Results 51 to 60 of about 4,367 (168)

A Case of Anti‐AMY1‐Positive Lung Squamous Cell Carcinoma With Severe Hyperamylasemia Linked to Disease Progression

Respirology Case Reports, Volume 14, Issue 5, May 2026.
We present a case of anti‐AMY1‐positive lung squamous cell carcinoma (LUSC) with severe hyperamylasemia. To our knowledge, no previous cases of LUSC have been reported with both histological evidence of amylase production and hyperamylasemia. This case provides new evidence that LUSC can produce amylase and cause hyperamylasemia. ABSTRACT A 74‐year‐old
Yusuke Nakamura, Shohei Hara, Noriaki Nishimura, Yuto Goto, Nobuhiko Tsukada, Nana Yazawa, Yoshimasa Nakazato, Yokose Tomoyuki, Kazuyuki Ishida, Yasuo Shimizu, Seiji Niho   +10 more
wiley   +1 more source

Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression

BMC Cancer, 2007
Background Sialyl Lewis x (sLex) antigen is a carbohydrate antigen that is considered not only a marker for cancer but also implicated functionally in the malignant behaviour of cancer cells. Overexpression of sLex is associated with enhanced progression
Carvalheira Júlio, Marcos Nuno T, Lopes Célia, Matos Augusto JF, Pinho Salomé S, Reis Celso A, Gärtner Fátima   +6 more
doaj   +1 more source

The Critical Role of GALNTs‐Regulated O‐GalNAc Glycosylation in Cancer Malignancy

The FASEB Journal, Volume 40, Issue 8, 30 April 2026.
The GALNT family initiates mucin‐type O‐GalNAc glycosylation in the Golgi apparatus and how regulatory mechanisms, including GALNT relocalization and microRNA control, modulate this process. Dysregulated O‐GalNAc glycosylation alters key cellular behaviors and promotes cancer malignancy, highlighting its relevance to tumor progression as well as its ...
Jiahao Liu, Sihan Wu, Ge Zhang, Jiehan Li, Yuhan Yin, Aman Uiiah, Sanfei Peng, Yang Fu   +7 more
wiley   +1 more source

Invasive breast cancer in Argentine women: association between risk and prognostic factors with antigens of a peptidic and carbohydrate nature

Breast Cancer: Targets and Therapy, 2011
Sandra O Demichelis, Marina T Isla-Larrain, Luciano Cermignani, Cecilio G Alberdi, Amada Segal-Eiras, María Virginia CroceCentre of Basic and Applied Immunological Research, Faculty of Medical Sciences, National University of La Plata, La ...
Croce MV, Segal-Eiras A, Alberdi CG, Cermignani L, Isla-Larrain MT, Demichelis SO   +5 more
doaj  

Leukocyte Adhesion Deficiency in a 42‐Day‐Old Infant: A Case Report

Clinical Case Reports, Volume 14, Issue 4, April 2026.
ABSTRACT Leukocyte Adhesion Deficiency (LAD) is a rare primary immunodeficiency characterized by impaired leukocyte adhesion and migration, resulting in recurrent bacterial infections, poor wound healing, and delayed umbilical cord separation. We report a 42‐day‐old female infant who presented with recurrent skin infections and delayed cord detachment ...
Rasoul Goli, Nasrin Karimi, Ako Hassanzadeh, Somayeh Rezaei, Mansour Arad, Noushin Shahmirza, Reza Atharifar   +6 more
wiley   +1 more source

Alcohol induces α2‐6sialo mucin O‐glycans that kill U937 macrophages mediated by sialic acid‐binding immunoglobulin‐like lectin 7 (Siglec 7)

FEBS Open Bio
Alcohol misuse increases infections and cancer fatalities, but mechanisms underlying its toxicity are ill‐defined. We show that alcohol treatment of human tracheobronchial epithelial cells leads to inactivation of giantin‐mediated Golgi targeting of ...
Pi‐Wan Cheng, Vishwanath‐Reddy Hothpet, Ganapati Bhat, Kristina Bailey, Lei Li, Derrick R. Samuelson   +5 more
doaj   +1 more source

Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors.

PLoS Pathogens, 2017
Staphylococcus aureus is an opportunistic pathogen that produces many virulence factors. Two major families of which are the staphylococcal superantigens (SAgs) and the Staphylococcal Superantigen-Like (SSL) exoproteins.
Ries J Langley, Yi Tian Ting, Fiona Clow, Paul G Young, Fiona J Radcliff, Jeong Min Choi, Richard P Sequeira, Silva Holtfreter, Heather Baker, John D Fraser   +9 more
doaj   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source

Amyloid-β peptide on sialyl-Lewis(X)-selectin-mediated membrane tether mechanics at the cerebral endothelial cell surface. [PDF]

PLoS ONE, 2013
Increased deposition of amyloid-β peptide (Aβ) at the cerebral endothelial cell (CEC) surface has been implicated in enhancement of transmigration of monocytes across the brain blood barrier (BBB) in Alzheimer's disease (AD).
Sholpan Askarova, Zhe Sun, Grace Y Sun, Gerald A Meininger, James C-M Lee   +4 more
doaj   +1 more source

GlycoChat Uncovers Glycan–Lectin Circuits in the Tumor Microenvironment of Pancreatic Cancer

Advanced Science, Volume 13, Issue 14, 9 March 2026.
Aberrant glycosylation drives cancer progression, yet its role in the tumor microenvironment remains unclear. We developed GlycoChat to map glycan–lectin circuits at single‐cell resolution. We discovered that cancer cells induce immunosuppressive macrophage differentiation and impair phagocytosis through interactions with CLEC10A and SIGLEC3 ...
Dinh Xuan Tuan Anh, Sunanda Keisham, Arun Burramsetty, Lalhaba Oinam, Koichiro Kumano, Akihiro Kuno, Osamu Shimomura, Tatsuya Oda, Hiroaki Tateno   +8 more
wiley   +1 more source