Results 31 to 40 of about 4,367 (168)
Synthesis of Sialyl Lewis X-Polysaccharide Conjugates.
Chemical and Pharmaceutical Bulletin, 2000 Sialyl Lewis X (SLeX) is well known as a ligand of the cell adhesion molecule E-selectin which is specifically expressed at inflammatory lesion sites. We have synthesized several SLeX-polysaccharide conjugates and examined their potential for drug delivery to inflammatory lesions.
SAKAGAMI, Masahiro +4 more
openaire +3 more sources
A Knowledge-Based System for Display and Prediction of O-Glycosylation Network Behaviour in Response to Enzyme Knockouts. [PDF]
PLoS Computational Biology, 2016 O-linked glycosylation is an important post-translational modification of mucin-type protein, changes to which are important biomarkers of cancer. For this study of the enzymes of O-glycosylation, we developed a shorthand notation for representing GalNAc-
Andrew G McDonald +2 more
doaj +1 more source
Characterization of bovine
BMC Genetics, 2012 Background The Sialyl-Lewis X (Slex) is a well-known glycan structure involved in leukocyte homing and recruitment to inflammatory sites. SLex is well conserved among species and is mainly synthesized by FucT-VII in vertebrates.
Laporte Benoît +6 more
doaj +1 more source
Cell Transplantation, 2020 Adult-derived human liver stem/progenitor cells (ADHLSCs) are a promising alternative to orthotopic liver transplantation in the treatment of inborn errors of metabolism.
Pierre Edouard Dollet +9 more
doaj +1 more source
Cellular and Molecular Gastroenterology and Hepatology, 2016 Background & Aims: The cancer antigen 19-9 (CA19-9) is the current best biomarker for pancreatic cancer, but it is not increased in approximately 25% of pancreatic cancer patients at a cut-off value that provides a 25% false-positive rate.
Huiyuan Tang +8 more
doaj +1 more source
The Tohoku Journal of Experimental Medicine, 1991 One hundred and five cases of various human lung neoplasms were studied immunohistochemically using monoclonal antibodies recognizing the antigens, Le(x), sialylated Le(x) (SLEX), Le(a), and sialylated Le(a) (SLEA). Of the 92 lung cancers examined for antigen expression SLEX was detected in 57% (52 cases), Le(x) in 42% (39), SLEA in 36% (33), and Le(a)
openaire +4 more sources
A Structural-Reporter Group to Determine the Core Conformation of Sialyl Lewisx Mimetics
Molecules, 2023 The d-GlcNAc moiety in sialyl Lewisx (sLex, 1) acts predominantly as a linker to position the d-Gal and the l-Fuc moieties in the bioactive spatial orientation.
Beatrice Wagner +8 more
doaj +1 more source
Food Frontiers, Volume 7, Issue 4, July 2026.Apple pomace pectin is explored as a sustainable and multifunctional biomaterial for gastric ulcer management. Its unique structural features confer mucoadhesive, anti‐inflammatory, antioxidant, and anti‐Helicobacter pylori activities while enabling nano/microencapsulation of therapeutic agents.
Akash Dhiman +6 more
wiley +1 more source
BMC Cancer, 2022 Background Routine measurement of tumor markers is not recommended in daily clinical practice for patients with cancer of unknown primary (CUP). We evaluated the diagnostic value of tumor markers in identifying favorable or unfavorable subsets in ...
Shigemasa Takamizawa +14 more
doaj +1 more source
Reprogramming the Immune Landscape of Inflammatory Breast Cancer
Advanced Science, Volume 13, Issue 36, 29 June 2026.Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez +3 more
wiley +1 more source