Revisiting anemia in sickle cell disease and finding the balance with therapeutic approaches [PDF]
Julia Xu, Swee Lay Thein
openalex +1 more source
Abstract Background Blood transfusion remains a cornerstone in the management of sickle cell disease (SCD); however, it is frequently complicated by red cell alloimmunisation. A significant debate persists within the scientific community regarding the optimal strategy to mitigate this risk: the traditional, pragmatic approach of serologic phenotyping ...
Christiane Ruffato Carminati +6 more
wiley +1 more source
Abstract Background Platelet transfusions are an important tool to prevent and stop bleeding. Thresholds for pretransfusion platelet counts have been studied in various patient populations, yielding evidence‐based guidelines. The Association for the Advancement of Blood and Biotherapies (AABB) collaborated with the International Collaboration for ...
Rylee Yakymi, Claudia S. Cohn
wiley +1 more source
Speciation in the baboon and its relation to gamma-chain heterogeneity and to the response to induction of HbF by 5-azacytidine [PDF]
In the baboon (Papio species), the two nonallelic gamma-genes produce gamma-chains that differ at a minimum at residue 75, where isoleucine (I gamma-chain) or valine (V gamma) may be present.
DeSimone, Joseph +7 more
core
Comparison of Asymptomatic Brain Lesions Between Thalassemia Major and Sickle Cell Anemia Patients
Background and Objectives: This study aimed to identify asymptomatic brain lesions in patients with β-thalassemia major (TM) and sickle cell anemia (SCA) and evaluate the correlation of these lesions with factors such as splenectomy, thrombocytosis, and ...
Derya Yavuz Demiray +2 more
doaj +1 more source
Hydroxyurea as secondary prevention for stroke in children with sickle cell anemia [PDF]
Michael R. DeBaun
openalex +1 more source
Predictors of impending acute chest syndrome in patients with sickle cell anaemia. [PDF]
Acute chest syndrome (ACS) is a major complication of sickle cell anaemia (SCA) and a leading cause for hospital admissions and death. We aimed to study the spectrum of clinical and laboratory features of ACS and to assess the predisposing factors and ...
Al-Busaidi, Ikhlas +5 more
core +1 more source
Massive splenic infarction in Saudi patients with sickle cell anemia: A unique manifestation [PDF]
Ali Jama +2 more
openalex +1 more source
The perception of pediatric sickle cell anemia patient's caregivers toward hematopoietic stem cell transplantation (single-center experience, Saudi Arabia) [PDF]
Dania A. Monagel +7 more
openalex +1 more source
Cost‐effectiveness of a hypothetical assay to evaluate stored blood quality prior to transfusion
Abstract Background and Objectives Unsuccessful red blood cell (RBC) transfusion, necessitating unscheduled repeat transfusion, is common and costly. Several technologies have been developed to assess stored blood quality, but the potential cost‐effectiveness of pretransfusion testing versus no testing to prevent unscheduled re‐transfusion is unknown ...
Melissa C. Caughey +3 more
wiley +1 more source

