in phorbol ester (PMA)-induced MEG-01 cell model, as well as their potential mechanism in immune thrombocytopenia (ITP ...
FAN Na, ZHONG Lei, LIU Wen, TONG Anqi, LIANG Jing   +4 more
doaj   +2 more sources

Platelet desialylation is a novel mechanism and a therapeutic target in thrombocytopenia during sepsis: an open-label, multicenter, randomized controlled trial

Journal of Hematology & Oncology, 2017
Background Studies in murine models suggested that platelet desialylation was an important mechanism of thrombocytopenia during sepsis. Methods First, we performed a prospective, multicenter, observational study that enrolled septic patients with or ...
Mei-feng Li, Xiao-li Li, Kai-liang Fan, Ying-yi Yu, Jing Gong, Shu-ying Geng, Ya-feng Liang, Ling Huang, Ji-hua Qiu, Xing-han Tian, Wen-ting Wang, Xiao-lu Zhang, Qing-xia Yu, Yuan-feng Zhang, Peng Lin, Li-na Wang, Xin Li, Ming Hou, Lu-yi Liu, Jun Peng   +19 more
doaj   +2 more sources

Platelet storage induces accelerated desialylation of platelets and increases hepatic thrombopoietin production [PDF]

Journal of Translational Medicine, 2018
Background Stored platelets undergo deleterious changes, referred to as platelet storage lesions (PSLs), which accelerate the desialylation of platelets and result in their phagocytosis and clearance by hepatic macrophages.
Jooyoung Cho, Hyunkyung Kim, Jaewoo Song, June-Won Cheong, Jeong Won Shin, Woo Ick Yang, Hyun Ok Kim   +6 more
doaj   +3 more sources

Clinical application of a modified platelet desialylation test for mechanistic characterization of platelet transfusion refractoriness. [PDF]

Transfusion
Abstract Background Platelet transfusion refractoriness (PTR) is a major challenge in transfusion medicine and may result from both immune and non‐immune mechanisms. Although alloantibodies are well‐established contributors, Fc‐independent pathways such as platelet desialylation have emerged as alternative mechanisms of clearance.
Ziza K, Silva T, Domentino M, Conrado M, Oliveira J, Moritz E, Chiba A, Rocha V, Mendrone-Junior A, Bordin J, Dante L, Dinardo C.   +11 more
europepmc   +2 more sources

Proatherogenic Sialidases and Desialylated Lipoproteins: 35 Years of Research and Current State from Bench to Bedside

Biomedicines, 2021
This review summarizes the main achievements in basic and clinical research of atherosclerosis. Focusing on desialylation as the first and the most important reaction of proatherogenic pathological cascade, we speak of how desialylation increases the ...
Alexandre Mezentsev, Evgeny Bezsonov, Dmitry Kashirskikh, Mirza S. Baig, Ali H. Eid, Alexander Orekhov   +5 more
doaj   +1 more source

Functional Specialization of Clathrin-Independent Endocytic Routes: Mechanisms and Cellular Roles. [PDF]

Traffic
Distinct clathrin‐independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com. ABSTRACT Clathrin‐independent endocytosis (CIE) comprises a diverse repertoire of internalization mechanisms that operate in parallel with clathrin‐mediated endocytosis.
Benvenuto AF, Fardin A, Balestra M, Di Fiore PP, Tordonato C, Sigismund S.   +5 more
europepmc   +2 more sources

From Platelet Toxicity to Precision Targeting: Evolving Strategies to Overcome Thrombocytopenia in BCL-2/BCL-XL Inhibition. [PDF]

Health Sci Rep
ABSTRACT Background Simultaneous blockade of the anti‐apoptotic proteins BCL‐2 and BCL‐XL has been shown to be efficacious in preclinical and clinical trials for tumors that are co‐dependent on their survival pathways, although clinical development has been limited owing to dose‐limiting thrombocytopenia associated with BCL‐XL inhibition.
Mohiuddin M.
europepmc   +2 more sources

Influenza virus infection of desialylated cells [PDF]

Glycobiology, 2000
Sialic acid has long been considered to be the sole receptor for influenza virus. The viral hemagglutinin (HA) is known to bind cell surface sialic acid, and sialic acids on viral glyco-proteins are cleaved by the viral neuraminidase (NA) to promote efficient release of progeny virus particles.
S J, Stray, R D, Cummings, G M, Air
openaire   +2 more sources

Current therapeutic strategies and perspectives in refractory ITP: What have we learned recently?

Frontiers in Immunology, 2022
Immune thrombocytopenia (ITP) is an acquired autoimmune bleeding disorder featured by increased platelet destruction and deficient megakaryocyte maturation.
Yue Lv, Huiping Shi, Hong Liu, Lu Zhou
doaj   +1 more source

Low-pressure chromatographic separation and UV/Vis spectrophotometric characterization of the native and desialylated human apo-transferrin

Heliyon, 2021
Low-pressure pH gradient ion exchange separation provides a fast, simple and cost-effective method for preparative purification of native and desialylated apo-transferrin. The method enables easy monitoring of the extent of the desialylation reaction and
Tomislav Friganović, Antonela Tomašić, Tino Šeba, Ivan Biruš, Robert Kerep, Valentina Borko, Davor Šakić, Mario Gabričević, Tin Weitner   +8 more
doaj   +1 more source