Results 71 to 80 of about 1,827,024 (396)

The glomerulopathy of sickle cell disease [PDF]

American Journal of Hematology, 2014
Sickle cell disease (SCD) produces many structural and functional abnormalities in the kidney, including glomerular abnormalities. Albuminuria is the most common manifestation of glomerular damage, with a prevalence between 26 and 68% in adult patients.
David R. Archer, Vimal K. Derebail, Kenneth I. Ataga   +2 more
openaire   +3 more sources

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

Red blood cell endothelial nitric oxide synthase: A major player in regulating cardiovascular health

British Journal of Pharmacology, EarlyView., 2023
Abstract Red blood cells (RBCs) have traditionally been seen as simple carriers of gases and nutrients in the body. One important non‐canonical function of RBCs in the cardiovascular system is the regulation of nitric oxide (NO) metabolism. It has been shown that RBCs can scavenge NO, transport NO metabolites and produce NO in hypoxic conditions ...
Anthea LoBue, Sophia K. Heuser, Marla Lindemann, Junjie Li, Masudur Rahman, Malte Kelm, Johannes Stegbauer, Miriam M. Cortese‐Krott   +7 more
wiley   +1 more source

Awareness, attitude, and acceptance of newborn screening for sickle cell disease among health workers and caregivers at primary healthcare centers in Gwagwalada Area Council, Federal Capital Territory, Abuja, Nigeria

Frontiers in Public Health
IntroductionNewborn Screening (NBS) is a public health program designed to identify and provide early interventions for infants with genetic disorders such as Sickle Cell Disease (SCD).
Isa Hezekiah A, Chisomaga Ifeanyi Oparaugo, Grace Doyin Ajetomobi, Ayomide Esther Fasina, Reuben Ikechukwu Chianumba, Obiageli Eunice Nnodu, Obiageli Eunice Nnodu   +6 more
doaj   +1 more source

Impairment of neutrophil oxidative burst in children with sickle cell disease is associated with heme oxygenase-1. [PDF]

, 2015
Sickle cell disease is a risk factor for invasive bacterial infections, and splenic dysfunction is believed to be the main underlying cause. We have previously shown that the liberation of heme in acute hemolysis can induce heme oxygenase-1 during ...
Chakravorty, Subarna, Cunnington, Aubrey J, De La Fuente, Josu, Evans, Ceri, Horvath, Erzsebet, Levin, Michael, Orf, Katharine   +6 more
core   +4 more sources

Sickle Cell Disease

Transfusion Medicine and Hemotherapy
Background: Sickle cell disease (SCD) is among the most frequent hereditary disorders globally and its prevalence in Europe is increasing due to migration movements. Summary: The basic pathophysiological event of SCD is polymerization of deoxygenated sickle hemoglobin, resulting in hemolysis, vasoocclusion, and multiorgan damage.
Kunz, Joachim B., Tagliaferri, Laura
openaire   +2 more sources

Asthma in Sickle Cell Disease [PDF]

The Scientific World JOURNAL, 2011
In recent years, evidence has increased that asthma predisposes to complications of sickle cell disease (SCD), such as pain crises, acute chest syndrome, pulmonary hypertension, and stroke, and is associated with increased mortality. An obstructive pattern of pulmonary function, along with a higher-than-expected prevalence of airway hyper ...
Manisha Newaskar, Karen A. Hardy, Claudia R. Morris   +2 more
openaire   +4 more sources

The feasibility of pharmacokinetic‐based dosing of hydroxyurea for children with sickle cell anaemia in Uganda: Baseline results of the alternative dosing and prevention of transfusions trial

British Journal of Clinical Pharmacology, EarlyView.
Abstract Pharmacokinetic (PK)‐guided dosing of hydroxyurea for children with sickle cell anaemia (SCA) could optimize dosing and improve outcomes, but its feasibility has not been demonstrated in low‐resource settings where the majority of affected children live.
Alexandra Power‐Hays, Ruth Namazzi, Min Dong, Caroline Kazinga, Charles Kato, Sadat Aliwuya, Kathryn McElhinney, Andrea L. Conroy, Adam Lane, Chandy John, Alexander A. Vinks, Teresa Latham, Robert O. Opoka, Russell E. Ware   +13 more
wiley   +2 more sources

Reaching Community Through School Going Children for Sickle Cell Disease in Zankhvav Village of Surat District, Western India [PDF]

, 2012
Objectives: The objective of the study was to explore a method to reach the community via school going adolescents for screening tribal people for Sickle Cell disease.
Bansal, R, Gharat, VV, Mallick, KH, Rupani, MP, Vasava, BC   +4 more
core   +1 more source

Cholecystectomy in sickle cell disease patients: Is there more acute chest syndrome after laparoscopy? A case controlled study [PDF]

, 2008
Laparoscopy is increasingly being recommended in order to reduce postoperative complications among sickle cell disease patients undergoing cholecystectomy. Acute chest syndrome is the most deadly of these complications.
Coulibaly, A., Diarra, B., Ehua Somian, F., Franco, D., Kanga-Miessan, J.-B., Roudié, J.   +5 more
core   +1 more source