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Coronavirus Disease among Persons with Sickle Cell Disease, United States, March 20–May 21, 2020
Emerging Infectious Diseases, 2020 Sickle cell disease (SCD) disproportionately affects Black or African American persons in the United States and can cause multisystem organ damage and reduced lifespan.
J. Panepinto +9 more
semanticscholar +1 more source
Leg ulcers in sickle cell disease. [PDF]
, 2010 Sickle cell disease is a single amino acid molecular disorder of hemoglobin leading to its pathological polymerization, red cell rigidity that causes poor microvascular blood flow, with consequent tissue ischemia and infarction.
Ballas, Samir K. +4 more
core +2 more sources
A Phase 3 Randomized Trial of Voxelotor in Sickle Cell Disease.
New England Journal of Medicine, 2019 BACKGROUND Deoxygenated sickle hemoglobin (HbS) polymerization drives the pathophysiology of sickle cell disease. Therefore, direct inhibition of HbS polymerization has potential to favorably modify disease outcomes.
E. Vichinsky +21 more
semanticscholar +1 more source
When Actions Speak Louder Than Words - Racism and Sickle Cell Disease.
New England Journal of Medicine, 2020 Racism and Sickle Cell Disease As medical leaders around the United States issue statements denouncing racial injustice and calling for the dismantling of racism, we must ensure that these pledges ...
A. Power-Hays, Patrick T McGann
semanticscholar +1 more source
The Lancet, 2004 With the global scope of sickle-cell disease, knowledge of the countless clinical presentations and treatment of this disorder need to be familiar to generalists, haematologists, internists, and paediatricians alike. Additionally, an underlying grasp of sickle-cell pathophysiology, which has rapidly accrued new knowledge in areas related to erythrocyte
Ronald L. Nagel, Marie J. Stuart
openaire +6 more sources
The Neonatal Screening Program in Brazil, Focus on Sickle Cell Disease (SCD)
International Journal of Neonatal Screening, 2019 Since 2001, the Brazilian Ministry of Health has been coordinating a National Neonatal Screening Program (NNSP) that now covers all the 26 states and the Federal District of the Brazilian Republic and targets six diseases including sickle cell disease ...
Ana C. Silva-Pinto +4 more
doaj +1 more source
Fatal Dengue in Patients with Sickle Cell Disease or Sickle Cell Anemia in Curaçao: Two Case Reports [PDF]
, 2013 Fatal Dengue in Patients with Sickle Cell Disease or Sickle Cell Anemia in Curaçao: Two Case ...
ACE Andrianarisoa +17 more
core +5 more sources
Pathophysiology of Sickle Cell Disease.
Annual Review of Pathology, 2019 Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made in the elucidation of the pathogenesis of its protean complications, which has inspired recent advances in targeted molecular therapies. In SCD, a single amino acid
P. Sundd, M. Gladwin, E. Novelli
semanticscholar +1 more source
COVID‐19 infection in patients with sickle cell disease
British Journal of Haematology, 2020 Severe acute respiratory syndrome coronavirus 2, also known as COVID-19, has spread to 184 countries with almost 1.5 million cases as of mid-April 2020 since first reported (1). The clinical features of this disease are not completely understood, however
F. Hussain +5 more
semanticscholar +1 more source
Thalassemia Reports, 2018 Osteoporosis is a prominent cause of morbidity in patients with thalassaemia major (TM) with a complex pathophysiology. Patients with TM and osteoporosis have elevated markers of bone resorption.
Ersi Voskaridou +2 more
doaj +1 more source