Results 11 to 20 of about 26,062 (215)

Potency of bacterial sialidase Clostridium perfringens as antiviral of Newcastle disease infections using embryonated chicken egg in ovo model [PDF]

Veterinary World, 2022
Background and Aim: Clostridium toxins are widely used as medicinal agents. Many active metabolic enzymes, including sialidase (neuraminidase), hyaluronidase, and collagenase, contribute to the mechanism of action of these toxins.
Ryan Septa Kurnia, Simson Tarigan, Christian Marco Hadi Nugroho, Otto Sahat Martua Silaen, Lily Natalia, Fera Ibrahim, Pratiwi Pudjilestari Sudarmono   +6 more
doaj   +1 more source

Desialylation and sialidase secretion from monocytes and macrophages upon LPS activation. [PDF]

Front Immunol
IntroductionThe cell surface expresses a dense layer of glycans often terminated with sialic acids (Sias), known as sialylation, which represents different cellular statuses.
Zhao Y, Aljohani M, Pychowycz M, Sun XL.
europepmc   +2 more sources

Long-term sialidase-specific immune responses after natural infection with cholera: Findings from a longitudinal cohort study in Bangladesh

Frontiers in Immunology, 2022
BackgroundImmune responses that target sialidase occur following natural cholera and have been associated with protection against cholera. Sialidase is a neuraminidase that facilitates the binding of cholera toxin (CT) to intestinal epithelial cells ...
Fahima Chowdhury, Fahima Chowdhury, Afroza Akter, Taufiqur Rahman Bhuiyan, Rajib Biswas, Rajib Biswas, Md. Golam Firoj, Imam Tauheed, Jason B. Harris, Jason B. Harris, Regina C. Larocque, Regina C. Larocque, Allen G. Ross, Nigel A. J. McMillan, Richelle C. Charles, Richelle C. Charles, Richelle C. Charles, Edward T. Ryan, Edward T. Ryan, Edward T. Ryan, Stephen B. Calderwood, Stephen B. Calderwood, Stephen B. Calderwood, Firdausi Qadri   +23 more
doaj   +1 more source

Visualization of sialidase activity in Mammalian tissues and cancer detection with a novel fluorescent sialidase substrate. [PDF]

PLoS ONE, 2014
Sialidase removes sialic acid from sialoglycoconjugates and plays crucial roles in many physiological and pathological processes. Various human cancers express an abnormally high level of the plasma membrane-associated sialidase isoform.Visualization of ...
Akira Minami, Tadamune Otsubo, Daisuke Ieno, Kiyoshi Ikeda, Hiroaki Kanazawa, Kosuke Shimizu, Ko Ohata, Tsunehiro Yokochi, Yuuki Horii, Hokuto Fukumoto, Risa Taguchi, Tadanobu Takahashi, Naoto Oku, Takashi Suzuki   +13 more
doaj   +1 more source

Enhancement of elastin expression by transdermal administration of sialidase isozyme Neu2

Scientific Reports, 2021
Reduction of elastin in the skin causes various skin diseases as well as wrinkles and sagging with aging. Sialidase is a hydrolase that cleaves a sialic acid residue from sialoglycoconjugate.
Akira Minami, Yuka Fujita, Jun Goto, Ayano Iuchi, Kosei Fujita, Yasuyo Mikami, Mako Shiratori, Ami Ishii, Samir Mitragotri, Yasunori Iwao, Hiroaki Kanazawa, Yuuki Kurebayashi, Tadanobu Takahashi, Tadamune Otsubo, Kiyoshi Ikeda, Takashi Suzuki   +15 more
doaj   +1 more source

NEU3 (sialidase 3 (membrane sialidase)) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on NEU3 (sialidase 3 (membrane sialidase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Yamaguchi, K, Miyagi, T
openaire   +2 more sources

Clostridium perfringens sialidase interaction with Neu5Ac α-Gal sialic acid receptors by in-silico observation and its impact on monolayers cellular behavior structure

Journal of Advanced Veterinary and Animal Research, 2023
Objective: This study aims to evaluate the effect of Clostridium perfringens sialidase treatment on monolayer cell behavior using computational screening and an in vitro approach to demonstrate interaction between enzyme-based drugs and ligands in host ...
Ryan Septa Kurnia, Amin Soebandrio, Vivi Hardianty Harun, Christian Marco Hadi Nugroho, Desak Gede Budi Krisnamurti, Okti Nadia Poetri, Agustin Indrawati, Simson Tarigan, Ketut Karuni Nyanakumari Natih, Fera Ibrahim, Pratiwi Pudjilestari Sudarmono8, Otto Sahat Martua Silaen   +11 more
doaj   +1 more source

Screening and purification of NanB sialidase from Pasteurella multocida with activity in hydrolyzing sialic acid Neu5Acα(2–6)Gal and Neu5Acα(2–3)Gal

Scientific Reports, 2022
Study on sialidases as antiviral agents has been widely performed, but many types of sialidase have not been tested for their antiviral activity. Pasteurella multocida NanB sialidase is one such sialidase that has never been isolated for further research.
Christian Marco Hadi Nugroho, Ryan Septa Kurnia, Simson Tarigan, Otto Sahat Martua Silaen, Silvia Triwidyaningtyas, I. Wayan Teguh Wibawan, Lily Natalia, Andi Khomeini Takdir, Amin Soebandrio   +8 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Development of mumps virus-specific sialidase imaging probes through chemical modifications of sialic acid. [PDF]

Sci Rep
Some viruses, such as mumps virus (MuV), possess sialidases that cleave terminal sialic acids, primarily N-acetylneuraminic acid (Neu5Ac), from glycans.
Narimichi Y, Takahashi T, Kurebayashi Y, Otsubo T, Ikeda K, Saito Y, Minami A, Takeuchi H.   +7 more
europepmc   +2 more sources