Results 41 to 50 of about 4,367 (168)

Cell‐specific targeting of extracellular vesicles through engineering the glycocalyx

Journal of Extracellular Vesicles, 2022
Extracellular vesicles (EVs) are promising carriers for the delivery of a variety of chemical and biological drugs. However, their efficacy is limited by the lack of cellular specificity.
Wenyi Zheng, Rui He, Xiuming Liang, Samantha Roudi, Jeremy Bost, Pierre‐Michael Coly, Guillaume vanNiel, Samir E. L. Andaloussi   +7 more
doaj   +1 more source

Surface N‐Glycosylation Dictates MSC‐EV Uptake and CCR2‐Driven Monocyte Recruitment to Inflamed Endothelium Under Shear Flow

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Mesenchymal stromal cell‐derived extracellular vesicles (MSC‐EV) hold promising potential for immunomodulation and tissue regeneration, especially for treating ischemia‐reperfusion injury (IRI). However, their therapeutic use is hindered by challenges in tissue targeting and incomplete understanding of their functional mechanisms.
Marta Clos‐Sansalvador, Marta Monguió‐Tortajada, Sergio G. Garcia, Manuel Pérez‐Martínez, Marta Sanroque‐Muñoz, Miriam Font‐Morón, Diego Megías, Isabel Peset, Marcella Franquesa, Marta Hergueta‐Redondo, Hector Peinado, Francesc E. Borràs   +11 more
wiley   +1 more source

Combining radiotherapy with CAR‐T cell therapy for solid tumors: Challenges, mechanisms, and future directions

Precision Radiation Oncology, Volume 10, Issue 2, Page 192-204, June 2026.
Radiotherapy enhances CAR‐Tcell therapy by increasing antigenicity, improving trafficking, and reshaping the tumor microenvironment. Despite its dual effects, including potential immune suppression, understanding these mechanisms enables the development of strategies to maximize synergy in solid tumors.
Leran Qiu, Xingyu Zhou, Jiao Xue, Xiaokang Zhang, Songbing Qin   +4 more
wiley   +1 more source

Increasing evidence of the role of Helicobacter pylori SabA in the pathogenesis of gastroduodenal disease

Journal of Infection in Developing Countries, 2008
Although infection with Helicobacter pylori always results in chronic active gastritis, only a fraction of those infected develop severe clinical disease. In addition, certain populations with high incidences of H. pylori infection, such as those in East
Yoshio Yamaoka
doaj   +3 more sources

Selectins—The Two Dr. Jekyll and Mr. Hyde Faces of Adhesion Molecules—A Review

Molecules, 2020
Selectins belong to a group of adhesion molecules that fulfill an essential role in immune and inflammatory responses and tissue healing. Selectins are glycoproteins that decode the information carried by glycan structures, and non-covalent interactions ...
Igor Tvaroška, Chandrabose Selvaraj, Jaroslav Koča   +2 more
doaj   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

The Diagnostic Value of Various Immunohistochemical Biomarkers in the Detection of Papillary and Follicular Thyroid Cancers: A Systematic Review and Metaanalysis [PDF]

Journal of Health Sciences and Surveillance System
Background: Thyroid neoplasia is the most common endocrine malignancy worldwide. Fine-needle aspiration biopsy of thyroid nodules has a low sensitivity in distinguishing between benign and malignant lesions.
Mitra Heirdarpour, Yalda Heshmati, Alireza Rahimi, Awat Feizi, Reza Rakhshan, Maryam Ghasemi   +5 more
doaj   +1 more source

Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site

European Journal of Immunology, Volume 56, Issue 5, May 2026.
This study shows that loss of sialylation in CT26 cells reduces peritoneal tumor burden, correlating with a lower peritoneal cancer index score. These tumors exhibited increased immune infiltration with prominent alterations in the myeloid compartment and immune cell correlations unique to desialylated tumors, indicating profound reshaping of antitumor
Irene van der Haar Àvila, Kristiaan Lenos, Victor Lorrain, Eleonora Nardini, Ernesto Rodríguez, Juan J. García‐Vallejo, Yvette van Kooyk, Joep Grootjans, Sandra J. van Vliet   +8 more
wiley   +1 more source

Human Epidermal Keratinocyte Expression of Sialyl-Lewis X

Journal of Investigative Dermatology, 1992
Cell-surface oligosaccharides can function as ligands for intercellular adhesion receptors, matrix proteins, and growth factors. We report that human neonatal and adult epidermal keratinocytes (KC) express sialyl Lewis X [s-Le(x); SA alpha 2-3Gal beta 1-4(Fuc alpha 1-3)GlcNAc beta 1-3R], a ligand for endothelial and platelet selectins. Freshly isolated
Symington, Frank W, Holmes, Eric H, Symington, Banu E   +2 more
openaire   +2 more sources

Structural analysis of N-glycans in chicken trachea and lung reveals potential receptors of chicken influenza viruses

Scientific Reports, 2022
Although avian influenza A viruses (avian IAVs) bind preferentially to terminal sialic acids (Sia) on glycans that possess Siaα2-3Gal, the actual glycan structures found in chicken respiratory tracts have not been reported.
Noriko Suzuki, Tatsuya Abe, Shunji Natsuka   +2 more
doaj   +1 more source