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Annals of Internal Medicine, 2021
Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point mutation that leads to the production of hemoglobin S. Sickle cell disease is associated with hemolytic anemia, significant chronic end-organ damage, and early death. In high-
Lydia H, Pecker, Sophie, Lanzkron
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Sickle cell disease is an umbrella term for a group of hemoglobinopathies characterized by the presence of 2 β-globin gene mutations or deletions, at least 1 of which is the point mutation that leads to the production of hemoglobin S. Sickle cell disease is associated with hemolytic anemia, significant chronic end-organ damage, and early death. In high-
Lydia H, Pecker, Sophie, Lanzkron
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Nursing Standard, 2016
Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
Linda S. Overholser +2 more
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Essential facts Sickle cell disease is a group of disorders of red blood cells that is believed to affect up to 15,000 people in the UK. The lifelong condition can have a significant impact on morbidity and mortality.
Linda S. Overholser +2 more
+6 more sources
JAMA, 2022
Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized by formation of long chains of hemoglobin when deoxygenated within capillary beds, resulting in sickle-shaped red blood cells, progressive multiorgan damage, and increased mortality. An estimated 300 000 infants are born annually worldwide with SCD.
Patricia L, Kavanagh +2 more
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Sickle cell disease (SCD) is an inherited disorder of hemoglobin, characterized by formation of long chains of hemoglobin when deoxygenated within capillary beds, resulting in sickle-shaped red blood cells, progressive multiorgan damage, and increased mortality. An estimated 300 000 infants are born annually worldwide with SCD.
Patricia L, Kavanagh +2 more
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Archives of Pediatrics & Adolescent Medicine, 1979
Sir.—A recentJournalreport by Buchanan and Glader entitled, "Leukocyte Counts in Children With Sickle Cell Disease" (132:396-398, 1978), concluded in part that "an absolute band count greater than 1,000/μL suggests bacterial infection in children with sickle cell anemia." They found such a level in 14 of 16 episodes of bacterial infection but in only ...
C, Pegelow, D, Powars, G D, Overturf
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Sir.—A recentJournalreport by Buchanan and Glader entitled, "Leukocyte Counts in Children With Sickle Cell Disease" (132:396-398, 1978), concluded in part that "an absolute band count greater than 1,000/μL suggests bacterial infection in children with sickle cell anemia." They found such a level in 14 of 16 episodes of bacterial infection but in only ...
C, Pegelow, D, Powars, G D, Overturf
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Pediatric Clinics of North America, 2002
Sickle cell disease is a serious and life threatening disease that affects approximately 1 in 600 African-Americans. Since its first description in 1910 by Herrick, our understanding and treatment of this disease has grown tremendously. Most pediatricians will encounter one or more children with sickle cell disease and should have a thorough ...
Jason, Fixler, Lori, Styles
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Sickle cell disease is a serious and life threatening disease that affects approximately 1 in 600 African-Americans. Since its first description in 1910 by Herrick, our understanding and treatment of this disease has grown tremendously. Most pediatricians will encounter one or more children with sickle cell disease and should have a thorough ...
Jason, Fixler, Lori, Styles
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Hematology/Oncology Clinics of North America, 2005
The sickling disorders are a group of inherited diseases of the hemoglobin molecule characterized by chronic hemolytic anemia, increased susceptibility to infection, intermittent acute ‘crises,’ and progressive organ dysfunction as a result of vasoocclusion by the sickle erythrocytes.
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The sickling disorders are a group of inherited diseases of the hemoglobin molecule characterized by chronic hemolytic anemia, increased susceptibility to infection, intermittent acute ‘crises,’ and progressive organ dysfunction as a result of vasoocclusion by the sickle erythrocytes.
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Pediatric Clinics of North America, 1996
The identification of genetic mutation that causes sickle cell disease 35 years ago has not yet led to a widely applicable, specific therapy that corrects the underlying abnormality of hemoglobin. Nevertheless, recent progress in understanding the pathophysiology and natural history of sickling disorders has led directly to important prophylactic and ...
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The identification of genetic mutation that causes sickle cell disease 35 years ago has not yet led to a widely applicable, specific therapy that corrects the underlying abnormality of hemoglobin. Nevertheless, recent progress in understanding the pathophysiology and natural history of sickling disorders has led directly to important prophylactic and ...
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2015
People with sickle cell disease, a chronic hemolytic anemia, present with a wide variety of neurological syndromes, including ischemic and hemorrhagic stroke, anterior and posterior territory transient ischemic attacks (TIAs), "soft neurological signs," seizures, headache, coma, visual loss, and altered mental status.
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People with sickle cell disease, a chronic hemolytic anemia, present with a wide variety of neurological syndromes, including ischemic and hemorrhagic stroke, anterior and posterior territory transient ischemic attacks (TIAs), "soft neurological signs," seizures, headache, coma, visual loss, and altered mental status.
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Archives of Ophthalmology, 1985
To the Editor. —The article by Garty et al 1 in the OctoberArchivespresented the case reports of two children in whom sickle cell vaso-occlusive crisis was associated with periorbital swelling and frontal and orbital bone infarction. The relative infrequency of these findings in patients with sickle cell makes the article an important addition to our ...
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To the Editor. —The article by Garty et al 1 in the OctoberArchivespresented the case reports of two children in whom sickle cell vaso-occlusive crisis was associated with periorbital swelling and frontal and orbital bone infarction. The relative infrequency of these findings in patients with sickle cell makes the article an important addition to our ...
openaire +2 more sources