Results 21 to 30 of about 7,429 (165)

Glycans Related to the CA19-9 Antigen Are Increased in Distinct Subsets of Pancreatic Cancers and Improve Diagnostic Accuracy Over CA19-9Summary

Cellular and Molecular Gastroenterology and Hepatology, 2016
Background & Aims: The cancer antigen 19-9 (CA19-9) is the current best biomarker for pancreatic cancer, but it is not increased in approximately 25% of pancreatic cancer patients at a cut-off value that provides a 25% false-positive rate.
Huiyuan Tang, Katie Partyka, Peter Hsueh, Jessica Y. Sinha, Doron Kletter, Herbert Zeh, Ying Huang, Randall E. Brand, Brian B. Haab   +8 more
doaj   +1 more source

Adhesion of Helicobacter Species to the Human Gastric Mucosa: A Deep Look Into Glycans Role

Frontiers in Molecular Biosciences, 2021
Helicobacter species infections may be associated with the development of gastric disorders, such as gastritis, peptic ulcers, intestinal metaplasia, dysplasia and gastric carcinoma.
Rita Matos, Rita Matos, Rita Matos, Irina Amorim, Irina Amorim, Irina Amorim, Ana Magalhães, Ana Magalhães, Freddy Haesebrouck, Fátima Gärtner, Fátima Gärtner, Celso A. Reis, Celso A. Reis, Celso A. Reis, Celso A. Reis   +14 more
doaj   +1 more source

Enforced sialyl‐Lewis‐X (sLeX) display in E‐selectin ligands by exofucosylation is dispensable for CD19‐CAR T‐cell activity and bone marrow homing

Clinical and Translational Medicine, 2021
CD19‐directed chimeric antigen receptors (CAR) T cells induce impressive rates of complete response in advanced B‐cell malignancies, specially in B‐cell acute lymphoblastic leukemia (B‐ALL). However, CAR T‐cell‐treated patients eventually progress due to
Diego Sánchez‐Martínez, Francisco Gutiérrez‐Agüera, Paola Romecin, Meritxell Vinyoles, Marta Palomo, Néstor Tirado, Samanta Romina Zanetti, Manel Juan, Michela Carlet, Irmela Jeremias, Pablo Menéndez   +10 more
doaj   +1 more source

Invasive behavior of ulcerative colitis-associated carcinoma is related to reduced expression of CD44 extracellular domain: comparison with sporadic colon carcinoma

Diagnostic Pathology, 2011
Background To elucidate relations of invasion of ulcerative colitis (UC)-associated carcinoma with its prognosis, the characteristics of invasive fronts were analyzed in comparison with sporadic colonic carcinomas.
Araki Kayo, Kikuchi Masaomi, Numata Yoshiko, Yoshida Tsutomu, Mikami Tetuo, Nakada Norihiro, Okayasu Isao   +6 more
doaj   +1 more source

Circulating tumor cells from prostate cancer patients interact with E-selectin under physiologic blood flow. [PDF]

PLoS ONE, 2013
Hematogenous metastasis accounts for the majority of cancer-related deaths, yet the mechanism remains unclear. Circulating tumor cells (CTCs) in blood may employ different pathways to cross blood endothelial barrier and establish a metastatic niche ...
Gunjan Gakhar, Vicente N Navarro, Madelyn Jurish, Guang Yu Lee, Scott T Tagawa, Naveed H Akhtar, Marco Seandel, Yue Geng, He Liu, Neil H Bander, Paraskevi Giannakakou, Paul J Christos, Michael R King, David M Nanus   +13 more
doaj   +1 more source

The Diagnostic Value of Various Immunohistochemical Biomarkers in the Detection of Papillary and Follicular Thyroid Cancers: A Systematic Review and Metaanalysis [PDF]

Journal of Health Sciences and Surveillance System
Background: Thyroid neoplasia is the most common endocrine malignancy worldwide. Fine-needle aspiration biopsy of thyroid nodules has a low sensitivity in distinguishing between benign and malignant lesions.
Mitra Heirdarpour, Yalda Heshmati, Alireza Rahimi, Awat Feizi, Reza Rakhshan, Maryam Ghasemi   +5 more
doaj   +1 more source

Expression of ST3GAL4 leads to SLe(x) expression and induces c-Met activation and an invasive phenotype in gastric carcinoma cells.

PLoS ONE, 2013
Sialyl-Lewis X (SLe(x)) is a sialylated glycan antigen expressed on the cell surface during malignant cell transformation and is associated with cancer progression and poor prognosis.
Catarina Gomes, Hugo Osório, Marta Teixeira Pinto, Diana Campos, Maria José Oliveira, Celso A Reis   +5 more
doaj   +1 more source

Expression of Lewis[x], sialylated Lewis[x], Lewis[a], and sialylated Lewis[a] antigens in human lung carcinoma

The Tohoku Journal of Experimental Medicine, 1991
One hundred and five cases of various human lung neoplasms were studied immunohistochemically using monoclonal antibodies recognizing the antigens, Le(x), sialylated Le(x) (SLEX), Le(a), and sialylated Le(a) (SLEA). Of the 92 lung cancers examined for antigen expression SLEX was detected in 57% (52 cases), Le(x) in 42% (39), SLEA in 36% (33), and Le(a)
openaire   +4 more sources

Systematic chemoenzymatic synthesis of O-sulfated sialyl Lewis x antigens

Chemical Science, 2016
O-Sulfated sialyl Lewisxantigens containing different sialic acid forms were chemoenzymatically synthesized using a bacterial sialyltransferase mutant.
Santra, Abhishek, Yu, Hai, Tasnima, Nova, Muthana, Musleh M, Li, Yanhong, Zeng, Jie, Kenyon, Nicholas J, Louie, Angelique Y, Chen, Xi   +8 more
openaire   +5 more sources

Structure and function of the selectin ligand PSGL-1

Brazilian Journal of Medical and Biological Research, 1999
P-selectin glycoprotein ligand-1 (PSGL-1) is a dimeric mucin-like 120-kDa glycoprotein on leukocyte surfaces that binds to P- and L-selectin and promotes cell adhesion in the inflammatory response.
R.D. Cummings
doaj   +1 more source