Results 1 to 10 of about 7,548 (172)

Expression of the Carbohydrate Lewis Antigen, Sialyl Lewis A, Sialyl Lewis X, Lewis X, and Lewis Y in the Placental Villi of Patients With Unexplained Miscarriages [PDF]

Frontiers in Immunology, 2021
BackgroundLewis antigens such as Sialyl Lewis A (sLeA), Sialyl Lewis X (sLeX), Lewis X (LeX), and Lewis Y (LeY) are a class of carbohydrate molecules that are known to mediate adhesion between tumor cells and endothelium by interacting with its selectin ...
Zhi Ma, Huixia Yang, Lin Peng, Christina Kuhn, Anca Chelariu-Raicu, Sven Mahner, Udo Jeschke, Udo Jeschke, Viktoria von Schönfeldt   +8 more
doaj   +9 more sources

Expression of Lewisa, Sialyl Lewisa, Lewisx, Sialyl Lewisx, Antigens as Prognostic Factors in Patients with Colorectal Cancer [PDF]

Canadian Journal of Gastroenterology, 2000
BACKGROUND: Altered expression of blood group-related carbohydrate antigens such as sialyl Lewis (Le)x antigen in tumours is associated with tumour progression behaviour and subsequent prognosis.
Tohru Nakagoe, Kiyoyasu Fukushima, Atsushi Nanashima, Terumitsu Sawai, Takashi Tsuji, Masaaki Jibiki, Hiroyuki Yamaguchi, Toru Yasutake, Hiroyoshi Ayabe, Tatsuki Matuo, Yutaka Tagawa, Kokichi Arisawa   +11 more
doaj   +5 more sources

Selectin ligand sialyl-Lewis x antigen drives metastasis of hormone-dependent breast cancers. [PDF]

Cancer Res, 2011
Abstract The glycome acts as an essential interface between cells and the surrounding microenvironment. However, changes in glycosylation occur in nearly all breast cancers, which can alter this interaction. Here, we report that profiles of glycosylation vary between ER-positive and ER-negative breast cancers.
Julien S, Ivetic A, Grigoriadis A, QiZe D, Burford B, Sproviero D, Picco G, Gillett C, Papp SL, Schaffer L, Tutt A, Taylor-Papadimitriou J, Pinder SE, Burchell JM.   +13 more
europepmc   +6 more sources

Relation between recurrence and expression of proliferating cell nuclear antigen, sialyl Lewis X, and sialyl Lewis a in lung cancer [PDF]

Journal of Thoracic and Cardiovascular Surgery, 1994
Blood vessel invasion, recurrence rate, and time to recurrence were examined in relation to the immunohistochemical expression of proliferating cell nuclear antigen, sialyl LewisX, and sialyl Lewis(a) in 303 patients with lung cancer who had a curative resection from 1980 to 1991.
Jun-Ichi Ogawa, Akira Shohtsu
exaly   +4 more sources

One‐Pot Multienzyme Synthesis of Lewis x and Sialyl Lewis x Antigens [PDF]

Current Protocols in Chemical Biology, 2012
AbstractL‐Fucose has been found abundantly in human milk oligosaccharides, bacterial lipopolysaccharides, glycolipids, and many N‐ and O‐linked glycans produced by mammalian cells. Fucose‐containing carbohydrates have important biological functions. Alterations in the expression of fucosylated oligosaccharides have been observed in several pathological
Hai Yu, Kam Lau, Yanhong Li, Go Sugiarto, Xi Chen   +4 more
openalex   +4 more sources

Allergic Bronchopulmonary Aspergillosis With Elevated Serum Tumour Marker Levels [PDF]

Respirology Case Reports
We present the case of a 56‐year‐old woman diagnosed with allergic bronchopulmonary aspergillosis (ABPA) who showed multiple nodular shadows on a chest x‐ray.
Hiroaki Ishikawa, Mari Anzai, Ayaka Kishimoto, Tomohiro Namiki, Ryusei Nakagawa, Hiroya Sunabe, Toshihide Inui, Hiroko Watanabe, Yuichi Dai, Tohru Sakamoto   +9 more
doaj   +2 more sources

Therapeutic targeting of cancer stem cell-specific surface glycans and glycoproteins [PDF]

Discover Oncology
Cancer stem cells (CSCs) represent a critical subpopulation within tumors, driving malignancy, metastasis, and therapeutic resistance. Their unique biological attributes, particularly the distinctive landscape of surface glycans and glycoproteins, offer ...
Mutaz Jamal Al-khreisat, Waleed K. Abdulsahib, Ihsan Khudhair Jasim, H. Malathi, Priya Priyadarshini Nayak, D. Alex Anand, Gunjan Mukherjee, Aashna Sinha, Gulsara Ruziyeva   +8 more
doaj   +2 more sources

Biosynthesis and expression of the Sda and sialyl Lewis x antigens in normal and cancer colon [PDF]

Glycobiology, 2007
The carbohydrate determinants Sd(a) and sialyl Lewis x (sLex) both result from substitution of an alpha2,3-sialylated type 2 chain: the first with an N-acetylgalactosamine (GalNAc) beta1,4-linked to Gal and the second by an alpha1,3-linked fucose on N-acetylglucosamine. The Sd(a) antigen is synthesized by Sd(a) beta1,4-N-acetylgalactosaminyltransferase
Nadia Malagolini, Donatella Santini, Mariella Chiricolo   +2 more
exaly   +4 more sources

Differential expression of CD175 and CA19-9 in pancreatic adenocarcinoma [PDF]

Scientific Reports
Alterations in protein glycosylation are observed in many solid tumor types leading to formation of tumor-associated carbohydrate antigens (TACAs). The most common TACA is the Tn antigen (CD175), which is a mucin-type O-GalNAc-Ser/Thr/Tyr glycan in ...
Jane J. Cheng, Yasuyuki Matsumoto, Gabrielle E. Dombek, Kathryn A. Stackhouse, Ana Sofia Ore, Jonathan N. Glickman, Jamie Heimburg-Molinaro, Richard D. Cummings   +7 more
doaj   +2 more sources

Systematic chemoenzymatic synthesis of O-sulfated sialyl Lewis x antigens

Chemical Science, 2015
O-Sulfated sialyl Lewisxantigens containing different sialic acid forms were chemoenzymatically synthesized using a bacterial sialyltransferase mutant.
Abhishek Santra, Hai Yu, Nova Tasnima, Musleh M. Muthana, Yanhong Li, Jie Zeng, Nicholas J. Kenyon, Angelique Y. Louie, Xi Chen   +8 more
openalex   +6 more sources