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Infections in sickle cell disease
Sickle cell disease (SCD) is one of the commonest severe inherited disorders in the world. Infection accounts for a significant amount of the morbidity and mortality, particularly in sub- Saharan Africa, but is relatively poorly studied and characterized.
Lily E.A. Scourfield +3 more
openaire +3 more sources
Gene therapy is revolutionizing treatment paradigms for haemoglobinopathies, establishing a translational framework for disorders that impact red blood cell development. In their paper, Joshi et al. describe the preclinical and early clinical landscape of gene therapies for non‐haemoglobinopathy erythroid disorders and highlight common thematic ...
Gaurav Joshi +3 more
wiley +1 more source
Predict less, prevent more: A familiar mantra for sickle cell anaemia?
Commentary on: Sommet J, Boizeau P, Haouari Z, et al. Identification of predictive factors for reversal of cerebral vasculopathy in an original longitudinal cohort study in newborns with sickle cell anaemia. Br J Haematol. 2026 (Online ahead of print). doi: 10.1111/bjh.70726.
Charles T. Quinn
wiley +1 more source
Summary Cerebral macrovasculopathy (CV) is a major complication in children with sickle cell anaemia (SCA) and usually requires a long‐term transfusion programme (TP) to prevent stroke. This study aimed to identify factors predicting reversal of CV on TP in a single‐centre newborn cohort. Among 375 patients, 50 presented CV and received TP.
Julie Sommet +16 more
wiley +1 more source
Background Sickle cell disease (SCD), a genetic blood disorder that affects red blood cells and oxygen delivery to body tissues, is characterized by haemolytic anaemia, pain episodes, fatigue, and end-organ damage with acute and chronic dimensions ...
Martin Besser +5 more
doaj +1 more source
3 Tips for Safe Use of Medicines for People with Sickle Cell Disease [French]
3 Tips for Safe Use of Medicines for People with Sickle Cell Disease [French]Les personnes atteintes de dr\ue9panocytose se voient souvent prescrire des m\ue9dicaments pour les complications fr\ue9quentes de la dr\ue9panocytose.CS 319852-MPublication ...
core
Mission: To improve quality of life, life expectancy, and health among people living with sickle cell disease (SCD)
core +1 more source
Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections between 2023 and 2025, including symptoms, laboratory parameters ...
Matthias Bleeke +42 more
wiley +1 more source
Background: One of the major challenges for children and adolescents with sickle cell disease (SCD) is academic performance. Objectives: Our study aimed to evaluate the academic performance of children and adolescents with SCD in Benin and compare it to ...
Bonaventure G. Ikediashi +8 more
doaj +1 more source

