Results 11 to 20 of about 88,496 (299)

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

Retrovirology, 2018
Background HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functionality. Results Mass spectrometry
Andrey Ivanov, Xionghao Lin, Tatiana Ammosova, Andrey V. Ilatovskiy, Namita Kumari, Hatajai Lassiter, Nowah Afangbedji, Xiaomei Niu, Michael G. Petukhov, Sergei Nekhai   +9 more
doaj   +1 more source

Nutritional status, hospitalization and mortality among patients with sickle cell anemia in Tanzania. [PDF]

, 2011
BACKGROUND: Reduced growth is common in children with sickle cell anemia, but few data exist on associations with long-term clinical course. Our objective was to determine the prevalence of malnutrition at enrollment into a hospital-based cohort and ...
Soka, Deogratius, Prentice, AM, Komba, Albert N, Prentice, Andrew M, C. R. Newton, A. M. Prentice, Komba, AN, Williams, TN, Fulford, AJ, Makani, J, Newton, Charles R, S. E. Cox, D. Soka, Newton, CR, A. N. Komba, Soka, D, Marsh, K, Cox, SE, Fulford, Anthony J, K. Marsh, Williams, Thomas N, J. Makani, Cox, Sharon E, Williams, Thomas, Makani, Julie, Marsh, Kevin, T. N. Williams, A. J. Fulford   +27 more
core   +1 more source

Protein Phosphatase-1 Regulates Expression of Neuregulin-1

Biology, 2016
Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova, Kareem Washington, Jamie Rotimi, Namita Kumari, Kahli A. Smith, Xiaomei Niu, Marina Jerebtsova, Sergei Nekhai   +7 more
doaj   +1 more source

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

Blood Advances, 2016
: The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment suggests a potential restriction of HIV-1 infection in SCD. We
Namita Kumari, Tatiana Ammosova, Sharmin Diaz, Xionghao Lin, Xiaomei Niu, Andrey Ivanov, Marina Jerebtsova, Subhash Dhawan, Patricia Oneal, Sergei Nekhai   +9 more
doaj   +1 more source

Incidence, kinetics, and risk factors for intra- and extracranial cerebral arteriopathies in a newborn sickle cell disease cohort early assessed by transcranial and cervical color Doppler ultrasound

Frontiers in Neurology, 2022
The risk of stroke in children with sickle cell disease (SCD) is detected by abnormal intracranial arterial time-averaged mean of maximum velocities (TAMVs ≥200 cm/s).
Françoise Bernaudin, Françoise Bernaudin, Cécile Arnaud, Annie Kamdem, Isabelle Hau, Fouad Madhi, Camille Jung, Ralph Epaud, Suzanne Verlhac   +8 more
doaj   +1 more source

Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin

Haematologica, 2013
Ferroportin Q248H mutation has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. Some investigators have reported that ferroportin Q248H is degraded after
Sergei Nekhai, Min Xu, Altreisha Foster, Ishmael Kasvosve, Sharmin Diaz, Roberto F. Machado, Oswaldo L. Castro, Gregory J. Kato, James G. Taylor, Victor R. Gordeuk   +9 more
doaj   +1 more source

Bacterial Infection in the Sickle Cell Population: Development and Enabling Factors

Microorganisms, 2023
The high frequency of bacterial infections represents a major threat to public health. In developing countries, they are still responsible for significant morbidity and mortality in pediatric populations with sickle cell disease, particularly in children
Lucrèce M. Délicat-Loembet, Mohamed Ag Baraïka, Flabou Bougoudogo, Dapa A. Diallo   +3 more
doaj   +1 more source

Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study. [PDF]

, 2009
BACKGROUND: In sub-Saharan Africa, more than 90% of children with sickle-cell anaemia die before the diagnosis can be made. The causes of death are poorly documented, but bacterial sepsis is probably important.
Uyoga, Sophie, Berkley, James, Macharia, Alex, McAuley, Charlotte F, Opi, DH, Kevin Marsh, J Anthony G Scott, Mwarumba, Salim, Berkley, James A, Ndila, C, Scott, John, Carolyne Ndila, Berkley, JA, Thomas N Williams, Sophie Uyoga, Williams, TN, Makani, J, James A Berkley, Sharif, SK, McAuley, CF, Daniel H Opi, Mwarumba, S, Uyoga, S, Macharia, A, Albert Komba, Marsh, K, Scott, JA, Charlotte F McAuley, Sharif, Shahnaaz K, Scott, J Anthony G, Williams, Thomas N, Julie Makani, Ndiritu, Moses N, Salim Mwarumba, Moses N Ndiritu, Komba, Albert, Williams, Thomas, Komba, A, Opi, Daniel H, Makani, Julie, Marsh, Kevin, Ndiritu, MN, Alex Macharia, Shahnaaz K Sharif, Ndila, Carolyne   +44 more
core   +1 more source

Disease knowledge and health literacy in parents of children with sickle cell disease

eJHaem, 2023
We aimed to (1) describe sickle cell disease (SCD) knowledge and health literacy levels in parents of children with SCD, (2) examine associations with socio‐demographic factors and (3) analyse the association with hospital admissions and frequency of ...
Bonaventure G. Ikediashi, Cristina Ehrmann, Selma Gomez, Gisela Michel   +3 more
doaj   +1 more source

Development of multi-level standards of care recommendations for sickle cell disease: Experience from SickleInAfrica

Frontiers in Genetics, 2023
Introduction: Sickle Cell Disease (SCD) causes significant morbidity and mortality particularly in sub-Saharan Africa (SSA) where it contributes to early childhood deaths.
Vivian Paintsil, Vivian Paintsil, Mwashungi Ally, Hezekiah Isa, Kofi A. Anie, Josephine Mgaya, Malula Nkanyemka, Victoria Nembaware, Yaa Gyamfua Oppong-Mensah, Flora Ndobho, Lulu Chirande, Abel Makubi, Obiageli Nnodu, Ambroise Wonkam, Julie Makani, Kwaku Ohene-Frempong   +15 more
doaj   +1 more source