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Frontiers in Genetics, 2022 Background: Sickle cell disease, the inherited blood disorder characterized by anemia, severe pain and other vaso-occlusive complications, acute chest syndrome, disproportionate hospitalization, and early mortality, has significant financial, social, and
Emmanuel Chide Okocha +13 more
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Global, regional, and national prevalence and mortality burden of sickle cell disease, 2000-2021: a systematic analysis from the Global Burden of Disease Study 2021. [PDF]
BACKGROUND: Previous global analyses, with known underdiagnosis and single cause per death attribution systems, provide only a small insight into the suspected high population health effect of sickle cell disease.
GBD 2021 Sickle Cell Disease Collaborators,
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Of pools, oceans, and the Dead Sea. [PDF]
, 2017 In a comprehensive study in this issue of Blood, Carden and colleagues describe the importance of the tonicity of IV fluids used in the treatment of patients with sickle cell disease (SCD) during vaso-occlusive crises (VOCs).
Ballas, Samir K.
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The Red Blood Cell—Inflammation Vicious Circle in Sickle Cell Disease
Frontiers in Immunology, 2020 Sickle cell disease (SCD) is a genetic disease caused by a single mutation in the β-globin gene, leading to the production of an abnormal hemoglobin called hemoglobin S (HbS), which polymerizes under deoxygenation, and induces the sickling of red blood ...
E. Nader, M. Romana, P. Connes
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The patient as a partner in promoting healthcare policies and research
Thalassemia Reports, 2014 Not ...
Marco Bianchi +1 more
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Elevated pulse pressure is associated with hemolysis, proteinuria and chronic kidney disease in sickle cell disease [PDF]
, 2014 A seeming paradox of sickle cell disease is that patients do not suffer from a high prevalence of systemic hypertension in spite of endothelial dysfunction, chronic inflammation and vasculopathy.
Gladwin, MT +6 more
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, 2020 Sickle cell disease is characterized by vaso-occlusive and hemolysis events that may occur in a variable range of clinical presentations. Patients with this disease, particularly with acute chest syndrome, suffer acute episodes of chest pain caused by vaso-occlusive crisis, that tend to repeat, especially under the influence of lower respiratory ...
Ofelia A. Alvarez +1 more
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RON kinase inhibition reduces renal endothelial injury in sickle cell disease mice
Haematologica, 2018 Sickle cell disease patients are at increased risk of developing a chronic kidney disease. Endothelial dysfunction and inflammation associated with hemolysis lead to vasculopathy and contribute to the development of renal disease.
Alfia Khaibullina +8 more
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A Phase 3 Trial of l‐Glutamine in Sickle Cell Disease
New England Journal of Medicine, 2018 BACKGROUND Oxidative stress contributes to the complex pathophysiology of sickle cell disease. Oral therapy with pharmaceutical‐grade l‐glutamine (USAN, glutamine) has been shown to increase the proportion of the reduced form of nicotinamide adenine ...
Y. Niihara +22 more
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Comorbidities in aging patients with sickle cell disease. [PDF]
, 2018 Sickle cell disease (SCD) in general and sickle cell anemia in particular is a highly complex disorder both at the molecular and clinical levels. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing ...
Ballas, Samir K.
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