Results 91 to 100 of about 429,758 (251)

Carrying a crisis: The risk of a painful sickle cell crisis during pregnancy

British Journal of Haematology, EarlyView.
Commentary on: Auger et al. Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes. Br J Haematol 2026 (Online ahead of print). doi: 10.1111/bjh.70837.
Bart J. Biemond
wiley   +1 more source

Pathophysiology of Sickle Cell Disease

Annual Review of Pathology, 2018
Since the discovery of sickle cell disease (SCD) in 1910, enormous strides have been made in the elucidation of the pathogenesis of its protean complications, which has inspired recent advances in targeted molecular therapies. In SCD, a single amino acid
P. Sundd, M. Gladwin, Enrico M. Novelli
semanticscholar   +1 more source

Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes

British Journal of Haematology, EarlyView.
Summary We assessed the pregnancy outcomes of patients with sickle cell crises. We carried out a retrospective study of 2 698 556 pregnancies in Quebec, Canada between 1989 and 2022. The primary exposure was sickle cell anaemia with crisis during or outside of pregnancy. Outcomes included severe maternal morbidity and other pregnancy complications.
Nathalie Auger, Émilia Mailhot‐Diaferia, Gabriel Côté‐Corriveau, Gilles Paradis, Antoine Lewin, Aimina Ayoub, Anne‐Marie Parrot, Ashley Park, Brian Potter   +8 more
wiley   +1 more source

Spot Test for Detection of Sickling Hemoglobin

Clinical Chemistry, 1972
Abstract We designed a simple spot-plate method for detecting sickling hemoglobins and distinguishing hemoglobin SS from AS in samples of dried blood on filter paper. The test depends on the differential solubility of sickling hemoglobins in phosphate solutions with and without 3 molar urea.
S, Kelly, L, Desjardins
openaire   +2 more sources

An “acquired” hemoglobin J variant in a sickle cell disease patient

Therapeutics and Clinical Risk Management, 2008
Nawwar Swedan1, Kathleen Nicol2, Phylis Moder2, Samir Kahwash21Fellow in Transfusion Medicine, Ohio State University, Columbus, Ohio; 2Department of Laboratory Medicine, Nationwide Children’s Hospital, Columbus, OhioAbstract: We report the case
Nawwar Swedan, Kathleen Nicol, Phylis Moder, Samir Kahwash   +3 more
doaj  

Nitrite decreases sickle hemoglobin polymerization in vitro independently of methemoglobin formation. [PDF]

Toxicol Appl Pharmacol, 2023
Almeida LEF, Smith ML, Kamimura S, Vogel S, de Souza Batista CM, Quezado ZMN.   +5 more
europepmc   +1 more source

Phase 3, randomised, placebo‐controlled trial of voxelotor for the resolution of leg ulcers in sickle cell disease: RESOLVE

British Journal of Haematology, EarlyView.
In this trial, conducted in Kenya, Nigeria and Brazil, the resolution of leg ulcers was similar between the voxelotor and placebo arms. In the 12‐week blinded period, the number of sickle cell anaemia with crisis events was higher in the voxelotor arm compared to placebo.
Bernhards Ogutu, Janet Oyieko, Halima Bello‐Manga, Adeseye Akinsete, Jessie Githanga, José Valber Lima Meneses, Carolyn Hoppe, Mark W. Davis, Jeremy Rupon, Ching‐Ray Yu, Roberto Pinto, Elena Tudone, Ibrahim Musa Idris, Martin Meremikwu, Aderson da Silva Araújo, Rodolfo D. Cançado, Guilherme Fonseca, Patrícia Santos Resende Cardoso, Obiageli Eunice Nnodu, on behalf of the RESOLVE Investigators   +19 more
wiley   +1 more source

Renal involvement due to pigment casts in a patient with sickle cell disease, not everything is focal and segmental glomerulosclerosis

Nefrología (English Edition)
Sickle cell disease, is a genetic disorder caused by a mutation in the HBB gene, affecting the β-globin and resulting in the formation of sickle hemoglobin.
Lina M. Garzón, Edgar H. Dominguez, Nancy Janeth Vargas, Luz M. Mejía   +3 more
doaj   +3 more sources

Voxelotor does not inhibit sickle hemoglobin fiber formation upon complete deoxygenation. [PDF]

Biophys J, 2023
Worth EH, Fugate MK, Ferrone FA.
europepmc   +1 more source

Association of enlarged perivascular space burden with silent cerebral infarcts in children with sickle cell disease

British Journal of Haematology, EarlyView.
Enlarged perivascular spaces (ePVS) in the basal ganglia and centrum semiovale are highly prevalent in children with sickle cell disease (SCD). Enlarged PVS in the basal ganglia are associated with the presence of silent cerebral infarcts, another marker of neurological disease, in children with SCD. Summary Children with sickle cell disease (SCD) have
Kristine A. Karkoska, Jahnavi Gollamudi, Brady J. Williamson, Russell P. Sawyer, Daniel Woo, Achala Vagal, Hyacinth I. Hyacinth   +6 more
wiley   +1 more source