Results 81 to 90 of about 204,284 (265)

Hemoglobinas variantes em doadores de sangue do Centro de Hematologia e Hemoterapia do estado do Piauí (Hemopi): conhecendo o perfil epidemiológico para construir a rede de assistência Hemoglobin S variants in blood donors of the Hematology and Hemotherapy Center of the state of Piauí (Hemopi): understanding the epidemiological profile to create a support network

Revista Brasileira de Hematologia e Hemoterapia, 2009
The most highly prevalent inherited disease in Brazil and in the world, sickle cell anemia, is considered a public health problem. Characterized by homozygosis for the hemoglobin S gene, the individual has a range of signs and symptoms that require ...
Leonardo F. Soares, Evaldo H. Oliveira, Iraildo B. Lima, José M. Silva, Jônathas T. Mota, Claudia R. Bonini-Domingos   +5 more
doaj   +1 more source

Hemoglobin sickle cell disease in Brazil

Haematologica, 2012
We read with great interest the recent paper presented by Lionnet et al .[1][1] and we would like to briefly report our experience with hemoglobin SC (HbSC) disease. Before the institution of neonatal screening in Brazil, HbSC disease was considered a rare manifestation.[2][2] After 2001, however,
Ana Carolina Cabañas-Pedro, Josefina A. P. Braga, Roberta F Camilo-Araújo, Ana I. M. Silva, Perla Vicari, Maria Figueiredo   +5 more
openaire   +3 more sources

Sickle Cell Amenia in association with α-thalassemia-2 : biosynthetic and hematological studies [PDF]

, 1978
Patients with Sickle Cell Anemia (SS) associated with homozygous α-thalassemia-2 (-α/-α; βs/βs) are difficult to detect because the in vitro synthesis of hemoglobin chains may be balanced after prolonged incubation (>120 min).
Huisman, Titus Hendrik Jan, Directors of Sickle Cell Centers Meeting, Felice, Alex   +2 more
core  

Parvovirus B19 infections in paediatric sickle cell disease patients: Genotype and hydroxyurea treatment influence disease severity

British Journal of Haematology, EarlyView.
Summary In patients with sickle cell disease (SCD), parvovirus B19 infection (B19V) leads to acute anaemia (aplastic crisis), but may also be associated with other serious complications. We retrospectively analysed clinical data from paediatric SCD patients with B19V infections between 2023 and 2025, including symptoms, laboratory parameters ...
Matthias Bleeke, Arne Simon, Beate Winkler, Sabine Heine, Anna Eichinger, Ulrich von Both, Meinolf Siepermann, Sonya El Amouri, Arndt Borkhardt, Yvonne Pritschow, Wolfgang Novak, Michael Dworzak, Sarah Goretzki, Clara Held, Karin Beutel, Franziska Gams, Henriette Rudolph, Leila Koscher, Piet E. Beusker, Eckard Hamelmann, Stefan Weichert, Svenja Häuser, Maximilian Mauritz, Malik Aydin, Verena Wiegering, Regine Grosse, Rainer Misgeld, Martina Stiefel, Nicole Töpfner, Uta Falke, Lara Imhof, Laura Tagliaferri, Daniel Ebrahimi‐Fakhari, Andreas Groll, Marion Appel, Nora Naumann‐Bartsch, Michaela Nathrath, Olaf Beck, Solvej Heidtmann, Philipp Tischer, Ulf Schulze‐Sturm, Urs Mücke, Holger Cario   +42 more
wiley   +1 more source

Genetic variants and cell-free hemoglobin processing in sickle cell nephropathy

Haematologica, 2015
Intravascular hemolysis and hemoglobinuria are associated with sickle cell nephropathy. ApoL1 is involved in cell-free hemoglobin scavenging through association with haptoglobin-related protein.
Santosh L. Saraf, Xu Zhang, Binal Shah, Tamir Kanias, Krishnamurthy P. Gudehithlu, Rick Kittles, Roberto F. Machado, Jose A.L. Arruda, Mark T. Gladwin, Ashok K. Singh, Victor R. Gordeuk   +10 more
doaj   +1 more source

Carrying a crisis: The risk of a painful sickle cell crisis during pregnancy

British Journal of Haematology, EarlyView.
Commentary on: Auger et al. Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes. Br J Haematol 2026 (Online ahead of print). doi: 10.1111/bjh.70837.
Bart J. Biemond
wiley   +1 more source

Spot Test for Detection of Sickling Hemoglobin

Clinical Chemistry, 1972
Abstract We designed a simple spot-plate method for detecting sickling hemoglobins and distinguishing hemoglobin SS from AS in samples of dried blood on filter paper. The test depends on the differential solubility of sickling hemoglobins in phosphate solutions with and without 3 molar urea.
S, Kelly, L, Desjardins
openaire   +2 more sources

Sickle cell anaemia with and without crises: An observational study of pregnancy outcomes

British Journal of Haematology, EarlyView.
Summary We assessed the pregnancy outcomes of patients with sickle cell crises. We carried out a retrospective study of 2 698 556 pregnancies in Quebec, Canada between 1989 and 2022. The primary exposure was sickle cell anaemia with crisis during or outside of pregnancy. Outcomes included severe maternal morbidity and other pregnancy complications.
Nathalie Auger, Émilia Mailhot‐Diaferia, Gabriel Côté‐Corriveau, Gilles Paradis, Antoine Lewin, Aimina Ayoub, Anne‐Marie Parrot, Ashley Park, Brian Potter   +8 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Renal involvement due to pigment casts in a patient with sickle cell disease, not everything is focal and segmental glomerulosclerosis

Nefrología (English Edition)
Sickle cell disease, is a genetic disorder caused by a mutation in the HBB gene, affecting the β-globin and resulting in the formation of sickle hemoglobin.
Lina M. Garzón, Edgar H. Dominguez, Nancy Janeth Vargas, Luz M. Mejía   +3 more
doaj   +3 more sources