Results 51 to 60 of about 70,815 (255)

SICKLE CELL DISEASE AND PREGNANCY

Mediterranean Journal of Hematology and Infectious Diseases, 2019
Abstract   Sickle Cell Disease (SCD) is a group of inherited single-gene autosomal recessive disorders caused by the ‘sickle’ gene, which affects haemoglobin structure. Sickle cell anemia is the most common hemoglobinopathy worldwide. The burden of sickle cell disease in pregnancy has been exponentially increasing with more number of women reaching ...
Dipty Jain, Pooja Lodha, Roshan Colah, Prachi Atmapoojya, Prachi Atmapoojya   +4 more
openaire   +4 more sources

Unveiling Extramedullary Hematopoiesis: A Case Report Highlighting the Causes, Symptoms, and Management Strategies

Thalassemia Reports
Extramedullary hematopoiesis (EMH) serves as a compensatory mechanism in chronic hemolytic anemias, such as thalassemia, and can result in spinal cord compression.
Konstantinos Manganas, Aikaterini Xydaki, Angeliki Kotsiafti, Olympia Papakonstantinou, Sophia Delicou   +4 more
doaj   +1 more source

Thrombosis and Sickle Cell Disease

Seminars in Thrombosis and Hemostasis, 2011
Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin, which has the unique property of polymerizing when deoxygenated. The pathophysiology of acute and chronic clinical manifestations of SCD have shown the central role of dense, dehydrated red cells in acute and chronic clinical manifestations of this pathology.
DE FRANCESCHI, Lucia, Cappellini MD, OLIVIERI, Oliviero   +2 more
openaire   +2 more sources

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Early detection and management of extracranial arteriopathy reduces the incidence of silent cerebral infarcts in sickle cell anemia: a long-term prospective cohort study

Haematologica
Previous reports about the Creteil newborn-cohort (1988/Apr-2007) showed that the risk of silent cerebral infarcts (SCI) remained high (37.1%) by age 14 in children with sickle cell anemia (SCA) and intracranial time-averaged mean maximum velocity ...
Francoise Bernaudin, Cecile Arnaud, Annie Kamdem, Jenny Youn, Manuela Vasile, Isabelle Hau, Fouad Madhi, Aline Malterre, Celine Delestrain, Ralph Epaud, Camille Jung, Suzanne Verlhac   +11 more
doaj   +1 more source

Newborn Screening for Sickle Cell Disease in the Caribbean: An Update of the Present Situation and of the Disease Prevalence

International Journal of Neonatal Screening, 2019
The region surrounding the Caribbean Sea is predominantly composed of island nations for its Eastern part and the American continental coast on its Western part.
Jennifer Knight-Madden, Ketty Lee, Gisèle Elana, Narcisse Elenga, Beatriz Marcheco-Teruel, Ngozi Keshi, Maryse Etienne-Julan, Lesley King, Monika Asnani, Marc Romana, Marie-Dominique Hardy-Dessources   +10 more
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

Delayed hemolytic transfusion reaction in children with sickle cell disease: first 5-year retrospective study in mainland France

Haematologica, 2022
Claire Falguière, Slimane Allali, Bassem Khazem, Annie Kamdem, Cécile Arnaud, Marie Belloy, Corinne Guitton, Marie-Hélène Odièvre, Sophie Pertuisel, Cecile Dumesnil, Cécile Guillaumat, Nathalie Garrec, Alexandra Gauthier, Perrine Mahe, Valerie Soussan-Banini, Laure Le-Carrer, Etienne Merlin, Audrey David, Beatrice Pellegrino, Catherine Paillard, Jean-Francois Brasme, Marie Lagarde, France Pirenne, Corinne Pondarre   +23 more
doaj   +1 more source

Evaluating the (comparative) safety profile of the novel oral polio vaccine type 2 using individual case safety reports in VigiBase

British Journal of Clinical Pharmacology, EarlyView.
Aim Novel oral polio vaccine type 2 (nOPV2) was used under the WHO emergency use listing for circulating vaccine‐derived polio virus (cVDPV) outbreaks from 2021 to 2023. We assessed nOPV2 adverse events following immunization (AEFIs) and compared its safety profile to other vaccines using VigiBase.
Comfort Kunak Ogar, Malede Mequanent Sisay, Leonardo Roque‐Pereira, Christine Leopold, Patrick C. Souverein, Aukje K. Mantel‐Teeuwisse, Marie L. De Bruin   +6 more
wiley   +1 more source

Family cord blood banking for sickle cell disease: a twenty-year experience in two dedicated public cord blood banks

Haematologica, 2017
Efforts to implement family cord blood banking have been developed in the past decades for siblings requiring stem cell transplantation for conditions such as sickle cell disease. However, public banks are faced with challenging decisions about the units
Hanadi Rafii, Françoise Bernaudin, Helene Rouard, Valérie Vanneaux, Annalisa Ruggeri, Marina Cavazzana, Valerie Gauthereau, Aurélie Stanislas, Malika Benkerrou, Mariane De Montalembert, Christele Ferry, Robert Girot, Cecile Arnaud, Annie Kamdem, Joelle Gour, Claudine Touboul, Audrey Cras, Mathieu Kuentz, Claire Rieux, Fernanda Volt, Barbara Cappelli, Karina T. Maio, Annalisa Paviglianiti, Chantal Kenzey, Jerome Larghero, Eliane Gluckman   +25 more
doaj   +1 more source