Results 1 to 10 of about 48,220 (193)

Sialylated Lewis x Antigen Bearing Glycoproteins in Human Plasma [PDF]

Journal of Proteome Research, 2010
Recent studies have shown that antibodies targeting Lewis x (Le(x)) antigen are a valuable tool in the isolation and identification of glycoproteins in plasma. A focus of this study was to determine whether sialylated Lewis x (sLe(x)) antigen carrying glycoproteins occur in human plasma and whether an antibody targeting this antigen could be used to ...
Fred E Regnier
exaly   +5 more sources

Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages [PDF]

Frontiers in Immunology, 2021
BackgroundLewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are known to mediate adhesion between tumor cells and endothelium by interacting with its selectin ...
Zhi Ma, Huixia Yang, Lin Peng, Christina Kuhn, Anca Chelariu-Raicu, Sven Mahner, Udo Jeschke, Udo Jeschke, Viktoria von Schönfeldt   +8 more
doaj   +5 more sources

Expression of Lewisa, Sialyl Lewisa, Lewisx, Sialyl Lewisx, Antigens as Prognostic Factors in Patients with Colorectal Cancer [PDF]

Canadian Journal of Gastroenterology, 2000
BACKGROUND: Altered expression of blood group-related carbohydrate antigens such as sialyl Lewis (Le)x antigen in tumours is associated with tumour progression behaviour and subsequent prognosis.
Tohru Nakagoe, Kiyoyasu Fukushima, Atsushi Nanashima, Terumitsu Sawai, Takashi Tsuji, Masaaki Jibiki, Hiroyuki Yamaguchi, Toru Yasutake, Hiroyoshi Ayabe, Tatsuki Matuo, Yutaka Tagawa, Kokichi Arisawa   +11 more
doaj   +3 more sources

Schistosoma mansoni α1,3-fucosyltransferase-F generates the Lewis X antigen. [PDF]

Glycobiology, 2016
Genetic evidence suggests that the Schistosoma mansoni genome contains six genes that encode α1,3-fucosyltransferases (smFuTs). To date, the activities and specificities of these putative fucosyltransferases are unknown. As Schistosoma express a variety of fucosylated glycans, including the Lewis X antigen Galβ1-4(Fucα1-3)GlcNAcβ-R, it is likely that ...
Mickum ML, Rojsajjakul T, Yu Y, Cummings RD.   +3 more
europepmc   +3 more sources

Therapeutic targeting of cancer stem cell-specific surface glycans and glycoproteins [PDF]

Discover Oncology
Cancer stem cells (CSCs) represent a critical subpopulation within tumors, driving malignancy, metastasis, and therapeutic resistance. Their unique biological attributes, particularly the distinctive landscape of surface glycans and glycoproteins, offer ...
Mutaz Jamal Al-khreisat, Waleed K. Abdulsahib, Ihsan Khudhair Jasim, H. Malathi, Priya Priyadarshini Nayak, D. Alex Anand, Gunjan Mukherjee, Aashna Sinha, Gulsara Ruziyeva   +8 more
doaj   +2 more sources

Allergic Bronchopulmonary Aspergillosis With Elevated Serum Tumour Marker Levels [PDF]

Respirology Case Reports
We present the case of a 56‐year‐old woman diagnosed with allergic bronchopulmonary aspergillosis (ABPA) who showed multiple nodular shadows on a chest x‐ray.
Hiroaki Ishikawa, Mari Anzai, Ayaka Kishimoto, Tomohiro Namiki, Ryusei Nakagawa, Hiroya Sunabe, Toshihide Inui, Hiroko Watanabe, Yuichi Dai, Tohru Sakamoto   +9 more
doaj   +2 more sources

One‐Pot Multienzyme Synthesis of Lewis x and Sialyl Lewis x Antigens [PDF]

Current Protocols in Chemical Biology, 2012
AbstractL‐Fucose has been found abundantly in human milk oligosaccharides, bacterial lipopolysaccharides, glycolipids, and many N‐ and O‐linked glycans produced by mammalian cells. Fucose‐containing carbohydrates have important biological functions. Alterations in the expression of fucosylated oligosaccharides have been observed in several pathological
Hai, Yu, Kam, Lau, Yanhong, Li, Go, Sugiarto, Xi, Chen   +4 more
openaire   +2 more sources

Is there a link between the lipopolysaccharide of Helicobacter pylori gastric MALT lymphoma associated strains and lymphoma pathogenesis? [PDF]

PLoS ONE, 2009
The aim of this study was to investigate the Lewis antigen expression in Helicobacter pylori gastric MALT lymphoma associated strains in comparison to chronic gastritis only strains.
Philippe Lehours, Zongli Zheng, Anna Skoglund, Francis Mégraud, Lars Engstrand   +4 more
doaj   +1 more source

Structure of an Anti-Lewis X Fab Fragment in Complex with Its Lewis X Antigen [PDF]

Structure, 2004
The Lewis X trisaccharide is pivotal in mediating specific cell-cell interactions. Monoclonal antibody 291-2G3-A, which was generated from mice infected with schistosomes, has been shown to recognize the Lewis X trisaccharide. Here we describe the structure of the Fab fragment of 291-2G3-A, with Lewis X, to 1.8 A resolution.
Roon, A.M., Pannu, N.S., Vrind, J.P., Marel, G.A. van der, Boom, J.H. van, Hokke, C.H., Deelder, A.M., Abrahams, J.P.   +7 more
openaire   +4 more sources

alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo. [PDF]

PLoS ONE, 2010
BACKGROUND: Cell surface sialylation is emerging as an important feature of cancer cell metastasis. Sialyltransferase expression has been reported to be altered in tumours and may account for the formation of sialylated tumour antigens.
Marta Pérez-Garay, Beatriz Arteta, Lluís Pagès, Rafael de Llorens, Carme de Bolòs, Fernando Vidal-Vanaclocha, Rosa Peracaula   +6 more
doaj   +1 more source