Results 151 to 160 of about 204,284 (265)

Undetectable Hydroxyurea Levels in the Majority of Sickle Cell Disease Patients, Especially in Young Children

American Journal of Hematology, Volume 101, Issue 9, Page 2297-2310, September 2026.
ABSTRACT Hydroxyurea (HU) is the most widely prescribed disease‐modifying treatment in sickle cell disease (SCD), though treatment responses vary due to metabolism and adherence. We examined HU blood levels and treatment response in patients with homozygous sickle cell disease (HbSS).
Sigrid van der Veen, Bart J. Biemond, Marjon H. Cnossen, Pablo Bartolucci, Maria P. Boaro, Betzabel Cajiao Garcia, Raffaella Colombatti, M. D'Agnolo, Karin Fijnvandraat, Anna Collado Gimbert, Amira Idrizovic, Petros Kountouris, Mar Mañú‐Pereira, Elisabetta Mezzalira, Mariane de Montalembert, Erfan Nur, A. Pham Hung D' Alexandry D'Orengiani, Tiziana Sanavia, Saskia E. M. Schols, Marissa J. M. Traets, Minke A. E. Rab, Sara I. Reidel, Anita W. Rijneveld, Yosr Zaouali, Nanda M. Verhoeven‐Duif, Judith J. M. Jans, Eduard J. van Beers   +26 more
wiley   +1 more source

Histone Post‐Translational Modifications Regulating Ferroptosis: The Molecular Mechanisms and Disease Associations

Cell Biochemistry and Function, Volume 44, Issue 9, September 2026.
ABSTRACT Ferroptosis is a form of programmed cell death characterized by iron‐dependent phospholipid peroxidation and is implicated in a wide range of human diseases. Emerging evidence highlights the critical role of epigenetic regulation in this process.
Xiaoqian Tang, Haodang Luo, Siqi Gao, Xiaocheng Liu, Qing Sun, Yanhua Zeng   +5 more
wiley   +1 more source

Pyruvate kinase deficiency modifies sickle hemoglobin carrier and sickle cell disease phenotypes in mice. [PDF]

JCI Insight
Wang X, Smith M, Kamimura S, Li Q, Shah N, Quezado M, Almeida LE, Vogel S, Tegegn MB, Sun KY, Villasmil R, Liu C, Eaton WA, Thein SL, Quezado ZM.   +14 more
europepmc   +1 more source

Sickle Cell Data Collection Program Brief : Hospital Encounters Among Adults Living With Sickle Cell Disease in Georgia 2012-2016 [PDF]

The Georgia Sickle Cell Data Collection Program (SCDC) identified 5,405 adults living with sickle cell disease in Georgia from 2012 through 2016. Adults with sickle cell disease live in almost every county throughout Georgia.Nearly nine in 10 (88%) of ...

core  

Discovery of Osivelotor (GBT021601): A Potent, Next-Generation Sickle Hemoglobin Polymerization Inhibitor. [PDF]

ACS Med Chem Lett
Li Z, Alt C, Dufu K, Hutchaleelaha A, Xu Q, Zhang X, Li CM, Rademacher P, Bosmajian C, Pochron MP, Partridge JR, Oksenberg D, Cathers BE.   +12 more
europepmc   +1 more source

Detecting sickle hemoglobin. [PDF]

BMJ, 1972
openaire   +2 more sources

Small-molecule inhibitor screen to identify mechanisms of sickle hemoglobin clearance by liver endothelium. [PDF]

Blood Vessel Thromb Hemost
Kaminski TW, Zhang H, Katoch O, Shi Q, Kato GJ, Sundd P, Pradhan-Sundd T.   +6 more
europepmc   +1 more source

TTP‐Like Syndrome and Subsequent Non‐Aneurysmal Subarachnoid Hemorrhage in HbSC Disease: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Sickle cell disease (SCD) with hemoglobin‐ (Hb‐) SC genotype is often considered a milder SCD variant, yet life‐threatening complications can occur. A 26‐year‐old man with HbSC disease presented with an infection triggered vaso‐occlusive crisis (VOC), acute chest syndrome (ACS), severe thrombocytopenia, Coombs‐negative hemolysis with ...
Benjamin Vieten, Jan Vorwerk, Jan Morf, Alice Dauth, Stefan Sondermann, Peter Schramm, Tobias Graf, Nikolas von Bubnoff, Lorenz Oelschläger, Cyrus Khandanpour   +9 more
wiley   +1 more source

Sticking together: Polymerization of sickle hemoglobin drives the multiscale pathophysiology of sickle cell disease. [PDF]

Biophys Rev (Melville)
Williams DC, Szafraniec HM, Wood DK.
europepmc   +1 more source

Hydrocephalus and Diffuse Alveolar Hemorrhage as the Initial Manifestation of Systemic Lupus Erythematosus and Antiphospholipid Syndrome: A Case Report

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Systemic lupus erythematosus (SLE) is an autoimmune disease that can affect many systems, such as the central nervous system (CNS), cardiovascular, musculocutaneous, renal, and respiratory systems, etc. SLE can occur alone or in association with other autoimmune diseases, especially antiphospholipid syndrome (APS).
Ehsan Adib, Narges Gorbanmaleki, Amirreza Eterafi, Sara Jalali Jivan   +3 more
wiley   +1 more source