Results 11 to 20 of about 20,212 (212)
Design of Trypanosoma rangeli sialidase mutants with improved trans-sialidase activity. [PDF]
PLoS ONE, 2017 A sialidase (EC 3.2.1.18) from the non-pathogenic Trypanosoma rangeli, TrSA, has been shown to exert trans-sialidase activity after mutation of five specific amino acids in the active site (M96V, A98P, S120Y, G249Y, Q284P) to form the so-called TrSA5mut ...
Christian Nyffenegger +4 more
doaj +5 more sources
The Function of Sialidase Revealed by Sialidase Activity Imaging Probe [PDF]
International Journal of Molecular Sciences, 2021 Sialidase cleaves sialic acid residues from glycans such as glycoproteins and glycolipids. In the brain, desorption of the sialic acid by sialidase is essential for synaptic plasticity, learning and memory and synaptic transmission. BTP3-Neu5Ac has been developed for sensitive imaging of sialidase enzyme activity in mammalian tissues.
Minami, Akira +5 more
openaire +3 more sources
NEU3 (sialidase 3 (membrane sialidase)) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on NEU3 (sialidase 3 (membrane sialidase)), with data on DNA, on the protein encoded, and where the gene is implicated.
Yamaguchi, K, Miyagi, T
openaire +4 more sources
Genetic and functional characterization of the NanA sialidase from
Veterinary Research, 2011 Clostridium chauvoei is the causative agent of blackleg, a wide spread serious infection of cattle and sheep with high mortality. In this study we have analyzed the sialidase activity of the NanA protein of C. chauvoei and cloned the sialidase gene nanA.
Vilei Edy M +4 more
doaj +2 more sources
mBio, 2017 Neuraminidases (NAs) are critical virulence factors for several microbial pathogens. With a highly conserved catalytic domain, a microbial NA “superfamily” has been proposed.
Chiguang Feng +8 more
doaj +2 more sources
Plasmodium falciparum lacks sialidase and trans-sialidase activity
Parasitology, 1996 SUMMARYSialic acid on the red cell surface plays a major role in invasion by the malaria parasite Plasmodium falciparum. The NeuAc(α2,3) Gal motif on the O-linked tetrasaccharides of the red cell glycophorins is a recognition site for the parasite erythrocyte-binding antigen (EBA-175). Consequently, the interaction of P.
B, Clough +6 more
openaire +3 more sources
Trans‐sialidase and Sialidase Activities Discriminate between Morphologically Indistinguishable Trypanosomatids [PDF]
European Journal of Biochemistry, 1994 The expression of trans‐sialidase and sialidase activities in the kinetoplastid protozoa was explored as a potential marker to discriminate between the morphologically indistinguishable flagellates isolated from human, insects and vertebrate reservoir hosts. By virtue of the differences observed in the ratios of these enzyme activities, a collection of
Medina-acosta, E. +7 more
core +4 more sources
Novel sialic acid derivatives lock open the 150-loop of an influenza A virus group-1 sialidase [PDF]
, 2012 This work was supported by the Medical Research Council and the Scottish Funding Council.Influenza virus sialidase has an essential role in the virus’ life cycle.
Russell, Rupert James Martin +9 more
core +2 more sources
The role of the host—Neutrophil biology
Periodontology 2000, EarlyView., 2023 Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple +4 more
wiley +1 more source
Neu3 sialidase-mediated ganglioside conversion is necessary for axon regeneration and is blocked in CNS axons [PDF]
, 2014 This work was supported by the Medical Research Council, the Christopher and Dana Reeve Foundation, the John and Lucille van Geest Foundation, the Henry Smith Charity, the Commonwealth and Overseas scholarships, and the Hinduja Cambridge Trust.PNS axons ...
Cheah, Menghon +7 more
core +1 more source