Results 121 to 130 of about 10,746,438 (360)

Hydroxyurea mobile directly observed therapy versus standard monitoring in patients with sickle cell anemia: a phase 2 randomized trial

Communications Medicine
Background Sickle cell anemia (SCA) prevalence remains high in sub-Saharan Africa. Long-term treatment with hydroxyurea (HU) increases survival, however, poor adherence to treatment could limit effectiveness.
Philip Sasi, Abel Makubi, Raphael Z. Sangeda, Mariam Y. Ngaeje, Bruno P. Mmbando, Joseph Soka, Caterina Rosano, Alex S. Magesa, Sharon E. Cox, Julie Makani, Enrico M. Novelli   +10 more
doaj   +1 more source

Sickle Cell Disease: Advances in Treatment

Ochsner Journal, 2018
Background: Sickle cell disease causes significant morbidity and mortality and affects the economic and healthcare status of many countries. Yet historically, the disease has not had commensurate outlays of funds that have been aimed at research and ...
R. Gardner
semanticscholar   +1 more source

The Southern California Healthcare Delivery Science Center: A Model for Aligning Patients, Healthcare Systems, and Researchers to Develop, Test, and Disseminate Innovations to Achieve Health Equity

Learning Health Systems, EarlyView.
ABSTRACT Introduction A key barrier to translating evidence into practice is the paucity of learning health system (LHS) researchers elucidating and addressing barriers to implementation and maintenance. Methods In response to the growing need for a workforce dedicated to translating evidence into practice, we developed the Southern California ...
Amytis Towfighi, Aidan R. Lindgren, Thomas A. Buchanan, Hal F. Yee Jr, Allison Orechwa   +4 more
wiley   +1 more source

Disease knowledge and health literacy in parents of children with sickle cell disease [PDF]

, 2023
Bonaventure G. Ikediashi, Cristina Ehrmann, Selma Gomez, Gisela Michel   +3 more
openalex   +1 more source

Prenatal Exome Sequencing Identifies Dual Maternal‐Fetal Diagnosis of HbF Mission Bay, a Novel HBG2 Variant Associated With Methemoglobinemia, Hypoxia and Hemolytic Anemia

Prenatal Diagnosis, EarlyView.
ABSTRACT Prenatal exome sequencing (ES) can establish rare genetic diagnoses in a fetus but may also lead to occult genetic diagnosis in a biological parent. We present a case of dual fetal and maternal diagnosis by prenatal ES, in a fetus with unexplained anemia and in a pregnant patient with sickle cell disease (SCD) and recurrent unexplained hypoxia.
Matthew A. Shear, Billie Lianoglou, Ugur Hodoglugil, W. Patrick Devine, Ashutosh Lal, Juan Gonzalez, Teresa N. Sparks   +6 more
wiley   +1 more source

The Expanding Role of Gene Sequencing in Shaping Fetal Therapies: Clinical and Ethical Considerations

Prenatal Diagnosis, EarlyView.
ABSTRACT In utero interventions are transformative in addressing genetic and anatomic conditions during fetal development. Next generation sequencing enables early genetic testing, playing a pivotal role in prenatal decision‐making by supporting risk stratification, precise and timely diagnosis, which directly informs eligibility for fetal surgical and
Matthew A. Shear, Beltran Borges, Billie R. Lianoglou, Tony Lum, Emma Canepa, Jennifer L. Cohen, Julia E. H. Brown, Akos Herzeg   +7 more
wiley   +1 more source

Global, Regional, and National Epidemiology of Pediatric Stroke, 1990–2021: A Systematic Analysis From the Global Burden of Disease Study

Pediatric Discovery, EarlyView.
In 2021, the burden of pediatric stroke varied substantially across countries and regions. China and India had the highest prevalence, while India and Nigeria accounted for disproportionately high DALYs, indicating greater health loss per case. Marked geographic disparities underscore the need for region‐specific strategies.
Zhao Yang, Hanxiao Duan, Hao Chen, Hui Hu, Nandi Wang, Tiantian Luo, Jun Tang   +6 more
wiley   +1 more source

Automated red cell exchange in sickle cell disease patients: Retrospective analysis of series of cases in a tertiary care hospital in Eastern India

, 2022
Girijanandini Kanungo, Priyanka Nagrath, Priyanka Samal, Santosh Kumar Mishra   +3 more
openalex   +1 more source

Explosive Weapons Trauma Care Collective (EXTRACCT) Blast Injury Clinical Practice Guideline: Ocular Trauma

World Journal of Surgery, EarlyView.
This clinical practice guideline from the Explosive Weapons Trauma Care Collective (EXTRACCT) group reviews current best practice for the management of ocular trauma in conflict‐affected regions, where explosive weapons are used and healthcare infrastructure is limited.
Emma Butterfield, Alistair Bolt, Gerry Clare, John Mattia, Aung Maw Tin‐U, Iddi Ndyabawe, Larry Schwab, Siegfried Karl Wagner, On behalf of the EXTRACCT Clinical Practice Guidelines Collaboration   +8 more
wiley   +1 more source

Does Sickle Cell Anaemia Have a Relationship With Avascular Pulp Necrosis? A Systematic Review

Australian Endodontic Journal, EarlyView.
ABSTRACT This systematic review examined the relationship between sickle cell disease (SCD), an inherited genetic hemoglobinopathy, and avascular pulp necrosis (APN) in intact teeth. A comprehensive search of eight electronic databases was performed up to December 2024.
Elidiane Elias Ribeiro, Karin Sá Fernandes, Erika Sales Joviano Pereira, Angelica Maria Cupertino Lopes Marinho, Jefferson R. Tenório, Márcia Pereira Alves dos Santos   +5 more
wiley   +1 more source