Results 11 to 20 of about 247,564 (312)

Identification of Sickle Cell Anemia Using Deep Neural Networks

, 2021
A molecule called hemoglobin is found in red blood cells that holds oxygen all over the body. Hemoglobin is elastic, round, and stable in a healthy human. This makes it possible to float across red blood cells.
Sagar Yeruva, M. Varalakshmi, B. Gowtham, Y. Chandana, P. K. Prasad   +4 more
semanticscholar   +1 more source

Deep Learning Models for Classification of Red Blood Cells in Microscopy Images to Aid in Sickle Cell Anemia Diagnosis

Electronics, 2020
Sickle cell anemia, which is also called sickle cell disease (SCD), is a hematological disorder that causes occlusion in blood vessels, leading to hurtful episodes and even death.
Laith Alzubaidi, M. Fadhel, O. Al-Shamma, Jinglan Zhang, Y. Duan   +4 more
semanticscholar   +1 more source

Splenic sequestration and infarction upon exposure to high altitude in adult patients with sickle cell anemia

Journal of Applied Hematology, 2023
Adult patients with sickle cell disease usually have atrophied spleens due to autosplenectomy, and only rarely have complications related to the spleen, such as splenic sequestration and infarctions.
Husain Alkhaldy, Mortadah Alsalman, Mariyyah Almuhaini, Renad Alshehri, Samar Almusaad, Wejdan Al-Qahtani, Tamer A Samih, Mohammed Makkawi   +7 more
doaj   +1 more source

Hydroxyurea Dose Escalation for Sickle Cell Anemia in Sub-Saharan Africa.

New England Journal of Medicine, 2020
BACKGROUND Hydroxyurea has proven safety, feasibility, and efficacy in children with sickle cell anemia in sub-Saharan Africa, with studies showing a reduced incidence of vaso-occlusive events and reduced mortality.
C. John, R. Opoka, Teresa S. Latham, H. Hume, Catherine Nabaggala, Phillip Kasirye, C. Ndugwa, A. Lane, R. Ware   +8 more
semanticscholar   +1 more source

The multifaceted role of ischemia/reperfusion in sickle cell anemia.

Journal of Clinical Investigation, 2020
Sickle cell anemia is a unique disease dominated by hemolytic anemia and vaso-occlusive events. The latter trigger a version of ischemia/reperfusion (I/R) pathobiology that is singular in its origin, cyclicity, complexity, instability, perpetuity, and ...
R. Hebbel, J. Belcher, G. Vercellotti
semanticscholar   +1 more source

Treating sickle cell anemia

Science, 2020
New drugs, stem cell transplants, and gene therapy show promise in treating sickle cell anemia Sickle cell anemia is an inherited disorder caused by a point mutation (affecting a single nucleotide) in the gene that encodes the β-globin chain of ...
J. Tisdale, S. Thein, W. Eaton
semanticscholar   +1 more source

The Fabulous Impact of CRISPR Method in Sickle Cell Disease Treatment

Trends in Peptide and Protein Sciences, 2021
Sickle cell diseases are the most prevalent monogenic blood diseases with complications such as severe end-organ harm, pain, and reduced life expectancy. Dealing options for sickle cell diseases are inadequate, as there are just two FDA-approved drugs to
Vida Ebrahimi, Atieh Hashemi
doaj   +1 more source

Fetal Hemoglobin in Sickle Cell Anemia.

Blood, 2020
Fetal hemoglobin (HbF) can blunt the pathophysiology, temper the clinical course and offer prospects for curative therapy of sickle cell disease. This review focuses on: 1.
M. Steinberg
semanticscholar   +1 more source

HEMATOPOIETIC STEM CELL TRANSPLANTATION IN THALASSEMIA AND SICKLE CELL DISEASE: EXPERIENCE OF MEDITERRANEAN INSTITUTE OF HEMATOLOGY IN A MULTI-ETHNIC POPULATION.

Mediterranean Journal of Hematology and Infectious Diseases, 2009
Hematopoietic stem cell transplantation (HSCT) still remains the only definitive cure currently available for patients with thalassemia and sickle cell anemia.
Marco Marziali, Antonella Isgrò, Javid Gaziev, Guido Lucarelli   +3 more
doaj   +1 more source

Peripheral Red Blood Cell Split Chimerism as a Consequence of Intramedullary Selective Apoptosis of Recipient Red Blood Cells in a Case of Sickle Cell Disease

Mediterranean Journal of Hematology and Infectious Diseases, 2014
Allogeneic cellular gene therapy through hematopoietic stem cell transplantation is the only radical cure for congenital hemoglobinopathies like thalassemia and sickle cell anemia.
Marco Marziali, Antonella Isgrò, Pietro Sodani, Javid Gaziev, Daniela Fraboni, Katia Paciaroni, Cristiano Gallucci, Cecilia Alfieri, Andrea Roveda, Gioia De Angelis, Luisa Cardarelli, Michela Ribersani, Marco Andreani, Guido Lucarelli   +13 more
doaj   +1 more source