Results 101 to 110 of about 429,758 (251)

Determining of the Hydroxyurea Effluence on TCD Parameters of Sickle Cell Patients

مجله دانشکده پزشکی اصفهان, 2009
Background: Sickle cell disease is the most common hemoglobinopathies that affect a specific intracellular protein named as hemoglobin. This disease has several clinical manifestations including, CNS involvement.
Nasser Sharafadinzadeh, Nastaran Majdinasb, Khodamorad Zandian, Keiwan Taherpoor, Armaghan Moravej Aleali, Mohamad Pipelzadeh   +5 more
doaj  

Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling. [PDF]

Nat Commun, 2023
De Souza DC, Hebert N, Esrick EB, Ciuculescu MF, Archer NM, Armant M, Audureau É, Brendel C, Di Caprio G, Galactéros F, Liu D, McCabe A, Morris E, Schonbrun E, Williams D, Wood DK, Williams DA, Bartolucci P, Higgins JM.   +18 more
europepmc   +1 more source

Safety of Lowering the Platelet Transfusion Threshold Before Central Venous Catheterisation in Patients With Haematological Diseases

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Central venous catheter (CVC) insertion is frequently required in patients with haematological diseases. Despite limited evidence, thrombocytopenia often prompts prophylactic platelet transfusion before catheterisation. Methods We conducted an observational before‐and‐after study including the first non‐tunnelled CVC insertion ...
Mathias Lazarevic Lindblad, Elin Pålsson, Vladimir Lazarevic, Leila Naddi, Ola Borgquist, Lars Nilsson, Maria Adrian, Björn P. Bark, Thomas Kander   +8 more
wiley   +1 more source

Ocular Complications in Adults with Sickle Cell Disease in Lagos – A Comparative Study

Nigerian Journal of Medicine
Introduction: Sickle cell disease has been associated with ocular complications in several studies. However, it has not often been compared with nonhemoglobinopathy controls.
Kuburat Oliyide, Olubanke Theodora Ilo, Olufemi Emmanuel Babalola, Tunji Adenekan, Michael Olufemi Kehinde, Aribaba Olufisayo Tade, Folasade Akinsola   +6 more
doaj   +1 more source

ELEVATED MEAN CELL VOLUME IN SICKLE CELL ANAEMIA: ONE STORY, TOO MANY? [PDF]

Sanamed
Introduction: Sickle cell disease is a hereditary blood disorder characterized by defective hemoglobin. Red cell indices are proposed as potential tools for diagnosing and managing sickle cell disorders.
Jeremiah Zaccheaus, Alee Magnus
doaj   +1 more source

Fluorescence Lifetime Measurement of Prefibrillar Sickle Hemoglobin Oligomers as a Platform for Drug Discovery in Sickle Cell Disease. [PDF]

Biomacromolecules, 2022
Vunnam N, Hansen S, Williams DC, Been MO, Lo CH, Pandey AK, Paulson CN, Rohde JA, Thomas DD, Sachs JN, Wood DK.   +10 more
europepmc   +1 more source

HOPE Kids 2: Phase 3, Randomized Trial of Voxelotor in Children With SCD and Conditional Cerebral Blood Flow Velocities. [PDF]

Am J Hematol
ABSTRACT Children with SCD have elevated stroke risk, correlated with cerebral blood flow velocity (CBFV). HOPE Kids 2 was a phase 3, multicenter, double‐blind, placebo‐controlled trial evaluating the effect of voxelotor on CBFV. Participants aged 2 to < 15 years with SCD (HbSS/HbSβ0) and conditional CBFV (170 to < 200 cm/s) were randomized 1:1 to ...
Bello-Manga H, Abdullahi SU, Hassab H, Brown B, Nduba V, Githanga J, Akinsete AM, El-Beshlawy A, Hanna D, Segbefia C, Okpala I, Tantawy A, Ogutu B, Tubman VN, Paintsil V, Wali Y, Essa M, Telfer P, Dixon S, Hickman A, Doss JF, Davis MW, Rupon J, Kirkham FJ, Brown RC, HOPE Kids 2 Investigators.   +25 more
europepmc   +2 more sources

Genome Wide Association Study of Fetal Hemoglobin in Sickle Cell Anemia in Tanzania

PLoS ONE, 2014
Background Fetal hemoglobin (HbF) is an important modulator of sickle cell disease (SCD). HbF has previously been shown to be affected by variants at three loci on chromosomes 2, 6 and 11, but it is likely that additional loci remain to be discovered ...
S. N. Mtatiro, T. Singh, Helen Rooks, J. Mgaya, Harvest Mariki, D. Soka, B. Mmbando, Evarist B. Msaki, I. Kolder, S. Thein, S. Menzel, S. Cox, J. Makani, J. Barrett   +13 more
semanticscholar   +1 more source

Molecular dynamics simulations elucidate the misfolding mechanisms of secretion‐defective pancreatic lipase variants

The FEBS Journal, EarlyView.
Misfolding mutations in pancreatic lipase have been identified as potential contributors of chronic pancreatitis, an inflammatory disease of the human pancreas. Here, we describe the effect of these misfolding mutations on pancreatic lipase structure using molecular dynamics simulations and structural modeling.
Gyula Hoffka, András Szabó
wiley   +1 more source

MicroRNAs miR-451a and Let-7i-5p Profiles in Circulating Exosomes Vary among Individuals with Different Sickle Hemoglobin Genotypes and Malaria. [PDF]

J Clin Med, 2022
Oxendine Harp K, Bashi A, Botchway F, Dei-Adomakoh Y, Iqbal SA, Wilson MD, Adjei AA, Stiles JK, Driss A.   +8 more
europepmc   +1 more source