Results 31 to 40 of about 7,429 (165)

Clinicopathological significance of core 3 O-glycan synthetic enzyme, β1,3-N-acetylglucosaminyltransferase 6 in pancreatic ductal adenocarcinoma.

PLoS ONE, 2020
Mucin-type O-glycans are involved in cancer initiation and progression, although details of their biological and clinicopathological roles remain unclear.
Noriteru Doi, Yoshinori Ino, Kiyohiko Angata, Kazuaki Shimada, Hisashi Narimatsu, Nobuyoshi Hiraoka   +5 more
doaj   +1 more source

Sialyl Lewis x expression in canine malignant mammary tumours: correlation with clinicopathological features and E-Cadherin expression

BMC Cancer, 2007
Background Sialyl Lewis x (sLex) antigen is a carbohydrate antigen that is considered not only a marker for cancer but also implicated functionally in the malignant behaviour of cancer cells. Overexpression of sLex is associated with enhanced progression
Carvalheira Júlio, Marcos Nuno T, Lopes Célia, Matos Augusto JF, Pinho Salomé S, Reis Celso A, Gärtner Fátima   +6 more
doaj   +1 more source

Apple Pomace Pectin for Gastroprotective Nutraceutical Delivery: Structure–Function Relationships and Nano/Microencapsulation Strategies for Gastric Ulcer Management

Food Frontiers, Volume 7, Issue 4, July 2026.
Apple pomace pectin is explored as a sustainable and multifunctional biomaterial for gastric ulcer management. Its unique structural features confer mucoadhesive, anti‐inflammatory, antioxidant, and anti‐Helicobacter pylori activities while enabling nano/microencapsulation of therapeutic agents.
Akash Dhiman, Shefali Arora, Parteek Prasher, Sukanya Chhetri, Pankaj Bhandari, William N. Setzer, Javad Sharifi‐Rad   +6 more
wiley   +1 more source

The high affinity selectin glycan ligand C2-O-sLe^x and mRNA transcripts of the core 2 β-1,6-N-acetylglusaminyltransferase (C2GnT1) gene are highly expressed in human colorectal adenocarcinomas

BMC Cancer, 2009
Background The metastasis of cancer cells and leukocyte extravasation into inflamed tissues share common features. Specialized carbohydrates modified with sialyl Lewis x (sLex) antigens on leukocyte membranes are ligands for selectin adhesion molecules ...
Cao Qing, Jessurun Jose, Gulbahce H Evin, Mitcheltree Gregory, Farooqui Mariya, St Hill Catherine A, Walcheck Bruce   +6 more
doaj   +1 more source

Reprogramming the Immune Landscape of Inflammatory Breast Cancer

Advanced Science, Volume 13, Issue 36, 29 June 2026.
Inflammatory breast cancer is the most lethal subtype of breast cancer and is characterized by an immunosuppressive tumor microenvironment (TME) driven by a complex network of immune cells and inflammatory cytokines, contributing to its aggressiveness and treatment challenges. Immune checkpoint inhibitors, either alone or in combination, show potential
Verena Martinez‐Rodriguez, Suguru Ogata, Xiaoping Wang, Naoto T. Ueno   +3 more
wiley   +1 more source

Combining radiotherapy with CAR‐T cell therapy for solid tumors: Challenges, mechanisms, and future directions

Precision Radiation Oncology, Volume 10, Issue 2, Page 192-204, June 2026.
Radiotherapy enhances CAR‐Tcell therapy by increasing antigenicity, improving trafficking, and reshaping the tumor microenvironment. Despite its dual effects, including potential immune suppression, understanding these mechanisms enables the development of strategies to maximize synergy in solid tumors.
Leran Qiu, Xingyu Zhou, Jiao Xue, Xiaokang Zhang, Songbing Qin   +4 more
wiley   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Serum sialyl Lewis X-i antigen in lung adenocarcinoma and idiopathic pulmonary fibrosis [PDF]

Thorax, 2002
Sialyl Lewis X-i antigen has been used as a diagnostic tool for lung adenocarcinoma. However, serum levels of the antigen are also raised in some patients with idiopathic pulmonary fibrosis (IPF) without coexistent malignancy. Expression of the antigen in serum samples of patients with lung adenocarcinoma was evaluated and compared with that of ...
H, Satoh, H, Ishikawa, Y T, Yamashita, M, Ohtsuka, K, Sekizawa   +4 more
openaire   +2 more sources

Sialylation in Colorectal Cancer Rewires Antitumor Immunity at the Peritoneal Metastatic Site

European Journal of Immunology, Volume 56, Issue 5, May 2026.
This study shows that loss of sialylation in CT26 cells reduces peritoneal tumor burden, correlating with a lower peritoneal cancer index score. These tumors exhibited increased immune infiltration with prominent alterations in the myeloid compartment and immune cell correlations unique to desialylated tumors, indicating profound reshaping of antitumor
Irene van der Haar Àvila, Kristiaan Lenos, Victor Lorrain, Eleonora Nardini, Ernesto Rodríguez, Juan J. García‐Vallejo, Yvette van Kooyk, Joep Grootjans, Sandra J. van Vliet   +8 more
wiley   +1 more source

Quinic Acid and Synthetic Derivatives in Medicinal Chemistry

ChemMedChem, Volume 21, Issue 5, 13 March 2026.
Quinic acid and its derivatives are gaining recognition as versatile scaffolds in drug discovery. This review explores their emerging roles in inflammation, infection, cancer, and metabolic disorders, highlighting recent advances that position them beyond chlorogenic acids as promising platforms for therapeutic innovation. Quinic acid (QA) is a natural
Iago C. Vogel, Manuel J. Verganista, Nuno R. Candeias   +2 more
wiley   +1 more source