Results 11 to 20 of about 178,306 (248)

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

Retrovirology, 2018
Background HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functionality. Results Mass spectrometry
Andrey Ivanov, Xionghao Lin, Tatiana Ammosova, Andrey V. Ilatovskiy, Namita Kumari, Hatajai Lassiter, Nowah Afangbedji, Xiaomei Niu, Michael G. Petukhov, Sergei Nekhai   +9 more
doaj   +1 more source

Conjugate Haemophilus influenzae type b vaccines for sickle cell disease. [PDF]

, 2016
BACKGROUND: People affected with sickle cell disease are at high risk of infection from Haemophilus influenzae type b. Before the implementation of Haemophilus influenzae type b conjugate vaccination in high-income countries, this was responsible for a ...
Allali, Slimane, Ballas, Samir K., Chalumeau, Martin, de Montalembert, Mariane, Launay, Odile   +4 more
core   +2 more sources

Treatment of dental complications in sickle cell disease. [PDF]

, 2016
BACKGROUND: Sickle cell disease is the most common single gene disorder and the commonest haemoglobinopathy found with high prevalence in many populations across the world.
Abas, Adinegara B L, Ballas, Samir K., Karanth, Laxminarayan, Mulimani, Priti   +3 more
core   +2 more sources

Protein Phosphatase-1 Regulates Expression of Neuregulin-1

Biology, 2016
Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova, Kareem Washington, Jamie Rotimi, Namita Kumari, Kahli A. Smith, Xiaomei Niu, Marina Jerebtsova, Sergei Nekhai   +7 more
doaj   +1 more source

Increased iron export by ferroportin induces restriction of HIV-1 infection in sickle cell disease

Blood Advances, 2016
: The low incidence of HIV-1 infection in patients with sickle cell disease (SCD) and inhibition of HIV-1 replication in vitro under the conditions of low intracellular iron or heme treatment suggests a potential restriction of HIV-1 infection in SCD. We
Namita Kumari, Tatiana Ammosova, Sharmin Diaz, Xionghao Lin, Xiaomei Niu, Andrey Ivanov, Marina Jerebtsova, Subhash Dhawan, Patricia Oneal, Sergei Nekhai   +9 more
doaj   +1 more source

Haemoglobinopathies and newborn haemoglobinopathy screening in Germany. [PDF]

, 2009
Germany has been an immigration country since the early 1950s. In December 2007, 6.7 million non-German citizens lived in the country. However, the total number of citizens with a migration background is 15–20 million, about 9 million of whom come ...
Dickerhoff, R., Genzel-Boroviczeny, Orsolya, Kohne, E.   +2 more
core   +1 more source

Incidence, kinetics, and risk factors for intra- and extracranial cerebral arteriopathies in a newborn sickle cell disease cohort early assessed by transcranial and cervical color Doppler ultrasound

Frontiers in Neurology, 2022
The risk of stroke in children with sickle cell disease (SCD) is detected by abnormal intracranial arterial time-averaged mean of maximum velocities (TAMVs ≥200 cm/s).
Françoise Bernaudin, Françoise Bernaudin, Cécile Arnaud, Annie Kamdem, Isabelle Hau, Fouad Madhi, Camille Jung, Ralph Epaud, Suzanne Verlhac   +8 more
doaj   +1 more source

Sickle cell anaemia and the experiences of young people living with the condition [PDF]

, 2018
This qualitative literature review examines the experiences of young people with Sickle Cell Anaemia (SCA). Sickle cell anaemia (SCA) is a condition acknowledged for its unpredictability, painful episodes and life threatening nature.
Ellis, M.R.C., Foster, N.
core   +1 more source

Of pools, oceans, and the Dead Sea. [PDF]

, 2017
In a comprehensive study in this issue of Blood, Carden and colleagues describe the importance of the tonicity of IV fluids used in the treatment of patients with sickle cell disease (SCD) during vaso-occlusive crises (VOCs).
Ballas, Samir K.
core   +2 more sources

Reduced sensitivity of the ferroportin Q248H mutant to physiological concentrations of hepcidin

Haematologica, 2013
Ferroportin Q248H mutation has an allele frequency of 2.2–13.4% in African populations and is associated with a mild tendency to increased serum ferritin in the general population. Some investigators have reported that ferroportin Q248H is degraded after
Sergei Nekhai, Min Xu, Altreisha Foster, Ishmael Kasvosve, Sharmin Diaz, Roberto F. Machado, Oswaldo L. Castro, Gregory J. Kato, James G. Taylor, Victor R. Gordeuk   +9 more
doaj   +1 more source