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Effect of Hydroxyurea on the Frequency of Painful Crises in Sickle Cell Anemia [PDF]
New England Journal of Medicine, 1995 BACKGROUND In a previous open-label study of hydroxyurea therapy, the synthesis of fetal hemoglobin increased in most patients with sickle cell anemia, with only mild myelotoxicity.
Samuel Charache +7 more
openalex +2 more sources
Sexuality and sickle cell anemia
Revista Brasileira de Hematologia e Hemoterapia, 2013 BACKGROUND: Sickle cell disease, the most common hereditary blood disease in the world, is the result of an atypical hemoglobin called S (Hb S) which, when homozygous (Hb SS) is the cause of sickle cell anemia.
Viviane de Almeida Côbo +4 more
doaj +5 more sources
Coexistent sickle cell anemia and autoimmune hemolytic anemia in two adolescents [PDF]
Einstein (São Paulo)The development of alloantibodies or autoantibodies is a complication observed in sickle cell disease. Autoimmunization occurs in 7.6-12% of chronically or intermittently transfused patients with sickle cell disease; however, the clinical implications of
Vinícius Reis Soares +3 more
doaj +2 more sources
Reversibility of Red blood Cell deformation [PDF]
, 2011 The ability of cells to undergo reversible shape changes is often crucial to their survival. For Red Blood Cells (RBCs), irreversible alteration of the cell shape and flexibility often causes anemia. Here we show theoretically that RBCs may react irreversibly to mechanical perturbations because of tensile stress in their cytoskeleton.
C. T. Noguchi +5 more
arxiv +3 more sources
Phase 1 Study of the E-Selectin Inhibitor GMI 1070 in Patients with Sickle Cell Anemia [PDF]
PLoS ONE, 2014 Background\ud \ud Sickle cell anemia is an inherited disorder of hemoglobin that leads to a variety of acute and chronic complications. Abnormal cellular adhesion, mediated in part by selectins, has been implicated in the pathophysiology of the vaso ...
Cheung, Anthony +10 more
core +4 more sources
Comparison of Asymptomatic Brain Lesions Between Thalassemia Major and Sickle Cell Anemia Patients [PDF]
MedicinaBackground and Objectives: This study aimed to identify asymptomatic brain lesions in patients with β-thalassemia major (TM) and sickle cell anemia (SCA) and evaluate the correlation of these lesions with factors such as splenectomy, thrombocytosis, and ...
Derya Yavuz Demiray +2 more
doaj +2 more sources
Haematologica, 2016 Sickle cell anemia is a manifestation of a single point mutation in hemoglobin, but inflammation and pain are the insignia of this disease which can start in infancy and continue throughout life.
Lucile Vincent +5 more
doaj +2 more sources
RadioGraphics, 2001 Sickle cell anemia (SCA) is a disease caused by production of abnormal hemoglobin, which binds with other abnormal hemoglobin molecules within the red blood cell to cause rigid deformation of the cell. This deformation impairs the ability of the cell to pass through small vascular channels; sludging and congestion of vascular beds may result, followed ...
Gael J. Lonergan +2 more
+6 more sources
Role of sickling crisis with serum zinc in children with sickle cell anemia
Advanced Medical Journal, 2022 Background and objectives: Sickle cell anemia causes painful crises by the occlusion of small blood vessels by spontaneous intravascular sickling. The aim of this study is to determine the possible association of Zinc deficiency with painful crises ...
Bahzad Khalid Sharaf +1 more
doaj +1 more source