Results 111 to 120 of about 9,174,709 (287)

Carrying a crisis: The risk of a painful sickle cell crisis during pregnancy

British Journal of Haematology, EarlyView.
Commentary on: Auger et al. Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes. Br J Haematol 2026 (Online ahead of print). doi: 10.1111/bjh.70837.
Bart J. Biemond
wiley   +1 more source

Hemodynamic profile of cerebral arteries using transcranial Doppler in children with sickle cell disease compared to children without sickle cell disease: Prospective analytical study

BMC Pediatrics
Background Cerebral vasculopathy is a frequent and serious complication of major sickle cell disease syndromes. Transcerebral Doppler (TCD) can detect stenosis of the main arteries at the base of the skull before stroke occurs, and initiate therapy to ...
Patrick Landu Kinkunda, Aliocha Natuhoyila Nkodila, Joël Kashale Mutamba, Orlin Mamona Yindula, Roger Izeidi Gangale, Lilly Mokulayanga, Émeraude Manzombi, Djo Mbo-M. Iyoto, Lys Makwanza, Cynthia Bukumba Minouche, Stéphane Tongo Yanda, Antoine Aundu Molua, Jean Tshibola Mukaya   +12 more
doaj   +1 more source

Ultrasound-Guided Peripheral Venous Catheter for Automated Erythrocytapheresis in a Paediatric Population Affected by Sickle Cell Disease. [PDF]

EJHaem
ABSTRACT Introduction Automated erythrocytapheresis (aEEX) is an effective therapy for severe sickle cell disease (SCD). Its use in paediatrics can be limited by challenges in obtaining reliable venous access. Methods We conducted a retrospective, single‐centre study to evaluate the safety and feasibility of ultrasound (US)‐guided peripheral venous ...
Ocello L, Pavan F, Ferrari GM, Guerra F, Moretto A, Tassistro E, Valsecchi MG, Lepri I, Gregorio L, Passoni A, Balduzzi A, Baldini V, Corti P.   +12 more
europepmc   +2 more sources

Steps to Better Kidney Health for People with Sickle Cell Disease [French]

Steps to Better Kidney Health for People with Sickle Cell Disease [French]Les personnes atteintes de dr\ue9panocytose pr\ue9sentent un risque plus important que la population g\ue9n\ue9rale d\u2019avoir des complications r\ue9nales. Vous trouverez ci-apr\

core  

Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes

British Journal of Haematology, EarlyView.
Summary We assessed the pregnancy outcomes of patients with sickle cell crises. We carried out a retrospective study of 2 698 556 pregnancies in Quebec, Canada between 1989 and 2022. The primary exposure was sickle cell anaemia with crisis during or outside of pregnancy. Outcomes included severe maternal morbidity and other pregnancy complications.
Nathalie Auger, Émilia Mailhot‐Diaferia, Gabriel Côté‐Corriveau, Gilles Paradis, Antoine Lewin, Aimina Ayoub, Anne‐Marie Parrot, Ashley Park, Brian Potter   +8 more
wiley   +1 more source

Will Extended‐Valency Pneumococcal Conjugate Vaccines Offer Enhanced Coverage Against Invasive Pneumococcal Disease for At‐Risk Children?

Acta Paediatrica, EarlyView.
Robert Cohen, Corinne Levy, Naim Ouldali, Stéphane Béchet, Aude Estivaux, André Birgy, Isabelle Hau, IPD Study Group, Emmanuelle Varon   +8 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, EarlyView.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation. Methods We conducted an observational before‐and‐after study including the first non‐tunnelled CVC insertion ...
Mathias Lazarevic Lindblad, Elin Pålsson, Vladimir Lazarevic, Leila Naddi, Ola Borgquist, Lars Nilsson, Maria Adrian, Björn P. Bark, Thomas Kander   +8 more
wiley   +1 more source

O-10: SICKLE CELL HEALTH AWARENESS, PERSPECTIVES AND EXPERIENCES (SHAPE) SURVEY: FINDINGS ON THE BURDEN OF SICKLE CELL DISEASE AND UNMET NEEDS AS REPORTED BY PATIENTS AND CAREGIVERS

HemaSphere, 2022
ODAME I., ANDERSON A., COSTA F., INUSA B., JASTANIAH W., KUNZ J., AL KADHEM Z., TINGA B., BA D., INGOLI E., JAMES J., CLARK A., BEAUBRUN A., LARTEY B., DE MONTALEMBERT M.   +14 more
doaj   +1 more source