Results 31 to 40 of about 48,220 (193)

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma

Diagnostic Pathology, 2011
Background To elucidate relations of invasion of ulcerative colitis (UC)-associated carcinoma with its prognosis, the characteristics of invasive fronts were analyzed in comparison with sporadic colonic carcinomas.
Araki Kayo, Kikuchi Masaomi, Numata Yoshiko, Yoshida Tsutomu, Mikami Tetuo, Nakada Norihiro, Okayasu Isao   +6 more
doaj   +1 more source

Systematic chemoenzymatic synthesis of O-sulfated sialyl Lewis x antigens

Chemical Science, 2016
O-Sulfated sialyl Lewisxantigens containing different sialic acid forms were chemoenzymatically synthesized using a bacterial sialyltransferase mutant.
Santra, Abhishek, Yu, Hai, Tasnima, Nova, Muthana, Musleh M, Li, Yanhong, Zeng, Jie, Kenyon, Nicholas J, Louie, Angelique Y, Chen, Xi   +8 more
openaire   +5 more sources

3‐Deoxy‐3‐Fluoro Mannuronic Acid Alginates: Stereoselective Automated Synthesis and Conformational Behaviour

Angewandte Chemie, EarlyView.
The impact of C‐3 fluorination on the synthesis and conformation of alginate oligosaccharides is investigated. A C‐3‐fluoro mannuronic acid building block is generated and shown to react with high β‐selectivity. Automated glycan assembly enables access to uniquely fluorinated mannuronic acid alginates where deoxyfluorination is shown not to perturb the
Sean T. Evans, Nishu Yadav, Wouter A. Remmerswaal, Daan Hoogers, Koen N. A. van de Vrande, Sarah Hosking, Ana Poveda, Jeroen D. C. Codée, Jesús Jiménez‐Barbero, Martina Delbianco, Gavin J. Miller   +10 more
wiley   +2 more sources

Newly established monoclonal antibody diagnostic assays for Schistosoma mansoni direct detection in areas of low endemicity. [PDF]

PLoS ONE, 2014
Current available methods for diagnosis of schistosomiasis mansoni lack sufficient sensitivity, which results in underreporting of infectious in areas of low endemicity.We developed three novel diagnostic methodologies for the direct detection of ...
Rafaella Fortini Queiroz Grenfell, Paulo Marcos Zech Coelho, Diana Taboada, Ana Carolina Alves de Mattos, Ruth Davis, Donald A Harn   +5 more
doaj   +1 more source

Expression of Lewis[x], sialylated Lewis[x], Lewis[a], and sialylated Lewis[a] antigens in human lung carcinoma

The Tohoku Journal of Experimental Medicine, 1991
One hundred and five cases of various human lung neoplasms were studied immunohistochemically using monoclonal antibodies recognizing the antigens, Le(x), sialylated Le(x) (SLEX), Le(a), and sialylated Le(a) (SLEA). Of the 92 lung cancers examined for antigen expression SLEX was detected in 57% (52 cases), Le(x) in 42% (39), SLEA in 36% (33), and Le(a)
openaire   +4 more sources

Clinicopathological significance of core 3 O-glycan synthetic enzyme, β1,3-N-acetylglucosaminyltransferase 6 in pancreatic ductal adenocarcinoma.

PLoS ONE, 2020
Mucin-type O-glycans are involved in cancer initiation and progression, although details of their biological and clinicopathological roles remain unclear.
Noriteru Doi, Yoshinori Ino, Kiyohiko Angata, Kazuaki Shimada, Hisashi Narimatsu, Nobuyoshi Hiraoka   +5 more
doaj   +1 more source

Changes in surface glycosylation and glycocalyx shedding in Trichobilharzia regenti (Schistosomatidae) during the transformation of cercaria to schistosomulum. [PDF]

PLoS ONE, 2017
The invasive larvae (cercariae) of schistosomes penetrate the skin of their definitive hosts. During the invasion, they undergo dramatic ultrastructural and physiological transitions.
Jana Řimnáčová, Libor Mikeš, Libuše Turjanicová, Jana Bulantová, Petr Horák   +4 more
doaj   +1 more source

Chelator‐Free Radiometal Labeling Inside Engineered Affibodies

Angewandte Chemie, EarlyView.
Affibodies are compact and robust three‑helix binders used in imaging and therapy. Engineering a triple‑cysteine motif into their core enables chelator‑free binding of important radiometals, like Bi(III), Pb(II), In(III), and Ga(III) with rapid uptake and exceptional stability.
Lani J. Davies, Upamali Somathilake, Santhanalaxmi Kumaresan, Frank Bruchertseifer, Alfred Morgenstern, Sarah Spreckelmeyer, Christoph Nitsche   +6 more
wiley   +2 more sources

The Diagnostic Value of Various Immunohistochemical Biomarkers in the Detection of Papillary and Follicular Thyroid Cancers: A Systematic Review and Metaanalysis [PDF]

Journal of Health Sciences and Surveillance System
Background: Thyroid neoplasia is the most common endocrine malignancy worldwide. Fine-needle aspiration biopsy of thyroid nodules has a low sensitivity in distinguishing between benign and malignant lesions.
Mitra Heirdarpour, Yalda Heshmati, Alireza Rahimi, Awat Feizi, Reza Rakhshan, Maryam Ghasemi   +5 more
doaj   +1 more source