Results 51 to 60 of about 2,977 (189)

Profiling cell surface sialoglycoproteins via the bio-orthogonal chemical reporter strategy combined with quantitative shotgun proteomics.

, 2014
The strategy consists of six steps: 1) metabolic labeling of cells with Ac4ManNAz; 2) chemoselective conjugation of azide-labeled glycans with a biotin-linked phosphine; 3) cell lysis; 4) affinity enrichment of the biotin-tagged proteins on streptavidin ...
Steven A. Goldman (652727), Michael Smith (26855), Pascual Ferrara (479981), Denis Loyaux (479980), Philippe Fabre (652723), Sébastien Roudières (652720), Romane Auvergne (652725), Jean-Claude Guillemot (479982), Catherine Déon (652721), Vasudeo Badarinarayana (652726), Su Wang (191010), Paul August (652728), Sridaran Natesan (245186), Frédérique Guette (652722), François Autelitano (652719), Qinggong Ping (652724)   +15 more
core   +1 more source

Beyond FimH: Diversity and Relevance of Carbohydrate‐Binding Fimbrial Proteins in Escherichia coli

ChemBioChem, Volume 26, Issue 17, September 15, 2025.
This review discusses fimbrial lectins found in Escherichia coli (E. coli) other than FimH, which could be targeted to treat E. coli pathogenicity as an alternative to antibiotic treatment. Escherichia coli (E. coli) is responsible for multiple diseases in humans and animals.
Oliwier R. Dulawa, Shane M. Coyle, Fiona Walsh, Trinidad Velasco‐Torrijos   +3 more
wiley   +1 more source

Antitumor Activities by a Humanized Cancer‐Specific Anti‐Podoplanin Monoclonal Antibody humPMab‐117 Against Human Tumors

Cancer Science, Volume 116, Issue 8, Page 2232-2242, August 2025.
A humanized cancer‐specific anti‐podoplanin monoclonal antibody humPMab‐117 exerts antibody‐dependent cellular cytotoxicity and complement‐dependent cytotoxicity against human tumor cells. In the xenograft tumor models, humPMab‐117 demonstrated strong antitumor efficacy.
Tomohiro Tanaka, Hiroyuki Suzuki, Tomokazu Ohishi, Manabu Kawada, Mika K. Kaneko, Yukinari Kato   +5 more
wiley   +1 more source

Erythrocyte glycophorins as receptors for Plasmodium merozoites

Parasites & Vectors, 2019
Glycophorins are heavily glycosylated sialoglycoproteins of human and animal erythrocytes. In humans, there are four glycophorins: A, B, C and D. Glycophorins play an important role in the invasion of red blood cells (RBCs) by malaria parasites, which ...
Ewa Jaskiewicz, Marlena Jodłowska, Radosław Kaczmarek, Agata Zerka   +3 more
doaj   +1 more source

Comparative Analysis of HMC3 and C20 Microglial Cell Lines Reveals Differential Myeloid Characteristics and Responses to Immune Stimuli

Immunology, Volume 175, Issue 1, Page 84-102, May 2025.
This study highlights comparative proteomic and morphological analyses of HMC3 and C20 microglial cell lines under baseline and inflammatory stimuli (LPS and IFN‐γ). Despite a 76.6% similarity in proteins, unstimulated HMC3 showed a transcriptional cell protein profile, whereas unstimulated C20 had a cell protein profile associated with the immune ...
Bavani Gunasegaran, Shivani Krishnamurthy, Sharron S. Chow, Millijoy D. Villanueva, Anna Guller, Seong Beom Ahn, Benjamin Heng   +6 more
wiley   +1 more source

9-O-Acetylated Sialoglycoproteins Are Important Immunomodulators in Indian Visceral Leishmaniasis [PDF]

, 2009
Overexpression of disease-associated 9-O-acetylated sialoglycoproteins (9-O-AcSGPs) on peripheral blood mononuclear cells (PBMC) of visceral leishmaniasis (VL) patients (PBMCVL) compared to their levels of expression in healthy individuals has been ...
Mukhopadhyay, Sumi, Chitra Mandal, Mandal, Chitra, Saha, Bibhuti, Ghoshal, Angana, Angana Ghoshal, Bibhuti Saha, Sumi Mukhopadhyay   +7 more
core   +1 more source

Neuraminidase 1 regulates neuropathogenesis by governing the cellular state of microglia via modulation of Trem2 sialylation

Cell Reports
Summary: Neuraminidase 1 (NEU1) cleaves terminal sialic acids from sialoglycoproteins in endolysosomes and at the plasma membrane. As such, NEU1 regulates immune cells, primarily those of the monocytic lineage.
Leigh Ellen Fremuth, Huimin Hu, Diantha van de Vlekkert, Ida Annunziata, Jason Andrew Weesner, Alessandra d’Azzo   +5 more
doaj   +1 more source

The Role of Sialic Acid-Binding Receptors (Siglecs) in the Immunomodulatory Effects of Trypanosoma cruzi Sialoglycoproteins on the Protective Immunity of the Host

Scientifica, 2013
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and is an important endemic infection in Latin America. Lately, it has also become a health concern in the United States and Europe.
Alexandre Morrot
doaj   +1 more source

E‐selectin affinity glycoproteomics reveals neuroendocrine proteins and the secretin receptor as a poor‐prognosis signature in colorectal cancer

Molecular Oncology, Volume 19, Issue 3, Page 635-658, March 2025.
Screening colorectal tumors for glycoproteins linked to disease progression has revealed several potential therapeutic targets. The secretin receptor (SCTR), identified as a marker of poor prognosis and metastasis in colorectal cancer, has been shown to be a key carrier of N‐glycans with sialylated Lewis antigens. These cancer‐specific glycoproteoforms
Sofia Cotton, Dylan Ferreira, Marta Relvas‐Santos, Andreia Brandão, Luís Pedro Afonso, Andreia Miranda, Eduardo Ferreira, Beatriz Santos, Martina Gonçalves, Paula Lopes, Lúcio Lara Santos, André M. N. Silva, José Alexandre Ferreira   +12 more
wiley   +1 more source

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

PLoS ONE, 2009
BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz, Vered Padler-Karavani, Darius Ghaderi, Nancy Hurtado-Ziola, Hai Yu, Xi Chen, Els C M Brinkman-Van der Linden, Ajit Varki, Nissi M Varki   +8 more
doaj   +1 more source