Results 71 to 80 of about 4,367 (168)

CDG due to Defective Membrane Transporters: Update

Journal of Inherited Metabolic Disease, Volume 49, Issue 1, January 2026.
ABSTRACT Congenital disorders of glycosylation are genetic defects in the glycoprotein and glycolipid glycan assembly and attachment. Some 200 CDG have been reported since the first clinical description in 1980. Most CDG are enzymatic deficiencies, but 13 (6.5%) are defects in the ER, Golgi apparatus (GA), and plasma membrane transporters.
D. Quelhas, C. R. Ferreira, J. Jaeken
wiley   +1 more source

Inhibition of fucosylation in human invasive ductal carcinoma reduces E‐selectin ligand expression, cell proliferation, and ERK1/2 and p38 MAPK activation

Molecular Oncology, 2018
Breast cancer tissue overexpresses fucosylated glycans, such as sialyl‐Lewis X/A (sLeX/A), and α‐1,3/4‐fucosyltransferases (FUTs) in relation to increased disease progression and metastasis.
Mylène A. Carrascal, Mariana Silva, José S. Ramalho, Cláudia Pen, Manuela Martins, Carlota Pascoal, Constança Amaral, Isabel Serrano, Maria José Oliveira, Robert Sackstein, Paula A. Videira   +10 more
doaj   +1 more source

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma

Scientific Reports
Alterations in protein glycosylation are observed in many solid tumor types leading to formation of tumor-associated carbohydrate antigens (TACAs). The most common TACA is the Tn antigen (CD175), which is a mucin-type O-GalNAc-Ser/Thr/Tyr glycan in ...
Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings   +7 more
doaj   +1 more source

The Sialyl Lewis X Glycan Receptor Facilitates Infection of Subtype H7 Avian Influenza A Viruses. [PDF]

J Virol, 2022
Guan M, Olivier AK, Lu X, Epperson W, Zhang X, Zhong L, Waters K, Mamaliger N, Li L, Wen F, Tao YJ, DeLiberto TJ, Wan XF.   +12 more
europepmc   +1 more source

Therapeutic Effects of an Anti-sialyl Lewis X Antibody in a Murine Model of Allergic Asthma. [PDF]

Int J Mol Sci, 2021
Xiong W, Liu W, Nishida S, Komiyama D, Liu W, Hirakawa J, Kawashima H.   +6 more
europepmc   +1 more source

Helicobacter pylori adhesion to gastric epithelial cells is mediated by glycan receptors

Brazilian Journal of Medical and Biological Research, 2010
Helicobacter pylori adhesion to gastric epithelial cells constitutes a key step in the establishment of a successful infection of the gastric mucosa. The high representation of outer membrane proteins in the bacterial genome suggests the relevance of ...
A. Magalhães, C.A. Reis
doaj  

Fucosylation enhances CD34⁺ hematopoietic stem cell homing and longevity via E-selectin–mediated adhesion and signaling

BMC Cancer
Background Hematopoietic stem cell transplantation (HSCT) is a cornerstone treatment for blood disorders and hematological malignancies, although its efficacy is limited by inefficient stem cell homing to the bone marrow.
Asma S. Al-Amoodi, Arwa A. Alghuneim, Jana S. Malki, Shuho Nozue, Yanyan Li, Jing Kai, Huoming Zhang, Dalila Bensaddek, Amal Kamal Abdel-Aziz, Satoshi Habuchi, Jasmeen S. Merzaban   +10 more
doaj   +1 more source

Enforced sialyl-Lewis-X (sLeX) display in E-selectin ligands by exofucosylation is dispensable for CD19-CAR T-cell activity and bone marrow homing. [PDF]

Clin Transl Med, 2021
Sánchez-Martínez D, Gutiérrez-Agüera F, Romecin P, Vinyoles M, Palomo M, Tirado N, Zanetti SR, Juan M, Carlet M, Jeremias I, Menéndez P.   +10 more
europepmc   +1 more source

The Sd^a Synthase B4GALNT2 Reduces Malignancy and Stemness in Colon Cancer Cell Lines Independently of Sialyl Lewis X Inhibition. [PDF]

Int J Mol Sci, 2020
Pucci M, Gomes Ferreira I, Malagolini N, Ferracin M, Dall'Olio F.   +4 more
europepmc   +1 more source

α1,3-fucosylation treatment improves cord blood CD34 negative hematopoietic stem cell navigation

iScience
Summary: For almost two decades, clinicians have overlooked the diagnostic potential of CD34neg hematopoietic stem cells because of their limited homing capacity relative to CD34posHSCs when injected intravenously.
Asma S. Al-Amoodi, Jing Kai, Yanyan Li, Jana S. Malki, Abdullah Alghamdi, Arwa Al-Ghuneim, Alfonso Saera-Vila, Satoshi Habuchi, Jasmeen S. Merzaban   +8 more
doaj   +1 more source