Results 11 to 20 of about 3,518 (193)

Desialylation of Blood Plasma Lipoproteins by Exogenous Sialidase

Medical Sciences Forum, 2022
Objective: Sialidases can play an important role in atherosclerosis development due to modification of low-density lipoproteins (LDL). It is known that desialylated LDLs are associated with atherosclerosis development.
Evgeny Bezsonov, Dmitry Kashirskikh
doaj   +3 more sources

Influence of Desialylation on the Drug Binding Affinity of Human Alpha-1-Acid Glycoprotein Assessed by Microscale Thermophoresis

Pharmaceutics
Human serum alpha-1-acid glycoprotein (AAG) is an acute-phase plasma protein involved in the binding and transport of many drugs, especially basic and lipophilic substances.
Gordan Lauc, Toma Keser, Tin Weitner
exaly   +4 more sources

Platelet desialylation correlates with efficacy of first-line therapies for immune thrombocytopenia [PDF]

Journal of Hematology & Oncology, 2017
Immune thrombocytopenia (ITP) is a common autoimmune bleeding disorder. Despite considerable investigation, the pathogenesis of ITP remains incompletely understood, and for many patients, effective therapy is still unavailable. Using murine models and in
Lili Tao, Qingshu Zeng, June Li, Miao Xu, Jiajia Wang, Ying Pan, Huiping Wang, Qianshan Tao, Yang Chen, Jun Peng, Ming Hou, Arend Jan Gerard Jansen, Heyu Ni, Zhimin Zhai   +13 more
doaj   +3 more sources

Antiplatelet antibody predicts platelet desialylation and apoptosis in immune thrombocytopenia [PDF]

Haematologica, 2022
Immune thrombocytopenia (ITP) is a bleeding disorder caused by dysregulated B- and T- cell functions, which lead to platelet destruction. A well-recognized mechanism of ITP pathogenesis involves anti-platelet and anti-megakaryocyte antibodies ...
Shiying Silvia Zheng, Zohra Ahmadi, Halina Hoi Laam Leung, Rose Wong, Feng Yan, Jose Sail Perdomo, Beng Hock Chong   +6 more
doaj   +2 more sources

Autoantibody-mediated desialylation impairs human thrombopoiesis and platelet lifespan [PDF]

Haematologica, 2019
Immune thrombocytopenia is a common bleeding disease caused by autoantibody-mediated accelerated platelet clearance and impaired thrombopoiesis. Accumulating evidence suggests that desialylation affects platelet life span in immune thrombocytopenia ...
Irene Marini, Jan Zlamal, Christoph Faul, Ursula Holzer, Stefanie Hammer, Lisann Pelzl, Wolfgang Bethge, Karina Althaus, Tamam Bakchoul   +8 more
doaj   +2 more sources

Functional validation of a modified platelet desialylation test for immune and hereditary thrombocytopenias

Transfusion Medicine, EarlyView.
Abstract Background Thrombocytopenia arises from heterogeneous inherited and acquired disorders, and identifying the underlying platelet clearance mechanisms remains challenging. Platelet desialylation, characterised by loss of sialic acid and consequent exposure of terminal β‐galactose residues recognised by the Ashwell–Morell receptor, represents an ...
Karen Nogueira Chinoca Ziza, Thamy Caroline Silva, Mateus Domentino, Marina Cavalcanti Albuquerque Veiga Conrado, João Vitor Bernardo Oliveira, Felipe Augusto Rós, Caroline Gabe, Elyse Moritz, Akemi Chiba, Paula Villaça, Vanderson Rocha, Alfredo Mendrone‐Junior, José Bordin, Dante Langhi, Carla Luana Dinardo   +14 more
wiley   +2 more sources

Possible involvement of radical reactions in desialylation of LDL [PDF]

FEBS Letters, 1997
The role of oxidatively modified LDL in the pathogenesis of atherosclerosis has been well documented. These studies have focused on modifications of lipid and protein parts of LDL. Recently desialylated LDL has received attention in relation to atherosclerosis and coronary artery disease.
Tanaka, Kyoko, Tokumaru, Sadako, Kojo, Shosuke   +2 more
openaire   +3 more sources

Role of Neuraminidase-mediated Desialylation in Microglial Activation [PDF]

, 2021
Microglia are the innate immune cells of the central nervous system (CNS) and play key roles in mediating the removal of dead or dying neurons, neurotoxic aggregates or neuronal debris, thus contributing to CNS health. Research in the recent years however has linked microglial activity to neurodegenerative processes brought about by excessive phagocyto-
openaire   +3 more sources

Desialylation of O-glycans on glycoprotein Ibα drives receptor signaling and platelet clearance [PDF]

Haematologica, 2020
During infection neuraminidase desialylates platelets and induces their rapid clearance from circulation. The underlying molecular basis, particularly the role of platelet glycoprotein (GP)Ibα therein, is not clear. Utilizing genetically altered mice we
Yingchun Wang, Wenchun Chen, Wei Zhang, Melissa M. Lee-Sundlov, Caterina Casari, Michael C. Berndt, Francois Lanza, Wolfgang Bergmeier, Karin M. Hoffmeister, X. Frank Zhang, Renhao Li   +10 more
doaj   +3 more sources

Desialylation of platelets induced by Von Willebrand Factor is a novel mechanism of platelet clearance in dengue. [PDF]

PLoS Pathogens, 2019
Thrombocytopenia and platelet dysfunction are commonly observed in patients with dengue virus (DENV) infection and may contribute to complications such as bleeding and plasma leakage.
Silvita Fitri Riswari, Rahajeng N Tunjungputri, Vesla Kullaya, Fadel M Garishah, Gloria S R Utari, Nur Farhanah, Gijs J Overheul, Bachti Alisjahbana, M Hussein Gasem, Rolf T Urbanus, Philip G de Groot, Dirk J Lefeber, Ronald P van Rij, Andre van der Ven, Quirijn de Mast   +14 more
doaj   +4 more sources