Results 51 to 60 of about 178,306 (248)

Nasopharyngeal carriage rate of Streptococcus pneumoniae in Ugandan children with Sickle Cell Disease [PDF]

, 2012
BackgroundNasopharyngeal carriage ofStreptococcus pneumoniaeis a determinant for invasive pneumococcal disease, which often complicates homozygous sickle cell disease. Here, we determined the nasopharyngeal carriage rate ofS.
David P Kateete, Henry Kajumbula, Deogratias H Kaddu-Mulindwa, Augustine K Ssevviri   +3 more
core   +2 more sources

Stroke without cerebral arteriopathy in sickle cell disease children: causes and treatment

Haematologica
Cerebral arteriopathy (CA) in children with sickle cell disease (SCD) is classically described as chronic stenosis of arteries in the anterior brain circulation, leading to ischemic stroke. Some studies have however reported strokes in children with SCD
Sarah Liane Linguet, Suzanne Verlhac, Florence Missud, Laurent Holvoet-Vermaut, Valentine Brousse, Ghislaine Ithier, Alexandra Ntorkou, Emmanuelle Lesprit, Malika Benkerrou, Manoëlle Kossorotoff, Berengere Koehl   +10 more
doaj   +1 more source

Sickle Cell Disease

Transfusion Medicine and Hemotherapy
Background: Sickle cell disease (SCD) is among the most frequent hereditary disorders globally and its prevalence in Europe is increasing due to migration movements. Summary: The basic pathophysiological event of SCD is polymerization of deoxygenated sickle hemoglobin, resulting in hemolysis, vasoocclusion, and multiorgan damage.
Kunz, Joachim B., Tagliaferri, Laura
openaire   +2 more sources

Macrophage HIV-1 Gene Expression and Delay Resolution of Inflammation in HIV-Tg Mice

Viruses, 2020
While antiretroviral therapy increases the longevity of people living with HIV (PLWH), about 30% of this population suffers from three or more concurrent comorbidities, whose mechanisms are not well understood.
Marina Jerebtsova, Asrar Ahmad, Namita Kumari, Ornela Rutagarama, Sergei Nekhai   +4 more
doaj   +1 more source

Use of Complementary and Alternative Medicine for Children with Sickle Cell Disease: Prevalence and Factors Associated with Use [PDF]

, 2021
Mohammed Alsabri, Kusum Viswanathan, Fiorella Castillo, P. Ghai, Maryam Hemmat Hamrah   +4 more
openalex   +1 more source

Sickle Cell Disease Complications [PDF]

Thalassemia Reports, 2014
Sickle cell disease (SCD) is an inherited, lifelong condition. The sickle mutation consists a single nucleotide change (GAT->GTT) in the sixth codon of exon 1 of the β-globin gene coding for the β-globin polypeptide of hemoglobin (Hb) (a2β2). This change results in replacement of the wild type glutamic acid residue by a valine residue in β-globin ...
openaire   +2 more sources

Clinical manifestations of sickle cell disease in Africa and its association with foetal haemoglobin parameters

Communications Medicine
Background Prevalence of sickle cell disease (SCD) across African countries ranges between 1–3% and contributes up to 7–16% of under-five mortality.
Evans Xorse Amuzu, Florence Urio, Elliot Eli Dogbe, Peter Ponsian, Suraj Yawnumah Abubakar, Chinedu Okeke, Olasinbo Olumuyiwa Balogun, Petronilla Jean Ozumba, Alex Osei-Akoto, Vivian Paintsil, Obiageli Nnodu, Emmanuel Balandya, Julie Makani, Madu Anazoeze, Daniel Ansong, Siana Nkya   +15 more
doaj   +1 more source

Barriers to Pediatric Sickle Cell Disease Guideline Recommendations. [PDF]

, 2019
National guidelines recommend that providers counsel all patients with sickle cell anemia about hydroxyurea (HU) therapy and screen children with sickle cell anemia annually for the risk of stroke with transcranial Doppler (TCD).
Bardach, Naomi S, Cabana, Michael D, Kanter, Julie, Marsh, Anne M, Rowland, Michael, Stemmler, Peggy, Treadwell, Marsha J   +6 more
core  

Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1. [PDF]

, 2015
Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during ...
Chakravorty, Subarna, Cunnington, Aubrey J, De La Fuente, Josu, Evans, Ceri, Horvath, Erzsebet, Levin, Michael, Orf, Katharine   +6 more
core   +4 more sources

Randomized phase 2 trial of regadenoson for treatment of acute vaso-occlusive crises in sickle cell disease [PDF]

, 2017
Key Points Regadenoson did not reduce iNKT cell activation to a prespecified level when administered to patients with SCD. Because iNKT cell activation was not reduced, the benefit of iNKT cell-based therapies in SCD cannot be determined.
Achebe, Maureen, Chu, Hillary, Field, Joshua J., George, Alex, Gordeuk, Victor R., Gowhari, Michel, Heeney, Matthew M., Hoppe, Carolyn, Lin, Gene, Linden, Joel, Majerus, Elaine, Nathan, David G., Neuberg, Donna, Puligandla, Maneka, Sheehan, Brian   +14 more
core   +2 more sources