Results 21 to 30 of about 48,220 (193)

Recognition of Dimeric Lewis X by Anti-Dimeric Le^x Antibody SH2

Vaccines, 2020
The carbohydrate antigen dimeric Lewis X (DimLex), which accumulates in colonic and liver adenocarcinomas, is a valuable target to develop anti-cancer therapeutics.
Sinthuja Jegatheeswaran, Ari Asnani, Adam Forman, Jenifer L. Hendel, Christopher J. Moore, Ali Nejatie, An Wang, Jo-Wen Wang, France-Isabelle Auzanneau   +8 more
doaj   +1 more source

Directional homing of glycosylation-modified bone marrow mesenchymal stem cells for bone defect repair

Journal of Nanobiotechnology, 2021
Background One of the greatest challenges for tissue-engineered bone is the low survival rate of locally grafted cells. The cell homing technology can effectively increase the number of these grafted cells, therefore, enhancing the repair of bone defects.
Long Chen, Wei Luo, Yuanzheng Wang, Xiongbo Song, Senlei Li, Jun Wu, Li Sun   +6 more
doaj   +1 more source

Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.

PLoS ONE, 2013
Sialyl-Lewis X (SLe(x)) is a sialylated glycan antigen expressed on the cell surface during malignant cell transformation and is associated with cancer progression and poor prognosis.
Catarina Gomes, Hugo Osório, Marta Teixeira Pinto, Diana Campos, Maria José Oliveira, Celso A Reis   +5 more
doaj   +1 more source

Helicobacter pylori lipopolysaccharide modification, Lewis antigen expression, and gastric colonization are cholesterol-dependent

BMC Microbiology, 2009
Background Helicobacter pylori specifically takes up cholesterol and incorporates it into the bacterial membrane, yet little is currently known about cholesterol's physiological roles. We compared phenotypes and in vivo colonization ability of H.
McGee David J, Hildebrandt Ellen
doaj   +1 more source

Glycans Related to the CA19-9 Antigen Are Increased in Distinct Subsets of Pancreatic Cancers and Improve Diagnostic Accuracy Over CA19-9Summary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: The cancer antigen 19-9 (CA19-9) is the current best biomarker for pancreatic cancer, but it is not increased in approximately 25% of pancreatic cancer patients at a cut-off value that provides a 25% false-positive rate.
Huiyuan Tang, Katie Partyka, Peter Hsueh, Jessica Y. Sinha, Doron Kletter, Herbert Zeh, Ying Huang, Randall E. Brand, Brian B. Haab   +8 more
doaj   +1 more source

Diagnosis of Bladder Cancer with Urinary Cytology, Immunocytology and DNA-Image-Cytometry1

Analytical Cellular Pathology, 2001
DNA‐image‐cytometry and antibodies directed against the Lewis X‐ and the 486p 3/12 antigen were applied to improve diagnostic accuracy of urinary cytology for the detection of bladder cancer.
Bernhard Planz, Christian Synek, Thomas Deix, Alfred Böcking, Michael Marberger   +4 more
doaj   +1 more source

Adhesion of Helicobacter Species to the Human Gastric Mucosa: A Deep Look Into Glycans Role

Frontiers in Molecular Biosciences, 2021
Helicobacter species infections may be associated with the development of gastric disorders, such as gastritis, peptic ulcers, intestinal metaplasia, dysplasia and gastric carcinoma.
Rita Matos, Rita Matos, Rita Matos, Irina Amorim, Irina Amorim, Irina Amorim, Ana Magalhães, Ana Magalhães, Freddy Haesebrouck, Fátima Gärtner, Fátima Gärtner, Celso A. Reis, Celso A. Reis, Celso A. Reis, Celso A. Reis   +14 more
doaj   +1 more source

Comparative immunological studies of tumor-associated Lewis X, Lewis Y, and KH-1 antigens

Carbohydrate Research, 2020
Tumor-associated carbohydrate antigens Lewis X (Lex), Lewis Y (Ley), and KH-1 are useful targets for cancer immunotherapy. In this regard, an insight into the structure-immunogenicity relationships of these antigens is important but this has not been systematically investigated yet.
Jiatong, Guo, Wenjie, Jiang, Qingjiang, Li, Mohit, Jaiswal, Zhongwu, Guo   +4 more
openaire   +3 more sources

Losses of expression of the antigens A, Le^a and Le^x and over-expression of Le^y in carcinomas and HG-SIL of the uterine cervix

Diagnostic Pathology, 2008
Background The glycosylation of a great number of molecules, glyco-protein or glycolipids, has been of interest for decades. Objective To compare the expressive patterns of the isoantigenic determinants of histo-blood groups ABH and Lewis in squamous and
Álvarez-Fernández Emilio, Moro-Rodríguez Ernesto   +1 more
doaj   +1 more source

Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow. [PDF]

PLoS ONE, 2013
Hematogenous metastasis accounts for the majority of cancer-related deaths, yet the mechanism remains unclear. Circulating tumor cells (CTCs) in blood may employ different pathways to cross blood endothelial barrier and establish a metastatic niche ...
Gunjan Gakhar, Vicente N Navarro, Madelyn Jurish, Guang Yu Lee, Scott T Tagawa, Naveed H Akhtar, Marco Seandel, Yue Geng, He Liu, Neil H Bander, Paraskevi Giannakakou, Paul J Christos, Michael R King, David M Nanus   +13 more
doaj   +1 more source