Results 131 to 140 of about 429,758 (251)

Acute Neurological Events in Children With Hemoglobin SC Disease: A Multicenter Retrospective Study

Pediatric Blood &Cancer, Volume 73, Issue 11, November 2026.
ABSTRACT Introduction Neurological manifestations in children with hemoglobin SC (HbSC) disease remain insufficiently characterized, particularly regarding acute events. The aim of this study was to describe the spectrum and frequency of acute neurological events in a multicenter cohort of children with HbSC disease.
Célia Paulmin, Bérengère Koehl, Audrey Maudoux, Hanine Mansour, Marie‐Hélène Odievre, Nathalie Garrec, Emilie Georget, Cécile Arnaud, Slimane Allali, Lydia Doumdo, Marie Belloy, Corinne Guitton   +11 more
wiley   +1 more source

Diagnostic patterns of haemoglobinopathies: A prospective observational study using high-performance liquid chromatography in a remote tertiary care center of Telangana.

Student's Journal of Health Research Africa
Background Haemoglobinopathies, including sickle cell disorders and thalassemias, are significant genetic conditions that alter hemoglobin structure and function.
Dr. Sumayya , Dr . Charitha Sravanthi Battu, Dr . K Raja Kumar   +2 more
doaj   +1 more source

Current advances in 2025: A critical review of selected topics by the Association for the Advancement of Blood and Biotherapies (AABB) Clinical Transfusion Medicine Committee

Transfusion, EarlyView.
Nabiha H. Saifee, Jennifer Andrews, Mary Berg, Stella T. Chou, Mischa Covington, Elizabeth P. Crowe, Ruchika Goel, Juliana A. Guarente, Tina Ipe, Jeremy W. Jacobs, Jessica Jacobson, Cyril Jacquot, Jenna Khan, Thane A. Kubik, Theodros Mamo, Michael F. Murphy, Kerry O'Brien, Monica B. Pagano, Anil K. Panigrahi, Jacqueline N. Poston, Scott E. Potter, Simon J. Stanworth, Moritz Stolla, Alyssa Ziman, Ryan A. Metcalf   +24 more
wiley   +1 more source

Nasopharyngeal Carcinoma Mimicking Juvenile Nasopharyngeal Angiofibroma in an Adolescent Ghanaian Male: A Diagnostic Pitfall

Clinical Case Reports, Volume 14, Issue 11, November 2026.
ABSTRACT Nasopharyngeal carcinoma can mimic juvenile nasopharyngeal angiofibroma in adolescent males on both demographics and imaging; bilateral cavernous sinus involvement and sensorineural hearing loss are atypical for juvenile nasopharyngeal angiofibroma (JNA) and should prompt expedited tissue diagnosis even in settings where biopsy of a presumed ...
Dennis Brempong, Margaret Neizer, Samuel Romeo Hammond, Benedict Takyi   +3 more
wiley   +1 more source

Dental considerations in the management of children suffering from sickle cell disease: A case report

Journal of Indian Society of Pedodontics and Preventive Dentistry, 2007
Sickle cell disease (SCD) is a genetically derived disorder characterized by the presence of an abnormal hemoglobin molecule, designated as hemoglobin S (HbS).
Ramakrishna Y
doaj  

Probing the Twisted Structure of Sickle Hemoglobin Fibers via Particle Simulations.

Biophysical Journal, 2016
Lu Lu, Xue-Jin Li, P. Vekilov, G. Karniadakis   +3 more
semanticscholar   +1 more source

SURMOUNT‐REAL UK: A Pragmatic Randomized Clinical Trial to Assess the Effectiveness of Tirzepatide in Adults With Obesity

Obesity, Volume 34, Issue 11, Page 2051-2060, November 2026.
ABSTRACT Objective SURMOUNT‐REAL UK will evaluate the effectiveness of tirzepatide when offered in addition to standard‐of‐care (SoC) in adults with Class I obesity (BMI ≥ 30 and ≤ 34.9 kg/m2) and without diabetes in a UK primary care setting. Methods A 5‐year, phase 4, multicenter, open‐label, pragmatic randomized clinical trial is enabled through ...
Martin K. Rutter, Julie Mount, J. Martin Gibson, Joanne Webb, Cheryl Marler, Catherine Reed, Mugdha Gore, Wenyu Ye, Elisa Gomez Valderas, John Wilding, Naveed Sattar, Melanie J. Davies, Kamlesh Khunti, Richard Haynes, Rachel L. Batterham   +14 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Targeting protein–protein interactions with reversible covalent modalities: Non‐cysteine chemistries

British Journal of Pharmacology, Volume 183, Issue 22, Page 6607-6626, November 2026.
Abstract Protein–protein interactions (PPIs) are central to diverse cellular functions, and represent a rapidly expanding class of therapeutic targets. Advancements in covalent drug design have enabled small‐molecule drugs to overcome challenges associated with engaging these targets, such as limited durations of action and difficult‐to‐drug (expansive,
Ruchira Basu, Steven Fletcher
wiley   +1 more source

Molecular insights into the irreversible mechanical behavior of sickle hemoglobin. [PDF]

J Biomol Struct Dyn, 2019
Yesudasan S, Douglas SA, Platt MO, Wang X, Averett RD.   +4 more
europepmc   +1 more source