Results 71 to 80 of about 2,700 (196)

Sensitive and specific detection of the non-human sialic Acid N-glycolylneuraminic acid in human tissues and biotherapeutic products.

PLoS ONE, 2009
BackgroundHumans are genetically defective in synthesizing the common mammalian sialic acid N-glycolylneuraminic acid (Neu5Gc), but can metabolically incorporate it from dietary sources (particularly red meat and milk) into glycoproteins and glycolipids ...
Sandra L Diaz, Vered Padler-Karavani, Darius Ghaderi, Nancy Hurtado-Ziola, Hai Yu, Xi Chen, Els C M Brinkman-Van der Linden, Ajit Varki, Nissi M Varki   +8 more
doaj   +1 more source

Overcoming the Blood–Brain Barrier: Multifunctional Nanomaterial‐Based Strategies for Targeted Drug Delivery in Neurological Disorders

Small Science, Volume 4, Issue 12, December 2024.
This review explores the diverse range of nanomaterials, including polymer, lipid, gold, magnetic, and carbon‐based nanostructures, capable of effectively passing the blood–brain barrier (BBB). Moreover, the structure and function of the BBB in both healthy and diseased states are discussed and the potential of nanotechnology in bypassing the BBB to ...
Callan D. McLoughlin, Sarah Nevins, Joshua B. Stein, Mehrdad Khakbiz, Ki‐Bum Lee   +4 more
wiley   +1 more source

Flow-cytometric monitoring of disease-associated expression of 9-O-acetylated sialoglycoproteins in combination with known CD antigens, as an index for MRD in children with acute lymphoblastic leukaemia: a two-year longitudinal follow-up study

BMC Cancer, 2008
Background Over expression of 9-O-acetylated sialoglycoproteins (Neu5,9Ac2-GPs, abbreviated as OAcSGP) has been demonstrated as a disease-associated antigen on the lymphoblasts of childhood acute lymphoblastic leukaemia (ALL).
Chandra Sarmila, Mandal Chandan, Bandyopadhyay Suman, Chowdhury Suchandra, Mandal Chitra   +4 more
doaj   +1 more source

Siglec‐7 and Siglec‐9 expression in primary triple negative and oestrogen receptor positive breast cancer and in vitro signalling

Clinical &Translational Immunology, Volume 13, Issue 9, September 2024.
In this study, we found high Siglec‐7 and Siglec‐9 (ligand) expression in triple negative breast cancer, and to a lower extent in oestrogen receptor positive breast cancer. Moreover, signalling experiments demonstrated that Siglec‐7 signalling is induced by triple negative breast cancer cell lines.
Eline JH van Houtum, Anne HC Valk, Daniel Granado, Jasper Lok, Lune van den Bogaard, Naomi Remkes, Jesper van Eck van der Sluijs, Paul N Span, Lenneke AM Cornelissen, Gosse J Adema   +9 more
wiley   +1 more source

CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics, ionic microenvironments, ion fluxes, neuronal activation, and network neurotransductive capacity

Journal of Neuroscience Research, Volume 102, Issue 7, July 2024.
Proteoglycans are important multifunctional components of the central and peripheral nervous systems and represent a diverse group of specialized proteins that stabilize and functionalize these tissues. Abstract Central and peripheral nervous system (CNS/PNS) proteoglycans (PGs) have diverse functional roles, this study examined how these control ...
James Melrose
wiley   +1 more source

α-N-Acetylglucosamine-Linked O-Glycans of Sialoglycoproteins (Tc-Mucins) From Trypanosoma Cruzi Colombiana Strain [PDF]

, 2009
Trypanosoma cruzi sialoglycoproteins (Tc-mucins) are mucin-like molecules linked to a parasite membrane via a glycosylphosphatidylinositol anchor. We previously determined the structures of Tc-mucin O-glycan domains from several T.
Previato, José O., de Almeida, Eliane G., Todeschini, Adriane R., Mendonça-Previato, Lucia, Agrellos, Orlando A., Jones, Christopher   +5 more
core   +1 more source

OMIP‐102: 50‐color phenotyping of the human immune system with in‐depth assessment of T cells and dendritic cells

Cytometry Part A, Volume 105, Issue 6, Page 430-436, June 2024.
Abstract We report the development of an optimized 50‐color spectral flow cytometry panel designed for the in‐depth analysis of the immune system in human blood and tissues, with the goal of maximizing the amount of information that can be collected using currently available flow cytometry platforms.
Andrew J. Konecny, Peter L. Mage, Aaron J. Tyznik, Martin Prlic, Florian Mair   +4 more
wiley   +1 more source

O-Acetylation of GD3 Prevents its Apoptotic Effect and Promotes Survival of Lymphoblasts in Childhood Acute Lymphoblastic Leukaemia [PDF]

, 2008
We have previously demonstrated induction ofO-acetylated sialoglycoproteins on lymphoblasts of childhood acute lymphoblastic leukaemia (ALL). These molecules promote survival of lymphoblasts by preventing apoptosis.
Dey, Sailendra Nath, Kniep, Bernhard, Chandra, Sarmila, Mukherjee, Kankana, Chava, Anil Kumar, Mandal, Chitra, Mandal, Chandan   +6 more
core   +1 more source

Sialoglycoproteins and sialyltransferases: Key regulators of blastocyst formation

Cells & Development
Following fertilization, there is an initial period of rapid cell division that leads to the formation of a multicellular structure known as the blastula, or blastocyst. Within this structure, sialic acids play a key role in influencing cellular processes such as signaling, cell-to-cell contact, and adhesion.
Douchez, Pélagie, Fliniaux, Ingrid, Takeda-Uchimura, Yoshiko, Marin, Matthieu, Martoriati, Alain, Harduin-Lepers, Anne, Cailliau, Katia   +6 more
openaire   +3 more sources

Hyaluronan and chondroitin sulfate in chicken–vegetable bone broth delay osteoporosis progression

Journal of Food Science, Volume 89, Issue 3, Page 1791-1803, March 2024.
Abstract Bone broth has recently gained worldwide recognition as a superfood that supplements several nutrients lacking in modern human diets; however, little is known of its efficacy on osteoporosis. Therefore, we aimed to identify the components of chicken–vegetable bone broth (CVBB) that are associated with osteoporosis prevention and verified the ...
Yuka Seki, Risako Chiba Ohkuma, Yuri Miyakawa, Takeo Karakida, Ryuji Yamamoto, Yasuo Yamakoshi   +5 more
wiley   +1 more source