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Hematology/Oncology Clinics of North America, 2005
The sickling disorders are a group of inherited diseases of the hemoglobin molecule characterized by chronic hemolytic anemia, increased susceptibility to infection, intermittent acute ‘crises,’ and progressive organ dysfunction as a result of vasoocclusion by the sickle erythrocytes.
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The sickling disorders are a group of inherited diseases of the hemoglobin molecule characterized by chronic hemolytic anemia, increased susceptibility to infection, intermittent acute ‘crises,’ and progressive organ dysfunction as a result of vasoocclusion by the sickle erythrocytes.
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Enuresis in Sickle Cell Disease
The Journal of Urology, 1995The prevalence of enuresis and management options for this condition were studied in our population of sickle cell patients. A total of 91 active patients (6 to 21 years old) followed at our regional sickle cell center was surveyed for the symptoms of primary nocturnal enuresis. Of the 91 patients 27 (29.6%) had primary nocturnal enuresis.
T E, Figueroa +3 more
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2015
People with sickle cell disease, a chronic hemolytic anemia, present with a wide variety of neurological syndromes, including ischemic and hemorrhagic stroke, anterior and posterior territory transient ischemic attacks (TIAs), "soft neurological signs," seizures, headache, coma, visual loss, and altered mental status.
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People with sickle cell disease, a chronic hemolytic anemia, present with a wide variety of neurological syndromes, including ischemic and hemorrhagic stroke, anterior and posterior territory transient ischemic attacks (TIAs), "soft neurological signs," seizures, headache, coma, visual loss, and altered mental status.
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The spine in sickle cell disease
International Orthopaedics, 1994Bone changes in sickle cell disease occur due to marrow hyperplasia, tissue ischaemia and infarction due to vaso-occlusion. Between 1982 and 1991 thirty four patients were treated in the Orthopaedic and Neurosurgery Departments of the Kind Fahd University Hospital, Al-Khobar, with spinal complications due to sickle cell disease. There were 21 males and
M, Sadat-Ali +3 more
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Sickle Cell Disease and the Kidney
Seminars in Nephrology, 2003Sickle cell disease (SCD) affects the kidney by acute mechanisms, as a form of the sickle crisis, and insidiously with renal medullary/papillary necrosis, with resulting tubular defects. Glomerular hyperperfusion and hypertrophy results in a chronic sickle cell nephropathy that results in a significant morbidity in the progression to end-stage kidney ...
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Management of sickle cell disease
BMJ, 2008Hypoxia, hemolysis and infection are more or less associated in patients affected with sickle cell disease. Treatment is based on a programme including regular lifestyle, hydration, folic acid supply, prevention of pneumococcal infections and cerebrovascular events in children, regular follow-up in specialised centres allowing precocious screening and ...
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Fetal Hemoglobin, Sickling, and Sickle Cell Disease
Advances in Pediatrics, 1990Increased numbers of F cells and large amounts of Hb F/F cell appear to produce clinical benefit in rare variants of sickle cell disease and probably in more commonly encountered patients. Fetal hemoglobin interferes with polymerization of Hb S in vitro, but laboratory studies carried out with homogeneous hemoglobin solutions are inadequate models of ...
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Hydroxyurea for sickle cell disease
2001Sickle cell disease is one of the most common inherited diseases world wide. It is associated with life long morbidity and a reduced life expectancy. Hydroxyurea, a chemotherapeutic drug taken by mouth, raises fetal haemoglobin and, as such, is expected to ameliorate some of the clinical problems of sickle cell disease.To assess the effects of ...
Ashley P Jones +2 more
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