Results 111 to 120 of about 429,758 (251)

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source

Sequential gastric and ileal perforations, a rare presentation in a man with sickle cell anemia: A case report

Journal of International Medical Research
The inheritance of the sickle gene (hemoglobin S) and another abnormal hemoglobin gene is described as sickle cell disease, and the homozygous form of the disease is hemoglobin SS.
John A Ashindoitiang, Victor IC Nwagbara, Dino N Magam, Victor D Nnalue, Maurice E Asuquo   +4 more
doaj   +1 more source

Smartphone‐Based Teledentistry to Support Clinical Triage and Risk‐Informed Dental Care in Patients With Inherited Bleeding and Haemoglobin Disorders: A Cross‐Sectional Diagnostic Agreement Study

Haemophilia, EarlyView.
ABSTRACT Introduction Patients with inherited bleeding and haemoglobin disorders face barriers to accessing timely dental care, increasing the risk of untreated oral disease and complications related to invasive procedures. Aim To evaluate the agreement between smartphone‐based asynchronous teledentistry and face‐to‐face examination for oral conditions,
Victor Cordeiro da Silva, Carolina Mendes Frusca do Monte, Leandro Tavares da Silva, Gabriela Silva Almeida, Claudia Santos Lorenzato, José Vitor Nogara Borges de Menezes, Fabian Calixto Fraiz, Cassius Carvalho Torres‐Pereira   +7 more
wiley   +1 more source

Efficacy of a virtual reality headset in the management of severe pain during a vaso‐occlusive crisis: A single‐centre study in adults with sickle cell disease

British Journal of Haematology, EarlyView.
Geoffrey Cheminet, Anne Corbasson, Kinda Al Kudsee, Marie Charmettan, Carole Barthélémy, Walid Namaoui, Djamal Khimoud, Jean‐Benoît Arlet   +7 more
wiley   +1 more source

Blood Cell Counts and the Duffy Null Phenotype: Beyond Neutropenia

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT The absence of Duffy antigen expression on red blood cells, caused by a single nucleotide polymorphism in the DARC/ACKR1 gene, confers protection against malaria and is associated with lower absolute neutrophil counts (ANC) in some studied populations.
Elvira Deolinda R. P. Velloso, Andreza Oliveira dos Santos, Carla Luana Dinardo, Carolina Bonet Bub, Leandro Dinalli Santos, Mauren Fernanda Moller dos Santos, João Carlos de Campos Guerra, Denise dos Anjos Laurentis de Sousa Campos, Monica Juliana Vieira, Fábio Julio da Luz, Alfredo Mendrone‐Junior, Rosana M. Cosentino Penteado   +11 more
wiley   +1 more source

Characterizing Red Blood Cell Rheological Parameters Using Automated Syllectometry: Conventional and Exploratory Multivariate Analyses

International Journal of Laboratory Hematology, EarlyView.
ABSTRACT Introduction Red blood cell (RBC) biomechanics are key determinants of blood rheology, microcirculatory flow, and tissue oxygen delivery, yet remain underutilized in clinical practice because of methodological variability and limited standardization.
Baran Dastaran, Yousra Tera, Maica Jhiezl Yunon, Maha Othman   +3 more
wiley   +1 more source

The Sickling Phenomenon and Heterogeneity of Deer Hemoglobin.

Experimental Biology and Medicine, 1964
SummaryA marked degree of heterogeneity is demonstrable in deer hemoglobin. This heterogeneity appears to be on a genetic basis. A single hemoglobin component responsible for sickling of deer hemoglobin can be identified.Addendum. Since this paper was prepared, similar electrophoretic results were reported by Kitchen, H., Putnam, F. W. and Taylor, W. J.
openaire   +2 more sources

Established and experimental treatments for sickle cell disease

Haematologica, 2004
Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin (HbS), which has the unique property of polymerizing when deoxygenated. The sickling process is markedly accelerated when intracellular concentration of HbS is increased. Due
L De Franceschi, R Corrocher
doaj  

Erythrocyte ‘Feierzeit’ reaction: Novel filamentous and vesicular response to n‐butyl acetate

Journal of Microscopy, EarlyView.
Abstract Human erythrocytes (red blood cells; RBCs) undergo spontaneous disassembly after several hours of exposure to n‐butyl acetate (nBA). Images of the morphological changes were captured in time‐lapse sequences using differential interference contrast (DIC) light microscopy.
Philip W. Kuchel
wiley   +1 more source

Racial disparities in anaemia associated with paediatric chronic kidney disease

British Journal of Haematology, EarlyView.
Manya Raina, Shay Tanna, Brandon H. Lee, Bradley A. Warady   +3 more
wiley   +1 more source