Results 121 to 130 of about 9,174,709 (287)
Mission: To improve quality of life, life expectancy, and health among people living with sickle cell disease (SCD)
core
The FEBS Journal, EarlyView.Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley +1 more source
Mission: To improve quality of life, life expectancy, and health among people living with sickle cell disease (SCD)
core
Gene Editing for Haemophilia—The Next Frontier
Haemophilia, EarlyView.ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti +3 more
wiley +1 more source
Haemophilia, EarlyView.ABSTRACT Introduction Patients with inherited bleeding and haemoglobin disorders face barriers to accessing timely dental care, increasing the risk of untreated oral disease and complications related to invasive procedures. Aim To evaluate the agreement between smartphone‐based asynchronous teledentistry and face‐to‐face examination for oral conditions,
Victor Cordeiro da Silva +7 more
wiley +1 more source
MANAGEMENT OF CHILDREN WITH SICKLE CELL DISEASE IN EUROPE: CURRENT SITUATION AND FUTURE PERSPECTIVES
European Medical Journal Hematology, 2016 Sickle cell disease (SCD) is the most common haemoglobinopathy worldwide and its frequency has steadily increased in Europe in the past decades. SCD is a complex multisystem disorder characterised by chronic haemolytic anaemia, vaso-occlusive crisis, and
Raffaella Colombatti, Laura Sainati
doaj
Blood Cell Counts and the Duffy Null Phenotype: Beyond Neutropenia
International Journal of Laboratory Hematology, EarlyView.ABSTRACT The absence of Duffy antigen expression on red blood cells, caused by a single nucleotide polymorphism in the DARC/ACKR1 gene, confers protection against malaria and is associated with lower absolute neutrophil counts (ANC) in some studied populations.
Elvira Deolinda R. P. Velloso +11 more
wiley +1 more source