Results 111 to 120 of about 88,496 (299)

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

Economic burden and quality of life of caregivers of patients with sickle cell disease in the United Kingdom and France: a cross-sectional study

Journal of Patient-Reported Outcomes
Background Sickle cell disease (SCD), a genetic blood disorder that affects red blood cells and oxygen delivery to body tissues, is characterized by haemolytic anaemia, pain episodes, fatigue, and end-organ damage with acute and chronic dimensions ...
Martin Besser, Sian Bissell O’Sullivan, Siobhan Bourke, Louise Longworth, Giovanna Tedesco Barcelos, Yemi Oluboyede   +5 more
doaj   +1 more source

3 Tips for Safe Use of Medicines for People with Sickle Cell Disease [French]

3 Tips for Safe Use of Medicines for People with Sickle Cell Disease [French]Les personnes atteintes de dr\ue9panocytose se voient souvent prescrire des m\ue9dicaments pour les complications fr\ue9quentes de la dr\ue9panocytose.CS 319852-MPublication ...

core  

Hair‐on‐end sign in severe sickle cell disease

British Journal of Haematology, EarlyView.
Raquel da Costa Neves, Joana Pais de Faria, Paula Kjöllerström   +2 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Hemodynamic profile of cerebral arteries using transcranial Doppler in children with sickle cell disease compared to children without sickle cell disease: Prospective analytical study

BMC Pediatrics
Background Cerebral vasculopathy is a frequent and serious complication of major sickle cell disease syndromes. Transcerebral Doppler (TCD) can detect stenosis of the main arteries at the base of the skull before stroke occurs, and initiate therapy to ...
Patrick Landu Kinkunda, Aliocha Natuhoyila Nkodila, Joël Kashale Mutamba, Orlin Mamona Yindula, Roger Izeidi Gangale, Lilly Mokulayanga, Émeraude Manzombi, Djo Mbo-M. Iyoto, Lys Makwanza, Cynthia Bukumba Minouche, Stéphane Tongo Yanda, Antoine Aundu Molua, Jean Tshibola Mukaya   +12 more
doaj   +1 more source

Integrating primary care for depression management during transition in sickle cell disease: A pre–post feasibility study

British Journal of Haematology, EarlyView.
Robert M. Cronin, Nives Quaye, Kristina Landes, Roberta Azbell, Sherraine Della‐Moretta, Regina D. Crawford, Chyongchiou J. Lin, Susan Creary, Patrick M. Schnell   +8 more
wiley   +1 more source

Seventh Åland Island Meeting on von Willebrand Disease

Haemophilia, EarlyView.
ABSTRACT Introduction The seventh Åland Island Meeting on von Willebrand Disease (VWD) was held on the Åland archipelago in Finland, from 26 to 28 September 2024. Aim The meeting brought together experts in the field of VWD from around the world to share the latest advances and knowledge in VWD.
Riitta Lassila, Ruben Bierings, Nathan T. Connell, Fernando F. Corrales‐Medina, Augusto B. Federici, Veronica H. Flood, Floor Heubel‐Moenen, Jill M. Johnsen, Geoffrey Kuppens, Davide Matino, Carolyn Millar, Ingmar Schoen, Anish Sharda, Robert F. Sidonio Jr, Alok Srivastava, Timea Szanto, Angela C. Weyand, Erik Berntorp   +17 more
wiley   +1 more source

The Bloodline newsletter : Sickle Cell Data Collection (SCDC) Program quarterly newsletter ; Summer 2019

Mission: To improve quality of life, life expectancy, and health among people living with sickle cell disease (SCD)

core   +1 more source

Outcomes of dengue infection in adults with underlying haematological diseases in Brazil during 2024 and 2025

British Journal of Haematology, EarlyView.
K. Tozatto‐Maio, V. Weihermann, C. W. Erthal, M. W. Araújo, C. R. Gomes, K. Caciola, L. Otuyama, J. Gasparini, H. R. Higashino, S. F. Costa, A. N. Duarte‐Neto, F. S. Seguro, P. R. Villaça, E. D. R. P. Velloso, S. F. M. Gualandro, Y. Nukui, V. Rocha   +16 more
wiley   +1 more source