Results 21 to 30 of about 94,881 (302)

The Neonatal Screening Program in Brazil, Focus on Sickle Cell Disease (SCD)

International Journal of Neonatal Screening, 2019
Since 2001, the Brazilian Ministry of Health has been coordinating a National Neonatal Screening Program (NNSP) that now covers all the 26 states and the Federal District of the Brazilian Republic and targets six diseases including sickle cell disease ...
Ana C. Silva-Pinto, Maria Cândida Alencar de Queiroz, Paula Juliana Antoniazzo Zamaro, Miranete Arruda, Helena Pimentel dos Santos   +4 more
doaj   +1 more source

Osteoporosis in thalassaemia

Thalassemia Reports, 2018
Osteoporosis is a prominent cause of morbidity in patients with thalassaemia major (TM) with a complex pathophysiology. Patients with TM and osteoporosis have elevated markers of bone resorption.
Ersi Voskaridou, Maria Dimopoulou, Evangelos Terpos   +2 more
doaj   +1 more source

The patient as a partner in promoting healthcare policies and research

Thalassemia Reports, 2014
Not ...
Marco Bianchi, on behalf of Thalassaemia International Federation   +1 more
doaj   +1 more source

RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice

Haematologica, 2018
Sickle cell disease patients are at increased risk of developing a chronic kidney disease. Endothelial dysfunction and inflammation associated with hemolysis lead to vasculopathy and contribute to the development of renal disease.
Alfia Khaibullina, Elena A. Adjei, Nowah Afangbedji, Andrey Ivanov, Namita Kumari, Luis E.F. Almeida, Zenaide M.N. Quezado, Sergei Nekhai, Marina Jerebtsova   +8 more
doaj   +1 more source

Barriers to Therapeutic Use of Hydroxyurea for Sickle Cell Disease in Nigeria: A Cross-Sectional Survey

Frontiers in Genetics, 2022
Background: Sickle cell disease, the inherited blood disorder characterized by anemia, severe pain and other vaso-occlusive complications, acute chest syndrome, disproportionate hospitalization, and early mortality, has significant financial, social, and
Emmanuel Chide Okocha, Joyce Gyamfi, Nessa Ryan, Oluwatoyin Babalola, Eno-Abasi Etuk, Reuben Chianumba, Maxwell Nwegbu, Hezekiah Isa, Anazoeze Jude Madu, Samuel Adegoke, Uche Nnebe-Agumandu, Biobele Brown, Emmanuel Peprah, Obiageli E. Nnodu   +13 more
doaj   +1 more source

Calibrating Sickle Cell Disease [PDF]

Biophysical Journal, 2016
Sickle cell disease is fundamentally a kinetic disorder, in which cells containing the mutated hemoglobin (hemoglobin S; HbS) will cause occlusion if they sickle in the microvasculature, but have minimal (or no) consequences if they sickle in the venous return.
Donna Yosmanovich, Maria Rotter, Alexey Aprelev, Frank A. Ferrone   +3 more
openaire   +2 more sources

Transition Readiness of Pediatric Sickle Cell Patients to Adult Clinic in a Teaching Hospital, Ghana

Advances in Hematology
Conclusion: The study revealed a high transition readiness among pediatric patients. In general, the patients had high confidence transitioning to an adult clinic and the ability to manage their own healthcare.
Aaron Kwasi Nartey, Vivian Paintsil, Isaac Nyanor, Yaa Gyamfua Oppong-Mensah, Evans Xorse Amuzu, Eunice Agyeman Ahmed, Suraj Yawnumah Abubakar, Alex Osei-Akoto   +7 more
doaj   +1 more source

Personalizing the Pediatric Hematology/Oncology Fellowship: Adapting Training for the Next Generation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT The pediatric hematology‐oncology fellowship training curriculum has not substantially changed since its inception. The first year of training is clinically focused, and the second and third years are devoted to scholarship. However, this current structure leaves many fellows less competitive in the current job market, resulting in ...
Scott C. Borinstein, Melissa J. Rose, Scott Moerdler, Richard Ho   +3 more
wiley   +1 more source

Antiviral response and HIV-1 inhibition in sickle cell disease

iScience
Summary: Sickle cell disease (SCD) is characterized by hemolysis, vaso-occlusion, and ischemia. HIV-1 infection was previously shown to be suppressed in SCD PBMCs.
Namita Kumari, Asrar Ahmad, Clemilson Berto-Junior, Andrey Ivanov, Fayuan Wen, Xionghao Lin, Sharmin Diaz, Iheanyi Okpala, James G. Taylor, VI, Marina Jerebtsova, Sergei Nekhai   +10 more
doaj   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source