Results 21 to 30 of about 1,827,024 (396)

Techniques for the Detection of Sickle Cell Disease: A Review

Micromachines, 2021
Sickle cell disease (SCD) is a widespread disease caused by a mutation in the beta-globin gene that leads to the production of abnormal hemoglobin called hemoglobin S.
W. Arishi, H. Alhadrami, M. Zourob
semanticscholar   +1 more source

Treatment of sickle cell disease by increasing oxygen affinity of hemoglobin.

Blood, 2021
The issue of treating sickle cell disease with drugs that increase hemoglobin oxygen affinity has come to the fore with the FDA approval in 2019 of voxelotor, the only anti-sickling drug approved since hydroxyurea in 1998.
E. Henry, B. Metaferia, Quan Li, Julia Harper, R. Best, Kristen E. Glass, Troy Cellmer, Emily B. Dunkelberger, Anna K. Conrey, S. Thein, H. Bunn, W. Eaton   +11 more
semanticscholar   +1 more source

HIV-1 Tat phosphorylation on Ser-16 residue modulates HIV-1 transcription

Retrovirology, 2018
Background HIV-1 transcription activator protein Tat is phosphorylated in vitro by CDK2 and DNA-PK on Ser-16 residue and by PKR on Tat Ser-46 residue. Here we analyzed Tat phosphorylation in cultured cells and its functionality. Results Mass spectrometry
Andrey Ivanov, Xionghao Lin, Tatiana Ammosova, Andrey V. Ilatovskiy, Namita Kumari, Hatajai Lassiter, Nowah Afangbedji, Xiaomei Niu, Michael G. Petukhov, Sergei Nekhai   +9 more
doaj   +1 more source

Mortality in sickle cell disease. Life expectancy and risk factors for early death.

New England Journal of Medicine, 1994
BACKGROUND Information on life expectancy and risk factors for early death among patients with sickle cell disease (sickle cell anemia, sickle cell-hemoglobin C disease, and the sickle cell-beta-thalassemias) is needed to counsel patients, target therapy,
O. Platt, D. Brambilla, W. Rosse, P. Milner, O. Castro, M. Steinberg, P. Klug   +6 more
semanticscholar   +1 more source

Conjugate Haemophilus influenzae type b vaccines for sickle cell disease. [PDF]

, 2016
BACKGROUND: People affected with sickle cell disease are at high risk of infection from Haemophilus influenzae type b. Before the implementation of Haemophilus influenzae type b conjugate vaccination in high-income countries, this was responsible for a ...
Allali, Slimane, Ballas, Samir K., Chalumeau, Martin, de Montalembert, Mariane, Launay, Odile   +4 more
core   +2 more sources

Protein Phosphatase-1 Regulates Expression of Neuregulin-1

Biology, 2016
Protein phosphatase 1 (PP1), a cellular serine/threonine phosphatase, is targeted to cellular promoters by its major regulatory subunits, PP1 nuclear targeting subunit, nuclear inhibitor of PP1 (NIPP1) and RepoMan.
Tatiana Ammosova, Kareem Washington, Jamie Rotimi, Namita Kumari, Kahli A. Smith, Xiaomei Niu, Marina Jerebtsova, Sergei Nekhai   +7 more
doaj   +1 more source

Successful orthotopic liver transplantation in an adult patient with sickle cell disease and review of the literature [PDF]

, 2013
Sickle cell disease can lead to hepatic complications ranging from acute hepatic crises to chronic liver disease including intrahepatic cholestasis, and iron overload.
Blinder, Morey A., Chapman, William, Crippin, Jeffrey S., Field, Joshua J., Geng, B., Korenblat, Kevin, Lisker-Melman, Mauricio, Shenoy, Shalini   +7 more
core   +2 more sources

Post-Transcriptional Genetic Silencing of BCL11A to Treat Sickle Cell Disease.

New England Journal of Medicine, 2020
BACKGROUND Sickle cell disease is characterized by hemolytic anemia, pain, and progressive organ damage. A high level of erythrocyte fetal hemoglobin (HbF) comprising α- and γ-globins may ameliorate these manifestations by mitigating sickle hemoglobin ...
Erica B Esrick, L. Lehmann, A. Biffi, Maureen Achebe, C. Brendel, M. Ciuculescu, H. Daley, B. Mackinnon, Emily Morris, Amy Federico, D. Abriss, K. Boardman, R. Khelladi, K. Shaw, H. Negre, O. Nègre, S. Nikiforow, J. Ritz, S. Pai, W. London, C. Dansereau, M. Heeney, M. Armant, J. Manis, David A. Williams   +24 more
semanticscholar   +1 more source

Red cell transfusion and alloimmunization in sickle cell disease

Haematologica, 2021
Red cell transfusion remains a critical component of care for acute and chronic complications of sickle cell disease. Randomized clinical trials demonstrated the benefits of transfusion therapy for prevention of primary and secondary strokes and ...
G. Linder, S. Chou
semanticscholar   +1 more source

Incidence, kinetics, and risk factors for intra- and extracranial cerebral arteriopathies in a newborn sickle cell disease cohort early assessed by transcranial and cervical color Doppler ultrasound

Frontiers in Neurology, 2022
The risk of stroke in children with sickle cell disease (SCD) is detected by abnormal intracranial arterial time-averaged mean of maximum velocities (TAMVs ≥200 cm/s).
Françoise Bernaudin, Françoise Bernaudin, Cécile Arnaud, Annie Kamdem, Isabelle Hau, Fouad Madhi, Camille Jung, Ralph Epaud, Suzanne Verlhac   +8 more
doaj   +1 more source