Results 211 to 220 of about 70,815 (255)
Some of the next articles are maybe not open access.
Lancet, The, 2004
With the global scope of sickle-cell disease, knowledge of the countless clinical presentations and treatment of this disorder need to be familiar to generalists, haematologists, internists, and paediatricians alike. Additionally, an underlying grasp of sickle-cell pathophysiology, which has rapidly accrued new knowledge in areas related to erythrocyte
Marie J Stuart
exaly +5 more sources
With the global scope of sickle-cell disease, knowledge of the countless clinical presentations and treatment of this disorder need to be familiar to generalists, haematologists, internists, and paediatricians alike. Additionally, an underlying grasp of sickle-cell pathophysiology, which has rapidly accrued new knowledge in areas related to erythrocyte
Marie J Stuart
exaly +5 more sources
Annals of Internal Medicine, 2021
Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point mutation that leads to the production of hemoglobin S. Sickle cell disease is associated with hemolytic anemia, significant chronic end-organ damage, and early death. In high-
Lydia H, Pecker, Sophie, Lanzkron
openaire +2 more sources
Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point mutation that leads to the production of hemoglobin S. Sickle cell disease is associated with hemolytic anemia, significant chronic end-organ damage, and early death. In high-
Lydia H, Pecker, Sophie, Lanzkron
openaire +2 more sources
Nursing Standard, 2016
Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
openaire +4 more sources
Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
openaire +4 more sources
Pediatric Clinics of North America, 2002
Sickle cell disease is a serious and life threatening disease that affects approximately 1 in 600 African-Americans. Since its first description in 1910 by Herrick, our understanding and treatment of this disease has grown tremendously. Most pediatricians will encounter one or more children with sickle cell disease and should have a thorough ...
Jason, Fixler, Lori, Styles
openaire +2 more sources
Sickle cell disease is a serious and life threatening disease that affects approximately 1 in 600 African-Americans. Since its first description in 1910 by Herrick, our understanding and treatment of this disease has grown tremendously. Most pediatricians will encounter one or more children with sickle cell disease and should have a thorough ...
Jason, Fixler, Lori, Styles
openaire +2 more sources
Archives of Pediatrics & Adolescent Medicine, 1979
Sir.—A recentJournalreport by Buchanan and Glader entitled, "Leukocyte Counts in Children With Sickle Cell Disease" (132:396-398, 1978), concluded in part that "an absolute band count greater than 1,000/μL suggests bacterial infection in children with sickle cell anemia." They found such a level in 14 of 16 episodes of bacterial infection but in only ...
C, Pegelow, D, Powars, G D, Overturf
openaire +2 more sources
Sir.—A recentJournalreport by Buchanan and Glader entitled, "Leukocyte Counts in Children With Sickle Cell Disease" (132:396-398, 1978), concluded in part that "an absolute band count greater than 1,000/μL suggests bacterial infection in children with sickle cell anemia." They found such a level in 14 of 16 episodes of bacterial infection but in only ...
C, Pegelow, D, Powars, G D, Overturf
openaire +2 more sources
JAMA, 2022
Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized by formation of long chains of hemoglobin when deoxygenated within capillary beds, resulting in sickle-shaped red blood cells, progressive multiorgan damage, and increased mortality. An estimated 300 000 infants are born annually worldwide with SCD.
Patricia L, Kavanagh +2 more
openaire +2 more sources
Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized by formation of long chains of hemoglobin when deoxygenated within capillary beds, resulting in sickle-shaped red blood cells, progressive multiorgan damage, and increased mortality. An estimated 300 000 infants are born annually worldwide with SCD.
Patricia L, Kavanagh +2 more
openaire +2 more sources
The nephropathy of sickle cell trait and sickle cell disease
Nature Reviews Nephrology, 2022Sickle cell syndromes, including sickle cell disease (SCD) and sickle cell trait, are associated with multiple kidney abnormalities. Young patients with SCD have elevated effective renal plasma flow and glomerular filtration rates, which decrease to normal ranges in young adulthood and subnormal levels with advancing age.
Kenneth I. Ataga +2 more
openaire +2 more sources
Pediatric Clinics of North America, 1996
The identification of genetic mutation that causes sickle cell disease 35 years ago has not yet led to a widely applicable, specific therapy that corrects the underlying abnormality of hemoglobin. Nevertheless, recent progress in understanding the pathophysiology and natural history of sickling disorders has led directly to important prophylactic and ...
openaire +2 more sources
The identification of genetic mutation that causes sickle cell disease 35 years ago has not yet led to a widely applicable, specific therapy that corrects the underlying abnormality of hemoglobin. Nevertheless, recent progress in understanding the pathophysiology and natural history of sickling disorders has led directly to important prophylactic and ...
openaire +2 more sources
THE SICKLE CELL DISEASES IN PREGNANCY
Obstetrical & Gynecological Survey, 1959Abstract 1. 1. Prenatal patients are screened for the sickle cell diseases by sickling preparations, followed by hemoglobin electrophoresis and alkali denaturation if sickling is positive. 2. 2. Six patients with sickle cell disease and three with sickle cell-C disease are reported. 3. 3.
J, ABRAMS, I R, SCHWARTZ
openaire +2 more sources