Results 11 to 20 of about 4,367 (168)

One-pot multienzyme synthesis of Lewis x and sialyl Lewis x antigens. [PDF]

Curr Protoc Chem Biol, 2012
AbstractL‐Fucose has been found abundantly in human milk oligosaccharides, bacterial lipopolysaccharides, glycolipids, and many N‐ and O‐linked glycans produced by mammalian cells. Fucose‐containing carbohydrates have important biological functions. Alterations in the expression of fucosylated oligosaccharides have been observed in several pathological
Yu H, Lau K, Li Y, Sugiarto G, Chen X.
europepmc   +4 more sources

Glycan motif profiling reveals plasma sialyl-lewis x elevations in pancreatic cancers that are negative for sialyl-lewis A. [PDF]

Mol Cell Proteomics, 2015
The sialyl-Lewis A (sLeA) glycan forms the basis of the CA19-9 assay and is the current best biomarker for pancreatic cancer, but because it is not elevated in ∼25% of pancreatic cancers, it is not useful for early diagnosis. We hypothesized that sLeA-low tumors secrete glycans that are related to sLeA but not detectable by CA19-9 antibodies. We used a
Tang H, Singh S, Partyka K, Kletter D, Hsueh P, Yadav J, Ensink E, Bern M, Hostetter G, Hartman D, Huang Y, Brand RE, Haab BB.   +12 more
europepmc   +3 more sources

Allergic Bronchopulmonary Aspergillosis With Elevated Serum Tumour Marker Levels [PDF]

Respirology Case Reports
We present the case of a 56‐year‐old woman diagnosed with allergic bronchopulmonary aspergillosis (ABPA) who showed multiple nodular shadows on a chest x‐ray.
Hiroaki Ishikawa, Mari Anzai, Ayaka Kishimoto, Tomohiro Namiki, Ryusei Nakagawa, Hiroya Sunabe, Toshihide Inui, Hiroko Watanabe, Yuichi Dai, Tohru Sakamoto   +9 more
doaj   +2 more sources

Chemoenzymatic synthesis of the sialyl Lewis X glycan and its derivatives. [PDF]

Carbohydr Res, 2010
A combination of recombinant FKP and alpha-(1-->3)-fucosyltransferase allows the facile synthesis of the sialyl Lewis X tetrasaccharide glycan and its derivatives in excellent yield. In this system, the universal fucosyl donor, guanidine 5'-diphosphate-beta-L-fucose (GDP-fucose), or its analogues can be generated in situ by cofactor recycling using ...
Soriano del Amo D, Wang W, Besanceney C, Zheng T, He Y, Gerwe B, Seidel RD, Wu P.   +7 more
europepmc   +4 more sources

Essential functions, syntheses and detection of sialyl Lewis X on glycoproteins [PDF]

Exploration of Drug Science, 2023
It is widely acknowledged that sialyl Lewis X (sLeX), the composition and linkage of which are N-acetylneuraminic acid (Neu5Ac) α2-3 galactose (Gal) β1-4 [fucose (Fuc) α1-3] N-acetylglucosamine, is usually attached to the cell surface.
Qiushi Chen, Han Liu, Xuechen Li
doaj   +1 more source

In vitro Evaluation of Sialyl Lewis X Relationship with Head and Neck Cancer Stem Cells [PDF]

Otolaryngology - Head and Neck Surgery, 2013
Vincenzo Desiderio, Petros Papagerakis, John H Owen   +2 more
exaly   +2 more sources

Streptococcus oralis Employs Multiple Mechanisms of Salivary Mucin Binding That Differ Between Strains

Frontiers in Cellular and Infection Microbiology, 2022
Streptococcus oralis is an oral commensal and opportunistic pathogen that can enter the bloodstream and cause bacteremia and infective endocarditis. Here, we investigated the mechanisms of S.
Gurdeep Chahal, Macarena P. Quintana-Hayashi, Meztlli O. Gaytán, John Benktander, Medea Padra, Samantha J. King, Samantha J. King, Samantha J. King, Sara K. Linden   +8 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

alpha2,3-sialyltransferase ST3Gal III modulates pancreatic cancer cell motility and adhesion in vitro and enhances its metastatic potential in vivo. [PDF]

PLoS ONE, 2010
BACKGROUND: Cell surface sialylation is emerging as an important feature of cancer cell metastasis. Sialyltransferase expression has been reported to be altered in tumours and may account for the formation of sialylated tumour antigens.
Marta Pérez-Garay, Beatriz Arteta, Lluís Pagès, Rafael de Llorens, Carme de Bolòs, Fernando Vidal-Vanaclocha, Rosa Peracaula   +6 more
doaj   +1 more source

Chronic kidney disease linked to SARS-CoV-2 infection: a case report

BMC Nephrology, 2021
Background The recent COVID-19 pandemic has raised concerns about patient diagnosis and follow-up of chronically ill patients. Patients suffering from chronic illnesses, concomitantly infected by SARS-CoV-2, globally tend to have a worse prognosis and ...
Georges Tarris, Alexis de Rougemont, Marie-Anaïs Estienney, Julien Journet, Anne-Cécile Lariotte, Damien Aubignat, Jean-Michel Rebibou, Mathilde Funes De La Vega, Mathieu Legendre, Gael Belliot, Laurent Martin   +10 more
doaj   +1 more source